Product image of Iohexol Imax (Iohexol) supplied by GNH India

Iohexol Imax

Active Ingredient:
Iohexol
Origin:
EU

Iohexol Imax (Iohexol)

Iohexol, the active ingredient in Iohexol Imax, is an iodinated contrast media presented as a sterile solution for injection for intra‑arterial and intravenous use. It enhances X‑ray attenuation, allowing clearer visualization of vascular and tissue structures during computed tomography, angiography and other radiographic examinations in adult and pediatric patients.

GNH India supplies Iohexol Imax as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies, clinics and diagnostic imaging centres worldwide.

Manufacturer / TM Owner

Imax Diagnostic Imaging Limited

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Indications & Clinical Uses

Iohexol is used as an iodinated contrast agent to improve radiographic visualization in several diagnostic imaging procedures.

  • Computed Tomography (CT) imaging: provides enhanced contrast to delineate organs, vessels and lesions.
  • Angiography: improves visualization of arterial and venous structures during catheter‑based studies.
  • Conventional X‑ray examinations: supplies contrast for urography, arthrography and other radiographic studies requiring tissue differentiation.

How It Works

  • Iohexol contains a high density of iodine atoms that absorb X‑ray photons. After intravenous or intra‑arterial administration, the iodine distributes within the vascular and extracellular compartments, increasing the attenuation coefficient of blood and tissues. This creates a radiodense contrast between structures, enabling imaging systems to generate clearer, higher‑resolution images of anatomical detail.

Side Effects

Adverse reactions to Iohexol Imax may range from mild to severe and are reported in clinical practice.

Common Side Effects

  • Warmth or flushing: transient sensation during injection.
  • Nausea: mild gastrointestinal upset.
  • Metallic taste: brief alteration in oral sensation.

Serious or Rare Side Effects

  • Hypersensitivity reaction: urticaria, bronchospasm or anaphylaxis.
  • Renal impairment: contrast‑induced nephropathy, especially in patients with pre‑existing kidney disease.
  • Cardiovascular collapse: severe hypotension or arrhythmia.

Precautions & Warnings

When using Iohexol Imax, clinicians should observe several precautions to minimize risk and ensure optimal imaging outcomes.

  • Assess renal function: evaluate serum creatinine and eGFR before administration.
  • Review allergy history: identify prior reactions to iodinated contrast or related agents.
  • Hydration status: ensure adequate patient hydration to reduce nephrotoxicity.
  • Concomitant nephrotoxic drugs: avoid or adjust dosage of NSAIDs, aminoglycosides, or other renal‑impairing medications.
  • Pregnancy and lactation: use only if benefits outweigh potential risks, as safety data are limited.
  • Store at ambient temperature: keep in original container, protect from light and moisture, do not freeze.

Avoid Interactions

Iohexol Imax may interact with other agents, affecting safety or diagnostic quality.

Major Interactions (Avoid)

  • Metformin: risk of lactic acidosis in renal impairment; discontinue before and after contrast as per guidelines.
  • Iodine‑containing medications: may increase total iodine load, potentially affecting thyroid function.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate volume depletion and renal risk; monitor fluid status.
  • ACE inhibitors/ARBs: can potentiate contrast‑induced nephropathy; consider temporary suspension.
  • NSAIDs: increase risk of renal dysfunction; assess necessity.

Frequently Asked Questions

Iohexol Imax is an iodinated contrast medium used to enhance the visibility of vascular and tissue structures during diagnostic imaging procedures such as computed tomography (CT), angiography, and certain conventional X‑ray examinations. By increasing X‑ray attenuation, it helps radiologists obtain clearer images for accurate diagnosis.

Iohexol contains a high concentration of iodine atoms, which strongly absorb X‑ray photons. After injection, the iodine distributes within the bloodstream and extracellular space, raising the radiodensity of blood and tissues. This contrast difference allows imaging equipment to differentiate structures more distinctly, producing high‑resolution diagnostic images.

The dose of Iohexol Imax is determined by the prescribing clinician based on the specific imaging study, patient weight, age, and renal function. Dosage calculations follow established radiology guidelines and are individualized for each procedure; no fixed regimen can be stated without a medical order.

Safety data for Iohexol Imax during pregnancy and lactation are limited. It should be used only when the expected diagnostic benefit outweighs potential risks to the fetus or infant. Clinicians must evaluate each case carefully and discuss possible concerns with the patient.

To order Iohexol Imax, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Iohexol Imax is a non‑ionic, low‑osmolality iodinated contrast agent, offering a favorable safety profile compared with older high‑osmolality agents. Compared with other modern agents such as iopamidol or ioversol, Iohexol provides similar image quality while maintaining low rates of discomfort and adverse reactions, though specific choice may depend on institutional protocols and patient factors.

Iohexol Imax should be stored at ambient temperature, protected from light and moisture, and kept in its original packaging. The product must not be frozen or shaken vigorously. Follow the manufacturer’s label for any additional handling instructions to preserve sterility and efficacy.

Iohexol Imax is administered as a sterile solution for injection by qualified healthcare professionals. It is delivered intravenously or intra‑arterially, typically through a power injector or manual bolus, depending on the imaging protocol. Administration is performed in a controlled clinical setting with appropriate monitoring.

The most serious risks include severe hypersensitivity reactions such as anaphylaxis, contrast‑induced nephropathy leading to acute renal impairment, and cardiovascular events like hypotension or arrhythmia. Prompt recognition and management of these reactions are essential, and patients at higher risk should be closely monitored.

Iohexol Imax should be avoided in patients with a known severe allergy to iodinated contrast media, uncontrolled hyperthyroidism, or severe renal insufficiency (e.g., eGFR <30 mL/min/1.73 m²) unless the diagnostic benefit justifies the risk. Clinicians must assess individual contraindications before administration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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