Product image of Iopidine (Apraclonidine Hydrochloride) supplied by GNH India

Iopidine

Active Ingredient:
Apraclonidine Hydrochloride
Origin:
EU

Iopidine (Apraclonidine Hydrochloride)

Apraclonidine, the active ingredient in Iopidine, is a alpha-2 adrenergic agonist presented as an ophthalmic solution for ocular use. It is employed to lower intra‑ocular pressure in patients with glaucoma or ocular hypertension.

GNH India supplies Iopidine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Essential Pharma Limited

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Indications & Clinical Uses

Iopidine is an ocular hypotensive agent used in the management of conditions that raise intra‑ocular pressure.

  • Glaucoma: reduces intra‑ocular pressure to help preserve visual field.
  • Ocular hypertension: lowers pressure in eyes without established glaucomatous damage.
  • Secondary ocular hypertension: controls pressure elevation secondary to ocular inflammation or trauma.

How It Works

  • Apraclonidine acts as a selective alpha‑2 adrenergic receptor agonist in the eye. Stimulation of these receptors decreases aqueous humor production and enhances uveoscleral outflow, resulting in a net reduction of intra‑ocular pressure.

Side Effects

Adverse reactions are generally mild to moderate, but serious events can occur.

Common Side Effects

  • Burning or stinging sensation at the instillation site.
  • Redness of the conjunctiva.
  • Blurred vision shortly after dosing.
  • Dry eye sensation.

Serious or Rare Side Effects

  • Allergic contact dermatitis of the eyelid.
  • Severe eye pain or corneal edema.
  • Persistent visual disturbance.
  • Systemic hypotension or bradycardia.
  • Rare cases of arrhythmia.

Precautions & Warnings

Use Iopidine only under the direction of an eye‑care professional and observe the following precautions.

  • Monitor intra‑ocular pressure: ensure adequate pressure reduction and adjust therapy as needed.
  • Cardiovascular disease: use with caution in patients with hypotension or bradycardia.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Concomitant ocular drugs: avoid unsupervised combination with other pressure‑lowering eye drops.
  • Storage: Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Apraclonidine may interact with other systemic or ocular agents.

Major Interactions (Avoid)

  • Systemic alpha‑2 agonists (e.g., clonidine): may cause additive hypotensive effects.
  • MAO inhibitors: increased risk of severe hypotension.

Moderate Interactions (Monitor Closely)

  • Topical beta‑blocker eye drops: potential for excessive IOP lowering.
  • Prostaglandin analogues: may require dose adjustment.
  • Oral antihypertensive medications: monitor blood pressure for additive effects.

Frequently Asked Questions

Iopidine is an ophthalmic solution containing apraclonidine that is prescribed to lower intra‑ocular pressure in patients with glaucoma or ocular hypertension, helping to protect the optic nerve and preserve vision.

Apraclonidine selectively stimulates alpha‑2 adrenergic receptors in the ciliary body, which reduces the production of aqueous humor and enhances uveoscleral outflow, leading to a decrease in intra‑ocular pressure.

The dosing regimen for Iopidine is determined by the prescribing eye‑care professional based on the patient’s condition, response, and tolerance. The prescriber will specify the number of drops and frequency.

Safety data for apraclonidine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Iopidine, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Iopidine (apraclonidine) is an alpha‑2 agonist, whereas many other glaucoma drops are beta‑blockers, prostaglandin analogues or carbonic anhydrase inhibitors. Apraclonidine primarily reduces aqueous humor production and can be used as adjunct therapy when other agents alone are insufficient.

Iopidine should be stored at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed in its original packaging until use.

Iopidine is applied as eye drops. The patient instills the prescribed number of drops into the affected eye(s) as directed by the ophthalmologist, typically avoiding contact with the eyelid or lashes.

Serious risks include allergic reactions such as contact dermatitis, severe eye pain or corneal edema, and systemic effects like hypotension or bradycardia, especially when used with other alpha‑2 agonists or antihypertensive drugs.

Patients with known hypersensitivity to apraclonidine or any component of the formulation should avoid Iopidine. Caution is also advised for individuals with severe cardiovascular disease, uncontrolled hypotension, or those taking systemic alpha‑2 agonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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