Product image of Iopidine (Apraclonidine Hydrochloride) supplied by GNH India

Iopidine

Active Ingredient:
Apraclonidine Hydrochloride
Origin:
EU

Iopidine (Apraclonidine Hydrochloride)

Apraclonidine hydrochloride, the active ingredient in Iopidine, is an alpha‑2 adrenergic agonist presented as an ophthalmic solution for ocular use. It reduces intra‑ocular pressure in glaucoma and ocular hypertension, and may be used as adjunctive therapy after ocular surgery.

GNH India supplies Iopidine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Products are manufactured under GMP conditions and are available for export to multiple regions, including the EU and Asia.

Manufacturer / TM Owner

Essential Pharma Limited

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Indications & Clinical Uses

Iopidine, an alpha‑2 adrenergic agonist, is used to lower intra‑ocular pressure in several ocular conditions.

  • Glaucoma: reduces intra‑ocular pressure to help prevent optic nerve damage.
  • Ocular hypertension: lowers pressure to reduce the risk of progression to glaucoma.
  • Post‑operative ocular surgery: adjunctive therapy to control IOP after procedures.

How It Works

  • Apraclonidine hydrochloride acts as a selective alpha‑2 adrenergic receptor agonist in the eye. Activation of these receptors decreases aqueous humor production by the ciliary body and enhances uveoscleral outflow, resulting in a net reduction of intra‑ocular pressure. The drug’s effect is rapid, typically observed within minutes, and it can be used alone or in combination with other IOP‑lowering agents to achieve target pressures.

Side Effects

Apraclonidine ophthalmic solution may cause ocular and systemic adverse reactions.

Common Side Effects

  • Eye irritation: transient burning or stinging after drop.
  • Redness: mild conjunctival hyperemia.
  • Blurred vision: temporary visual disturbance.

Serious or Rare Side Effects

  • Allergic reaction: swelling, rash, or severe eye inflammation.
  • Cardiovascular effects: hypotension or bradycardia (rare systemic absorption).
  • Severe ocular inflammation: uveitis or persistent pain.

Precautions & Warnings

When using Iopidine, several precautions should be observed to ensure safety and effectiveness.

  • Patient assessment: evaluate intra‑ocular pressure and glaucoma status before initiating therapy.
  • Contraindications: avoid in patients with known hypersensitivity to apraclonidine or other alpha‑2 agonists.
  • Monitoring: regularly check IOP and ocular health during treatment.
  • Systemic effects: be aware of possible cardiovascular changes, especially in patients with heart disease.
  • Drug interactions: review concomitant ocular medications for additive IOP‑lowering effects.
  • Store at room temperature: keep the solution below 25 °C, in the original container, protected from light and moisture.

Avoid Interactions

Apraclonidine may interact with other medications affecting ocular pressure or systemic adrenergic activity.

Major Interactions (Avoid)

  • Beta‑blocker eye drops: combined use may cause excessive IOP reduction.
  • Systemic alpha‑2 agonists (e.g., clonidine): additive hypotensive effects.

Moderate Interactions (Monitor Closely)

  • Carbonic anhydrase inhibitors: may enhance IOP‑lowering effect.
  • Topical non‑steroidal anti‑inflammatory drugs: could increase ocular irritation.
  • Anticholinergic agents: may affect pupil size and ocular comfort.

Frequently Asked Questions

Iopidine is an ophthalmic solution containing apraclonidine hydrochloride. It is prescribed to lower intra‑ocular pressure in conditions such as primary open‑angle glaucoma, ocular hypertension, and as an adjunct after ocular surgery to help maintain target pressure levels.

Apraclonidine acts as a selective alpha‑2 adrenergic receptor agonist in the eye. By stimulating these receptors, it reduces the production of aqueous humor and increases uveoscleral outflow, leading to a net decrease in intra‑ocular pressure.

The dosing regimen for Iopidine is determined by the prescribing eye‑care professional. Typically, the medication is administered as one or two drops in the affected eye(s) once or twice daily, but the exact schedule should follow the clinician’s instructions.

Safety data for apraclonidine in pregnancy and lactation are limited. The product is classified as pregnancy category unknown, so it should only be used if the potential benefit justifies the potential risk. Consultation with a healthcare provider is essential before use.

To order Iopidine, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Iopidine belongs to the alpha‑2 adrenergic agonist class, whereas many first‑line agents such as timolol are beta‑blockers. Apraclonidine primarily reduces aqueous humor production and enhances outflow, while beta‑blockers mainly decrease production. Choice of therapy depends on patient response, tolerability, and comorbid conditions.

Iopidine should be stored at room temperature, below 25 °C, in its original container. Protect the solution from direct light, moisture, and extreme temperatures to maintain stability and potency.

Iopidine is applied as an eye drop. The prescribed number of drops is placed into the conjunctival sac of the affected eye(s) using the provided dropper, typically without touching the eye or eyelid to maintain sterility.

Serious adverse reactions, although rare, include allergic eye inflammation, severe ocular inflammation such as uveitis, and systemic cardiovascular effects like hypotension or bradycardia. Patients should seek immediate medical attention if they experience swelling, severe pain, vision changes, or systemic symptoms.

Iopidine should not be used by individuals with a known hypersensitivity to apraclonidine or any component of the formulation. Caution is also advised for patients with severe cardiovascular disease, uncontrolled hypotension, or those taking systemic alpha‑2 agonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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