Product image of Iopamiron (Iopamidol) supplied by GNH India

Iopamiron

Active Ingredient:
Iopamidol
Origin:
EU

Iopamiron (Iopamidol)

Iopamidol, the active ingredient in Iopamiron, is an iodinated contrast media presented as a sterile solution for injection for intra‑arterial, intra‑articular, and intrathecal administration. It provides radiodensity by absorbing X‑rays, thereby enhancing contrast between vascular or tissue structures during diagnostic imaging procedures in adult and pediatric patients.

GNH India supplies Iopamiron as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, diagnostic centres and clinics worldwide. The company adheres to stringent quality standards and regulatory compliance to guarantee product integrity through validated manufacturing and distribution processes.

Manufacturer / TM Owner

Bracco Imaging France

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Indications & Clinical Uses

Iopamiron is an iodinated contrast agent used in radiographic imaging procedures to improve visualization of vascular and tissue structures.

  • Angiography: enhances vessel delineation for accurate diagnosis.
  • Arthrography: improves joint space contrast to assess cartilage and ligaments.
  • Myelography: provides clear spinal canal imaging for nerve root evaluation.
  • Computed Tomography (CT) with contrast: increases lesion detection and organ delineation.
  • Other diagnostic imaging procedures requiring intravascular or intrathecal contrast: facilitates detailed anatomical assessment.

How It Works

  • Iopamidol is a non‑ionic, low‑osmolality iodinated contrast medium. After injection, its iodine atoms absorb X‑ray photons, increasing the radiodensity of blood vessels and extracellular spaces. The compound distributes rapidly in the extracellular fluid without binding to specific receptors, creating a temporary contrast between structures that enhances image quality during radiographic, CT, and fluoroscopic examinations.

Side Effects

Iopamiron may cause a range of adverse reactions following administration.

Common Side Effects

  • Warmth or flushing sensation at the injection site.
  • Metallic taste in the mouth.
  • Nausea or mild vomiting.
  • Headache or dizziness.
  • Mild injection‑site pain or bruising.
  • Transient hypertension.

Serious or Rare Side Effects

  • Severe allergic reactions, including anaphylaxis.
  • Acute renal impairment or failure.
  • Seizures or convulsions.
  • Hypotension or cardiovascular collapse.
  • Pulmonary edema or respiratory distress.
  • Cardiac arrest.

Precautions & Warnings

Prior to using Iopamiron, several safety considerations should be observed.

  • Renal function assessment: evaluate serum creatinine and eGFR before administration.
  • Allergy history: screen for prior reactions to iodinated contrast agents.
  • Use lowest effective dose: tailor volume to the specific imaging requirement.
  • Monitor vital signs: observe blood pressure, heart rate, and oxygen saturation during and after injection.
  • Contraindication in severe iodine allergy: avoid use in patients with documented hypersensitivity.
  • Store below 25°C: keep in original container, protect from light, and do not freeze.

Avoid Interactions

Iopamiron can interact with other medications, influencing safety and efficacy.

Major Interactions (Avoid)

  • Concurrent use of other iodinated contrast agents: increases cumulative iodine load.
  • High‑dose nephrotoxic drugs (e.g., aminoglycosides, amphotericin B): heightens risk of renal injury.
  • Metformin in patients with impaired renal function: risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may exacerbate volume depletion and affect renal clearance.
  • ACE inhibitors or ARBs: monitor renal function and blood pressure.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase potential for contrast‑induced nephropathy.

Frequently Asked Questions

Iopamiron is an iodinated contrast medium used to enhance the visibility of blood vessels, organs, and tissues during diagnostic imaging procedures such as angiography, arthrography, myelography, and computed tomography (CT) scans that require intravascular or intrathecal contrast.

Iopamidol contains iodine atoms that strongly absorb X‑ray photons. When injected, it temporarily increases the radiodensity of the extracellular space and vascular structures, creating a clear contrast between different tissues and allowing radiologists to obtain detailed images of anatomical areas.

The dose of Iopamiron is individualized by the prescribing physician based on the specific imaging study, patient weight, renal function, and the required level of contrast enhancement. Only a qualified healthcare professional should determine the appropriate amount.

The safety of Iopamiron in pregnancy and lactation has not been definitively established. It should be used only if the diagnostic benefit outweighs potential risks, and the decision should be made by the treating physician in consultation with the patient.

To order Iopamiron, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Iopamiron (iopamidol) is a non‑ionic, low‑osmolality contrast medium, which generally offers a lower incidence of adverse reactions compared with older high‑osmolality agents. Its safety profile and imaging efficacy are comparable to other modern non‑ionic agents such as iohexol and iopromide.

Iopamiron should be stored below 25 °C in its original packaging, protected from light and moisture. Do not freeze the solution, and avoid shaking the vial vigorously. Inspect the product for particulate matter before use.

Iopamiron is administered as a sterile solution for injection via intra‑arterial, intra‑articular, or intrathecal routes, depending on the imaging procedure. The injection is performed by a qualified healthcare professional under aseptic conditions, often using a power injector for controlled delivery.

Serious risks include severe allergic reactions (anaphylaxis), acute renal failure, hypotension or cardiovascular collapse, seizures, and, in rare cases, pulmonary edema or cardiac arrest. Immediate medical attention is required if any of these events occur.

Patients with a known hypersensitivity to iodinated contrast media, severe renal impairment, uncontrolled hyperthyroidism, or those who have experienced a previous severe reaction to any contrast agent should generally avoid Iopamiron, unless the benefits clearly outweigh the risks and appropriate precautions are taken.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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