Iopidine (Apraclonidine)

Apraclonidine is a selective alpha‑2 adrenergic receptor agonist. Activation of these receptors in the ciliary body decreases aqueous humor production, while also enhancing uveoscleral outflow. The combined effect reduces intraocular pressure, which is beneficial in glaucoma and ocular hypertension.

The dosing regimen for Iopidine is determined by the prescribing ophthalmologist. Typically, one drop is instilled in the affected eye(s) once or twice daily, but the exact frequency and duration depend on the individual patient’s condition and response to therapy. Patients should follow the prescriber’s instructions precisely.

The safety of apraclonidine in pregnancy and lactation has not been established. It is classified as pregnancy category unknown, and use is generally reserved for situations where the potential benefit justifies any potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Iopidine. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Iopidine (apraclonidine) belongs to the alpha‑2 adrenergic agonist class, offering a dual mechanism of reduced aqueous production and increased outflow. Compared with beta‑blockers, it may be better tolerated in patients with respiratory disease, while brimonidine provides a similar mechanism but at a higher concentration. Choice depends on individual patient factors and physician preference.

Iopidine should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and avoid freezing. Do not use the solution if it appears discolored or if the expiration date has passed.

Iopidine is applied as a topical eye drop. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and instill one drop into the conjunctival sac of the affected eye(s). The eye should be gently closed for a minute to allow absorption, and any excess fluid can be dabbed away.

Although uncommon, serious adverse reactions can include severe allergic responses such as angioedema, marked hypotony (excessive drop in intraocular pressure), corneal edema, or uveitis. Systemic hypotension may occur if significant absorption happens, especially in patients using other antihypertensive agents. Patients should seek immediate medical attention if they experience sudden vision loss, severe eye pain, or signs of an allergic reaction.

Iopidine is contraindicated in individuals with known hypersensitivity to apraclonidine or any component of the formulation. Caution is advised for patients with narrow‑angle glaucoma, as rapid pressure changes may precipitate angle closure. It should also be avoided in patients taking systemic alpha‑2 agonists or antihypertensives without medical supervision.