Product image of Iopidine (Apraclonidine) supplied by GNH India

Iopidine

Active Ingredient:
Apraclonidine
Origin:
EU

Iopidine (Apraclonidine)

Apraclonidine, the active ingredient in Iopidine, is a alpha-2 adrenergic agonist presented as a 0.5% ophthalmic solution for ocular (topical) use. It treats elevated intra‑ocular pressure in conditions such as glaucoma and ocular hypertension, and is also used to manage post‑operative ocular inflammation.

GNH India supplies Iopidine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Essential Pharma Limited

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Indications & Clinical Uses

Iopidine (apraclonidine) is used in ocular conditions that involve elevated intra‑ocular pressure or postoperative inflammation.

  • Glaucoma: reduces intra‑ocular pressure to help prevent optic nerve damage.
  • Ocular hypertension: lowers intra‑ocular pressure in patients with elevated pressure but no optic nerve damage.
  • Post‑operative ocular inflammation: decreases intra‑ocular pressure and inflammation after eye surgery.

How It Works

  • Apraclonidine acts as a selective alpha‑2 adrenergic receptor agonist in the eye. Activation of these receptors reduces aqueous humor production by the ciliary body and enhances uveoscleral outflow, leading to a decrease in intra‑ocular pressure. The combined effect helps control pressure‑related ocular conditions.

Side Effects

Iopidine may cause ocular and systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Burning or stinging sensation: transient discomfort upon instillation.
  • Redness of the eye: mild conjunctival hyperemia.
  • Blurred vision: temporary visual disturbance.
  • Dry eye: reduced tear production.
  • Foreign body sensation: feeling of something in the eye.

Serious or Rare Side Effects

  • Allergic reaction: swelling, rash, or severe eye irritation.
  • Corneal edema: swelling of the cornea affecting vision.
  • Severe ocular inflammation: persistent redness, pain, or discharge.
  • Systemic hypotension: low blood pressure if absorbed in significant amounts.

Precautions & Warnings

Before using Iopidine, consider the following precautions to ensure safe and effective therapy.

  • Pregnancy: safety not established; avoid unless benefit outweighs risk.
  • Breastfeeding: unknown excretion; caution advised.
  • Pre‑existing ocular conditions: use with care in patients with severe dry eye or corneal disease.
  • Concomitant ocular medications: monitor for additive pressure‑lowering effects.
  • Systemic cardiovascular disease: watch for hypotension in susceptible individuals.
  • Store at room temperature: keep below 25 °C, protect from light and moisture, retain in original container.

Avoid Interactions

Iopidine can interact with other agents, influencing ocular pressure or systemic effects.

Major Interactions (Avoid)

  • Beta‑blocker eye drops: additive intra‑ocular pressure reduction may cause excessive lowering.
  • Systemic alpha‑2 agonists (e.g., clonidine): risk of enhanced hypotensive effect.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: may affect corneal healing.
  • Anticholinergic eye drops: potential for reduced efficacy.
  • Systemic antihypertensives: monitor blood pressure for additive hypotension.

Frequently Asked Questions

Iopidine is an ophthalmic solution containing apraclonidine that is prescribed to lower intra‑ocular pressure in glaucoma and ocular hypertension, and to help control pressure and inflammation after eye surgery.

Apraclonidine selectively stimulates alpha‑2 adrenergic receptors in the eye, which reduces the production of aqueous humor and increases uveoscleral outflow, resulting in a net decrease in intra‑ocular pressure.

The dosing regimen for Iopidine is determined by the prescribing clinician based on the individual patient's condition and response. The prescriber will specify the number of drops and frequency.

Safety of apraclonidine in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and under medical supervision.

To order Iopidine, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

The most common alternative is timolol, a beta‑blocker eye drop. While timolol reduces aqueous humor production via beta‑adrenergic blockade, Iopidine works through alpha‑2 agonism, offering a different mechanism that may be preferred in patients who cannot tolerate beta‑blockers or need additional pressure control.

Iopidine should be stored at room temperature, below 25 °C, in its original container. Protect the bottle from light and moisture, and keep the cap tightly closed to maintain sterility.

Iopidine is applied topically to the eye as directed by the prescriber, typically one drop in the affected eye(s) at the prescribed frequency. Patients should avoid touching the tip of the bottle to the eye or any surface.

Serious risks include severe allergic reactions, corneal edema, and systemic hypotension, especially in patients taking other hypotensive agents. Any sudden vision changes, intense eye pain, or systemic symptoms should prompt immediate medical evaluation.

Iopidine should be avoided in patients with known hypersensitivity to apraclonidine or any component of the formulation, and used with caution in those with severe dry eye, corneal disease, uncontrolled cardiovascular conditions, or during pregnancy and lactation unless clearly indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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