Product image of Ionoven (Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Sodium Acetate Trihydrate) supplied by GNH India

Ionoven

Active Ingredient:
Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Sodium Acetate Trihydrate
Origin:
EU

Ionoven (Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Sodium Acetate Trihydrate)

Magnesium Chloride Hexahydrate, the active ingredient in Ionoven, is an electrolyte solution presented as an intravenous solution for IV use. It provides magnesium, potassium, sodium, and acetate ions to replace lost electrolytes and support fluid balance in patients requiring intravenous therapy, such as those with dehydration, surgery, or critical illness.

GNH India supplies Ionoven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The product meets EU quality standards and is distributed under strict regulatory compliance.

Manufacturer / TM Owner

Fresenius Kabi France S.A.S.

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Indications & Clinical Uses

Ionoven is used in clinical situations that require rapid restoration of electrolyte balance and intravascular volume.

  • Electrolyte replacement: restores magnesium, potassium, sodium and acetate levels in patients with documented deficits.
  • Fluid resuscitation: contributes to intravascular volume expansion during acute dehydration or shock.
  • Correction of electrolyte imbalances: normalises serum concentrations in surgical, intensive‑care or renal‑impairment settings.

How It Works

  • Ionoven delivers magnesium, potassium, sodium and acetate ions directly into the bloodstream via intravenous infusion. The ions participate in cellular enzymatic reactions, maintain membrane potential, and regulate acid‑base balance, while the acetate is metabolised to bicarbonate, supporting fluid homeostasis and correcting electrolyte disturbances.

Side Effects

Ionoven may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Mild hypermagnesemia: transient elevation of serum magnesium.
  • Hyperkalemia: modest increase in serum potassium.
  • Infusion site irritation: redness or discomfort at the catheter site.
  • Mild hypotension: temporary drop in blood pressure.
  • Nausea or vomiting.
  • Headache.

Serious or Rare Side Effects

  • Severe hypermagnesemia: risk of cardiac conduction abnormalities.
  • Life‑threatening arrhythmias due to electrolyte excess.
  • Anaphylactic or severe allergic reaction.
  • Marked hypotension or shock.
  • Metabolic acidosis from acetate overload.
  • Severe electrolyte disturbances requiring immediate medical intervention.

Precautions & Warnings

When using Ionoven, clinicians should observe several safety measures.

  • Assess baseline electrolyte levels: verify serum magnesium, potassium and sodium before infusion.
  • Monitor cardiac rhythm: watch for arrhythmias during and after administration.
  • Adjust dosing in renal impairment: reduced clearance may require slower infusion or lower concentration.
  • Use caution in patients with heart block or severe cardiac disease.
  • Avoid rapid infusion: administer at recommended rate to prevent circulatory overload.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Ionoven can interact with other medications that affect electrolyte balance.

Major Interactions (Avoid)

  • Concurrent IV potassium chloride solutions: risk of severe hyperkalemia.
  • Calcium gluconate or calcium chloride: may precipitate with magnesium.
  • Magnesium sulfate infusions: additive hypermagnesemia.
  • Loop diuretics administered simultaneously: can cause abrupt shifts in electrolytes.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: monitor renal function and potassium levels.
  • NSAIDs: may impair renal excretion of electrolytes.
  • Digoxin: potassium fluctuations can alter drug toxicity.
  • Antacids containing magnesium or aluminum: assess total magnesium load.
  • Thiazide diuretics: may potentiate electrolyte disturbances.

Frequently Asked Questions

Ionoven is an intravenous electrolyte solution used to replace magnesium, potassium, sodium and acetate ions in patients who have lost electrolytes due to dehydration, surgery, trauma, or critical illness, and to support fluid resuscitation.

Magnesium chloride hexahydrate dissociates in the bloodstream, providing magnesium ions that act as cofactors for many enzymatic reactions, help stabilise cardiac and neuromuscular function, and contribute to overall electrolyte balance alongside the other ions in the formulation.

The dose of Ionoven is determined by the prescribing clinician based on the patient’s electrolyte status, weight, renal function and clinical condition. The healthcare professional sets the infusion rate and total volume required for each individual case.

Safety data for Ionoven in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Ionoven, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Ionoven contains a balanced combination of magnesium, potassium, sodium and acetate, which differentiates it from solutions that provide only sodium chloride or potassium chloride. This broader ion profile can be advantageous when multiple electrolyte deficits need simultaneous correction.

Ionoven should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the container away from moisture, direct sunlight and extreme temperature fluctuations to maintain product stability.

Ionoven is administered intravenously. The solution is infused through a sterile IV line according to the rate and volume prescribed by the treating clinician, typically using an infusion pump or controlled drip set.

Serious risks include severe hypermagnesemia or hyperkalemia, which can lead to cardiac arrhythmias, profound hypotension, anaphylactic reactions, and metabolic acidosis. Continuous monitoring of electrolytes and cardiac status is essential during infusion.

Ionoven should be avoided in patients with known hypersensitivity to any component, severe renal failure where electrolyte clearance is markedly reduced, uncontrolled hypermagnesemia or hyperkalemia, and in those with severe cardiac conduction disorders unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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