Product image of Ionolyte (Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Sodium Acetate Trihydrate) supplied by GNH India

Ionolyte

Active Ingredient:
Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Sodium Acetate Trihydrate
Origin:
EU

Ionolyte (Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Sodium Acetate Trihydrate)

Magnesium chloride hexahydrate, potassium chloride, sodium chloride and sodium acetate trihydrate, the active ingredients in Ionolyte, is an IV electrolyte solution presented as an unspecified strength intravenous solution for intravenous use. It restores electrolyte balance and supports fluid homeostasis in patients with electrolyte depletion or requiring fluid resuscitation.
GNH India supplies Ionolyte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Romania Srl

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Indications & Clinical Uses

Ionolyte is used to correct electrolyte disturbances and support intravascular volume in clinical settings.

  • Electrolyte depletion: restores magnesium, potassium, sodium and acetate concentrations to normal levels.
  • Fluid resuscitation: provides essential ions that contribute to effective plasma volume expansion.
  • Perioperative electrolyte management: maintains electrolyte homeostasis during surgery and other invasive procedures.

How It Works

  • Ionolyte delivers magnesium, potassium, sodium and acetate ions directly into the extracellular fluid via intravenous infusion. These ions are rapidly distributed, correcting deficits, supporting cellular ion gradients, and participating in enzymatic processes that maintain fluid balance, nerve conduction and muscle contractility.

Side Effects

Ionolyte may be associated with adverse reactions that vary in frequency and severity.

Common Side Effects

  • Infusion site irritation or pain
  • Mild hypermagnesemia (elevated magnesium)
  • Mild hyperkalemia (elevated potassium)
  • Mild hypernatremia (elevated sodium)
  • Transient hypotension during rapid infusion
  • Nausea or mild gastrointestinal discomfort

Serious or Rare Side Effects

  • Severe hypermagnesemia leading to respiratory depression
  • Severe hyperkalemia causing cardiac arrhythmia
  • Cardiac arrest or severe arrhythmias
  • Anaphylactic or severe hypersensitivity reactions
  • Fluid overload with pulmonary edema
  • Metabolic acidosis from acetate accumulation

Precautions & Warnings

Ionolyte should be administered with careful clinical monitoring.

  • Baseline electrolytes: assess serum magnesium, potassium and sodium before infusion.
  • Cardiac monitoring: observe rhythm especially in patients with cardiac disease.
  • Renal function: adjust rate or volume in renal impairment to avoid accumulation.
  • Contraindications: avoid in known hypermagnesemia, hyperkalemia or severe fluid overload.
  • Caution in heart failure: monitor for signs of volume excess.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Ionolyte can interact with other medicines that affect electrolyte balance or cardiac function.

Major Interactions (Avoid)

  • Neuromuscular blocking agents: potentiation of muscle relaxation.
  • Loop diuretics: increased risk of rapid electrolyte shifts.
  • ACE inhibitors or ARBs: heightened risk of hyperkalemia.

Moderate Interactions (Monitor Closely)

  • Digoxin: altered potassium levels may affect drug toxicity.
  • NSAIDs: may impair renal clearance of electrolytes.
  • Beta‑blockers: potential additive effects on potassium homeostasis.

Frequently Asked Questions

Ionolyte is an intravenous electrolyte solution used to correct electrolyte depletion and support fluid resuscitation in patients who need rapid restoration of magnesium, potassium, sodium and acetate levels, such as those with dehydration, surgical blood loss, or critical illness.

The active ingredients—magnesium chloride hexahydrate, potassium chloride, sodium chloride and sodium acetate trihydrate—dissolve into their respective ions after infusion. These ions are taken up by the extracellular fluid, directly replenishing deficits, stabilising cell membranes, and contributing to acid‑base balance and vascular volume.

The dose of Ionolyte is determined by the prescribing clinician based on the patient’s electrolyte profile, fluid status and clinical condition. The healthcare professional selects the appropriate volume and infusion rate to achieve the desired correction.

Safety data for Ionolyte in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Ionolyte, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ionolyte provides a balanced combination of magnesium, potassium, sodium and acetate, whereas many standard saline solutions contain only sodium and chloride. This broader ion profile can address multiple electrolyte deficits in a single infusion, potentially reducing the need for additional supplements.

Ionolyte should be stored at ambient temperature, kept in its original sealed container, protected from direct sunlight, and stored away from moisture. Do not freeze the solution, and inspect for particulate matter before use.

Ionolyte is administered intravenously. The solution is typically infused through a peripheral or central venous line, with the rate adjusted according to the patient’s electrolyte levels, renal function and clinical response, as directed by the prescriber.

Serious risks include severe hypermagnesemia or hyperkalemia, which can cause cardiac arrhythmias or respiratory depression, as well as fluid overload leading to pulmonary edema and rare anaphylactic reactions. Continuous monitoring is essential during infusion.

Ionolyte should be avoided in patients with known hypermagnesemia, hyperkalemia, severe fluid overload, or hypersensitivity to any of its components. Clinicians should also exercise caution in individuals with significant renal impairment or uncontrolled cardiac disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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