Product image of Iopidine (Apraclonidine Hydrochloride) supplied by GNH India

Iopidine

Active Ingredient:
Apraclonidine Hydrochloride
Origin:
EU

Iopidine (Apraclonidine Hydrochloride)

Apraclonidine Hydrochloride, the active ingredient in Iopidine, is a alpha‑2 adrenergic agonist presented as a ophthalmic solution for ocular use. It lowers intraocular pressure in patients with ocular hypertension and various forms of glaucoma. By decreasing aqueous humor production and enhancing uveoscleral outflow, it helps preserve visual function and prevent optic nerve damage. The medication is indicated for reduction of intraocular pressure following ocular surgery and as adjunct therapy in open‑angle glaucoma. It is marketed in the European Union and meets stringent quality standards.

GNH India supplies Iopidine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Essential Pharma Limited

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Indications & Clinical Uses

Apraclonidine is used to manage conditions that involve elevated intraocular pressure, a key factor in glaucoma and postoperative ocular care.

  • Ocular hypertension: reduces intraocular pressure to prevent progression to glaucoma.
  • Open-angle glaucoma: lowers pressure as adjunctive therapy to control disease.
  • Post‑operative ocular pressure control: helps maintain target pressure after eye surgery.

How It Works

  • Apraclonidine hydrochloride selectively stimulates alpha‑2 adrenergic receptors in the ciliary body, leading to decreased production of aqueous humor. It also enhances uveoscleral outflow, contributing to a net reduction in intraocular pressure. The dual action helps maintain pressure within normal limits, thereby protecting the optic nerve from pressure‑related damage.

Side Effects

Apraclonidine may cause ocular and systemic adverse reactions, which are categorized by frequency.

Common Side Effects

  • Burning or stinging at the eye.
  • Conjunctival redness.
  • Transient blurred vision.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angioedema, anaphylaxis).
  • Persistent ocular inflammation.
  • Marked hypotension causing dizziness or fainting.

Precautions & Warnings

Use of Iopidine requires careful consideration of patient-specific factors and proper handling.

  • Contraindication: avoid in patients with known hypersensitivity to apraclonidine or any component of the formulation.
  • Caution: monitor patients with cardiovascular disease or low blood pressure.
  • Use: limit to prescribed dosing frequency; excessive use may increase risk of ocular irritation.
  • Pregnancy: safety not established; weigh potential benefits against unknown risks.
  • Driving: advise patients that transient visual disturbances may affect tasks requiring clear vision.
  • Store at room temperature below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Apraclonidine may interact with other ocular or systemic agents, affecting its safety and efficacy.

Major Interactions (Avoid)

  • Concurrent use with other ocular alpha‑agonists may cause additive hypotensive effect.
  • Systemic antihypertensive agents may potentiate blood pressure lowering.

Moderate Interactions (Monitor Closely)

  • Beta‑blocker eye drops may influence intraocular pressure control.
  • Topical anesthetics may increase ocular irritation when used together.
  • Non‑steroidal anti‑inflammatory eye drops could alter drug absorption.

Frequently Asked Questions

Iopidine contains apraclonidine hydrochloride and is prescribed to lower intraocular pressure in ocular hypertension, open‑angle glaucoma, and after eye surgery.

It selectively activates alpha‑2 adrenergic receptors in the ciliary body, reducing aqueous humor production and increasing uveoscleral outflow, which together lower intraocular pressure.

The dosing regimen is determined by the prescribing ophthalmologist based on the patient’s condition and response; typical regimens involve one to two drops per eye once or twice daily.

Safety data are limited; the product is classified as pregnancy category unknown, so it should be used only if the potential benefit justifies the potential risk, and breastfeeding mothers should consult their physician.

Submit an enquiry on the product page at gnhindia.com specifying the required quantity; GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with beta‑blocker drops, apraclonidine offers a different mechanism—alpha‑2 agonism—providing an alternative or adjunctive option, especially when beta‑blockers are contraindicated or insufficient alone.

Keep the ophthalmic solution at room temperature below 25 °C, in the original container, protected from light and moisture; do not freeze.

Instill the prescribed number of drops into the affected eye(s) as directed by the ophthalmologist, usually using a clean fingertip to avoid contaminating the tip, and avoid touching the eye or surrounding tissues.

Rare but serious adverse events include severe allergic reactions such as angioedema or anaphylaxis, persistent ocular inflammation, and marked systemic hypotension that can cause dizziness or fainting.

Patients with known hypersensitivity to apraclonidine or any excipients, and individuals with severe cardiovascular instability or uncontrolled low blood pressure should avoid using the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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