Iopidine (Apraclonidine)

Apraclonidine selectively stimulates alpha‑2 adrenergic receptors in the eye. This reduces the production of aqueous humor and increases uveoscleral outflow, resulting in a net decrease in intra‑ocular pressure. The dual action helps control pressure in glaucoma and related disorders.

The exact dosing regimen is determined by the prescribing ophthalmologist based on the patient’s condition and response. Typically, a single drop is instilled in the affected eye(s) as directed, and the prescriber may adjust frequency according to intra‑ocular pressure measurements.

Safety data for apraclonidine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Iopidine, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The most common alternative is timolol, a beta‑blocker that also lowers intra‑ocular pressure but through reduced aqueous humor production alone. Apraclonidine adds a modest increase in uveoscleral outflow and may be preferred when beta‑blockers are contraindicated or when additional pressure reduction is needed.

Store Iopidine at room temperature, below 25 °C. Keep the bottle in its original packaging, protect it from direct light and moisture, and ensure the cap is tightly closed to maintain sterility.

Iopidine is applied as an ophthalmic solution. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place one drop into the conjunctival sac of the prescribed eye(s). Close the eye gently and avoid blinking excessively for a few seconds.

Serious adverse events, although rare, include severe allergic reactions, corneal edema, marked eye pain, systemic hypotension, and cardiac arrhythmias. If any of these occur, the patient should discontinue use immediately and seek medical attention.

Iopidine should not be used by individuals with a known hypersensitivity to apraclonidine or any excipients in the formulation. Caution is also advised for patients with severe cardiovascular disease, uncontrolled hypertension, or those taking interacting systemic medications without medical supervision.