Iopidine (Apraclonidine)

Apraclonidine is a selective alpha‑2 adrenergic receptor agonist. By stimulating these receptors in the ciliary body, it decreases aqueous humor production and modestly increases uveoscleral outflow, resulting in lowered intra‑ocular pressure.

The dosing regimen for Iopidine is determined by the prescribing clinician based on the patient’s condition and response. Typically, one drop is instilled in the affected eye(s) once or twice daily, but exact frequency should follow the healthcare provider’s instructions.

Safety of apraclonidine during pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Iopidine product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with beta‑blocker eye drops, apraclonidine offers a different mechanism by reducing aqueous production via alpha‑2 receptor activation, which can be useful when patients are intolerant to beta‑blockers. It is generally used as adjunct therapy or when a rapid IOP reduction is needed.

Iopidine ophthalmic solution should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and discard any solution that appears discolored or cloudy.

Iopidine is applied topically to the eye. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place a single drop into the conjunctival sac of the affected eye(s). Avoid touching the tip of the bottle to the eye or any surface.

Serious adverse reactions, though rare, include severe allergic responses such as swelling, rash, or urticaria, and significant ocular inflammation like uveitis or keratitis. Systemic hypotension may also occur, especially in patients with pre‑existing low blood pressure or when combined with antihypertensive drugs.

Iopidine is contraindicated in individuals with known hypersensitivity to apraclonidine or any excipients in the formulation. Caution is advised for patients with cardiovascular disease, low blood pressure, or those taking systemic antihypertensive agents. Pregnant or nursing women should only use it if clearly indicated by a physician.