Product image of Iopasen (Iopamidol) supplied by GNH India

Iopasen

Active Ingredient:
Iopamidol
Origin:
EU

Iopasen (Iopamidol)

Iopamidol, the active ingredient in Iopasen, is a non‑ionic iodinated contrast agent presented as a sterile solution for intravenous use. It provides contrast enhancement for imaging procedures such as angiography, computed tomography, urography and myelography, allowing clearer visualization of blood vessels and tissues.

GNH India supplies Iopasen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Industria Farmaceutica Galenica Senese S.R.L..

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Indications & Clinical Uses

Iopasen is a non‑ionic iodinated contrast agent used in diagnostic imaging procedures that require enhanced X‑ray attenuation.

  • Angiography: provides detailed vascular images to aid diagnosis and guide interventions.
  • Computed tomography (CT) imaging: improves organ and tissue contrast for accurate assessment.
  • Urography: enhances visualization of the urinary tract for detecting obstructions or lesions.
  • Myelography: offers clear spinal canal imaging to evaluate nerve root and disc pathology.

How It Works

  • Iopamidol acts as a non‑ionic iodinated contrast medium that contains iodine atoms with high atomic number, which increase X‑ray attenuation when administered intravenously. The agent distributes rapidly within the extracellular fluid, highlighting blood vessels and organ structures during imaging. Its low osmolality and non‑ionic nature reduce the risk of adverse reactions while providing consistent contrast enhancement for radiographic procedures.

Side Effects

Iopasen may cause a range of adverse reactions, from mild to severe, following intravenous administration.

Common Side Effects

  • Warmth or flushing sensation at the injection site
  • Metallic or bitter taste in the mouth
  • Nausea or vomiting
  • Mild headache
  • Transient urticaria or skin rash
  • Mild hypotension

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction
  • Acute kidney injury or renal impairment
  • Seizures or convulsions
  • Cardiac arrhythmias
  • Severe hypotension or shock
  • Pulmonary edema or respiratory distress

Precautions & Warnings

Prior to using Iopasen, clinicians should consider several safety measures to minimize risks.

  • Assess renal function: evaluate serum creatinine and eGFR before administration.
  • Review allergy history: identify prior reactions to iodinated contrast agents.
  • Use lowest effective dose: tailor volume to the specific imaging study.
  • Monitor vital signs: observe patients during and after injection for adverse reactions.
  • Avoid in patients with known hypersensitivity to iodine or contrast media.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Iopasen can interact with other medications, influencing safety and efficacy.

Major Interactions (Avoid)

  • Metformin: discontinue before and after contrast exposure to reduce risk of lactic acidosis.
  • Iodine‑containing drugs (e.g., amiodarone, potassium iodide): may increase iodine load and affect thyroid function.
  • Radioactive iodine therapy: can interfere with diagnostic imaging and thyroid uptake.

Moderate Interactions (Monitor Closely)

  • NSAIDs and other nephrotoxic agents: increase risk of renal impairment.
  • Diuretics: may exacerbate volume depletion and affect renal clearance.
  • Antihypertensives (e.g., ACE inhibitors): monitor blood pressure and renal function during and after administration.

Frequently Asked Questions

Iopasen is a sterile intravenous solution containing iopamidol, a non‑ionic iodinated contrast agent. It is used to enhance X‑ray based imaging studies such as angiography, computed tomography (CT), urography, and myelography, providing clearer visualization of blood vessels, organs, and tissues for diagnostic and interventional procedures.

Iopamidol works by delivering iodine atoms, which have a high atomic number, into the bloodstream. These atoms increase X‑ray attenuation, creating a contrast between blood‑filled structures and surrounding tissues. The resulting enhanced images allow clinicians to better assess vascular anatomy and organ morphology during radiographic examinations.

The dose of Iopasen is individualized and determined by the prescribing physician based on the specific imaging study, patient weight, renal function, and clinical requirements. Healthcare professionals calculate the appropriate volume and concentration to achieve optimal image quality while minimizing potential adverse effects.

The safety of Iopasen in pregnancy or while breastfeeding has not been definitively established. Use is generally reserved for situations where the diagnostic benefit outweighs potential risks. Clinicians should evaluate the necessity of the procedure and consider alternative imaging methods when possible.

To order Iopasen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Iopasen contains iopamidol, a low‑osmolality, non‑ionic iodinated contrast medium. Compared with older high‑osmolality agents, it typically offers a lower incidence of adverse reactions and better patient tolerance. Relative to other low‑osmolality agents, its safety profile and imaging efficacy are comparable, with selection often based on institutional preference, cost, and specific procedural requirements.

Iopasen should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from direct sunlight, moisture, and extreme temperature fluctuations. Do not freeze the solution, and ensure the container remains sealed until use to maintain sterility and stability.

Iopasen is administered intravenously by a qualified healthcare professional. The solution is injected through a peripheral or central vein, typically using a power injector or manual bolus, depending on the imaging protocol. Proper aseptic technique and appropriate injection rate are essential to achieve optimal contrast enhancement and reduce the risk of adverse events.

The most serious risks include severe allergic reactions such as anaphylaxis, acute kidney injury especially in patients with pre‑existing renal impairment, and cardiovascular events like hypotension or arrhythmias. Prompt recognition and management of these reactions are critical, and patients should be monitored closely during and after administration.

Iopasen should be avoided in individuals with a known hypersensitivity to iopamidol or other iodinated contrast media, those with severe renal dysfunction where alternative imaging is possible, and patients who have experienced prior severe reactions to contrast agents. Clinicians must assess each patient’s medical history before administration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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