Product image of Iopamiro (Iopamidol) supplied by GNH India

Iopamiro

Active Ingredient:
Iopamidol
Origin:
EU

Iopamiro (Iopamidol)

Iopamidol, the active ingredient in Iopamiro, is an iodinated contrast media presented as a solution for injection for intravenous use. It provides radiopaque contrast for imaging procedures such as CT scans, angiography, urography, myelography, and cardiac catheterization.

GNH India supplies Iopamiro as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bracco Imaging S.P.A.

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Indications & Clinical Uses

  • Iopamiro, an iodinated contrast agent, is used to enhance radiographic visualization in several imaging procedures.
  • CT scanning: improves delineation of vascular and organ structures during computed tomography.
  • Angiography: enhances visualization of blood vessels and arterial anatomy.
  • Urography: highlights the urinary tract for detailed imaging.
  • Myelography: provides contrast for spinal canal and nerve root assessment.
  • Cardiac catheterization: improves delineation of cardiac chambers and coronary arteries.

How It Works

  • Iopamidol is a non‑ionic, low‑osmolality iodinated compound that absorbs X‑ray photons, increasing attenuation of blood and tissues. This creates a radiopaque contrast between vascular or organ structures and surrounding tissues, allowing enhanced visualization during CT, angiography, urography, myelography, and cardiac catheterization procedures.

Side Effects

Iopamiro may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Warmth or flushing sensation during injection.
  • Metallic or salty taste in the mouth.
  • Mild nausea or vomiting.
  • Headache or dizziness.
  • Injection site discomfort or pain.
  • Transient hypotension.

Serious or Rare Side Effects

  • Severe allergic reactions, including anaphylaxis.
  • Contrast‑induced nephropathy leading to acute kidney injury.
  • Significant hypotension or cardiovascular collapse.
  • Seizures or neurological disturbances.
  • Cardiac arrhythmias.
  • Pulmonary edema.

Precautions & Warnings

  • Use of Iopamiro requires careful assessment and monitoring to minimize risks.
  • Assess renal function: evaluate serum creatinine and eGFR before administration.
  • Screen for iodine allergy: obtain detailed allergy history and consider pre‑medication if needed.
  • Use lowest effective dose: tailor volume to the specific imaging study.
  • Monitor vital signs: observe patients during and after injection for reactions.
  • Avoid in severe iodine hypersensitivity: contraindicated in patients with known severe reactions.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Iopamiro can interact with several medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Metformin: discontinue before and after contrast to prevent lactic acidosis.
  • Iodine‑containing radiopharmaceuticals: avoid concurrent use due to cumulative iodine load.
  • Thyroid hormone therapy: may affect thyroid function tests.

Moderate Interactions (Monitor Closely)

  • NSAIDs: monitor renal function as combined nephrotoxic potential increases risk.
  • Aminoglycoside antibiotics: watch for additive renal toxicity.
  • Diuretics: assess fluid and electrolyte status during contrast administration.

Frequently Asked Questions

Iopamiro is an iodinated contrast medium used to enhance the visibility of blood vessels, organs, and tissues during imaging procedures such as computed tomography (CT) scans, angiography, urography, myelography, and cardiac catheterization. The contrast improves diagnostic accuracy by creating a clear distinction between structures on X‑ray based images.

Iopamidol contains iodine atoms that strongly absorb X‑ray photons. When injected intravenously, it increases the attenuation of X‑rays in the blood and extracellular fluid, producing a radiopaque effect. This contrast between enhanced and non‑enhanced tissues allows clinicians to visualize anatomical details that would otherwise be indistinguishable on standard radiographs.

The dose of Iopamiro is individualized by the prescribing physician based on the specific imaging study, patient body weight, renal function, and the required level of contrast enhancement. Standard dosing guidelines exist, but the final amount administered is always determined by the radiologist or clinician performing the procedure.

Iopamiro is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy only if clearly needed. Limited data are available for breastfeeding; a decision should be made after weighing potential benefits against any possible risk to the infant.

To order Iopamiro, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Iopamiro (iopamidol) is a non‑ionic, low‑osmolality iodinated contrast medium, offering a favorable safety profile compared with older high‑osmolality agents. It provides comparable image quality while reducing the incidence of discomfort and adverse reactions. Compared with other low‑osmolality agents, its physicochemical properties are similar, and choice often depends on institutional preference and specific formulation availability.

Iopamiro should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from moisture and direct sunlight. Do not freeze the product. Before use, inspect the vial for particulate matter or discoloration and ensure the solution is at room temperature to avoid precipitation.

Iopamiro is administered as an intravenous injection or infusion by a qualified healthcare professional. The solution is typically delivered through a peripheral or central vein using a power injector or manual syringe, depending on the imaging protocol. Administration speed and volume are adjusted according to the specific diagnostic procedure.

The most serious risks include severe allergic reactions such as anaphylaxis, contrast‑induced nephropathy leading to acute kidney injury, significant hypotension or cardiovascular collapse, and rare neurological events like seizures. Patients with known iodine hypersensitivity, impaired renal function, or uncontrolled cardiovascular disease require careful assessment before use.

Iopamiro should be avoided in patients with a documented severe allergy to iodinated contrast media, those with uncontrolled asthma or severe bronchospasm, and individuals with markedly impaired renal function where alternative imaging is feasible. Caution is also advised for patients on metformin, as temporary discontinuation may be required to reduce the risk of lactic acidosis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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