Product image of Iohexol Zentiva (Iohexol) supplied by GNH India

Iohexol Zentiva

Active Ingredient:
Iohexol
Origin:
EU

Iohexol Zentiva (Iohexol)

Iohexol, the active ingredient in Iohexol Zentiva, is a non‑ionic iodinated contrast agent presented as a sterile solution for intraarterial, intrathecal, intravenous use. It provides radiographic contrast that enhances visualization of vascular and tissue structures during diagnostic imaging procedures.

GNH India supplies Iohexol Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Zentiva Pharma Uk Limited

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Indications & Clinical Uses

Iohexol Zentiva is used as a contrast medium in several radiologic examinations, improving image quality by increasing X‑ray attenuation.

  • Angiography: enhances visualization of blood vessels and vascular anomalies.
  • Computed Tomography (CT) scanning: improves differentiation of soft‑tissue structures and lesions.
  • Myelography: provides clear contrast within the spinal canal for nerve root assessment.
  • Urography: delineates the urinary tract and renal collecting system.

How It Works

  • Iohexol contains multiple iodine atoms that strongly absorb X‑ray photons. When administered, the iodine atoms increase the attenuation of X‑rays passing through blood vessels and tissues, creating a temporary contrast difference that allows detailed radiographic imaging of anatomical structures during procedures such as angiography, CT, and myelography.

Side Effects

Adverse reactions to Iohexol Zentiva can range from mild to severe and are reported in clinical practice.

Common Side Effects

  • Warm sensation or flushing at the injection site.
  • Nausea or vomiting.
  • Headache.
  • Metallic taste in the mouth.

Serious or Rare Side Effects

  • Allergic reactions, including anaphylaxis.
  • Seizures or neurological disturbances.
  • Acute renal impairment, especially in patients with pre‑existing kidney disease.

Precautions & Warnings

When using Iohexol Zentiva, clinicians should observe several safety measures.

  • Assess renal function: evaluate serum creatinine and eGFR before administration.
  • Check for iodine or contrast media allergy: obtain a thorough allergy history.
  • Ensure adequate hydration: promote renal clearance of the agent.
  • Avoid in patients with severe hyperthyroidism: iodine load may exacerbate the condition.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Iohexol Zentiva may interact with other drugs, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent use of other iodinated contrast agents: increases total iodine load.
  • High‑dose iodinated medications (e.g., amiodarone): may potentiate thyroid effects.
  • Nephrotoxic agents such as aminoglycosides: heighten risk of renal injury.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect fluid balance and renal clearance.
  • Metformin: risk of lactic acidosis if renal function declines.
  • ACE inhibitors or ARBs: monitor blood pressure and renal parameters.

Frequently Asked Questions

Iohexol Zentiva is a non‑ionic iodinated contrast medium used to improve image quality in diagnostic radiology procedures such as angiography, computed tomography (CT) scans, myelography, and urography. By increasing X‑ray attenuation, it helps clinicians visualize blood vessels, soft tissues, and organ systems more clearly during imaging.

Iohexol contains multiple iodine atoms that strongly absorb X‑ray photons. When injected into the bloodstream or administered intrathecally, the iodine increases the attenuation of X‑rays passing through the targeted area, creating a temporary contrast difference that enhances the radiographic image of vascular and tissue structures.

The dose of Iohexol Zentiva is determined by the prescribing physician based on the specific imaging procedure, patient weight, renal function, and the required level of contrast. Healthcare professionals calculate the appropriate volume and concentration to achieve optimal imaging while minimizing risk.

The safety of Iohexol Zentiva in pregnancy or while breastfeeding has not been definitively established. It should only be used if the potential diagnostic benefit outweighs any possible risk to the fetus or infant, and the decision should be made by the treating physician in consultation with the patient.

To order Iohexol Zentiva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and assist with import documentation.

Iohexol Zentiva is a non‑ionic, low‑osmolality iodinated contrast medium, offering a lower incidence of adverse reactions compared with older, high‑osmolality ionic agents. Its safety profile, image quality, and versatility across intra‑arterial, intravenous, and intrathecal routes make it a preferred choice for many diagnostic imaging applications.

Iohexol Zentiva should be stored at ambient temperature, preferably below 25 °C, in its original sealed container. Protect the solution from direct sunlight, moisture, and extreme temperature fluctuations. Do not freeze the product, and inspect the vial for particulate matter before use.

Iohexol Zentiva is administered by a qualified healthcare professional via intra‑arterial, intravenous, or intrathecal injection, depending on the imaging study. The injection is typically performed using a sterile technique, and the volume is adjusted to the specific diagnostic requirement and patient characteristics.

The most serious risks include severe allergic reactions such as anaphylaxis, acute renal impairment especially in patients with pre‑existing kidney disease, and rare neurological events like seizures. Prompt recognition and management of these reactions are essential, and patients should be monitored closely during and after administration.

Iohexol Zentiva should be avoided in patients with a known allergy to iodine or iodinated contrast media, those with severe uncontrolled hyperthyroidism, and individuals with markedly impaired renal function where the risk of contrast‑induced nephropathy outweighs diagnostic benefit. Clinical judgment is required for each case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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