Product image of Ipaflex (Naproxen Sodium) supplied by GNH India

Ipaflex

Active Ingredient:
Naproxen Sodium
Origin:
EU

Ipaflex (Naproxen Sodium)

Naproxen Sodium, the active ingredient in Ipaflex, is a nonsteroidal anti‑inflammatory drug presented as an oral dosage form for oral use. It treats mild to moderate pain, inflammatory joint conditions such as osteoarthritis and rheumatoid arthritis, and reduces fever.
GNH India supplies Ipaflex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mcneil Sweden Ab

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Indications & Clinical Uses

Ipaflex, a nonsteroidal anti‑inflammatory drug, is employed in several common painful and inflammatory conditions.

  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, musculoskeletal aches and postoperative discomfort.
  • Osteoarthritis: reduces joint inflammation and improves mobility in degenerative joint disease.
  • Rheumatoid arthritis: alleviates inflammatory symptoms and joint swelling in autoimmune arthritis.
  • Fever: lowers elevated body temperature associated with infection or inflammation.

How It Works

  • Naproxen Sodium exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition decreases the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever, thereby providing analgesic, anti‑inflammatory, and antipyretic actions.

Side Effects

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Elevated blood pressure.
  • Skin rash or mild itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe allergic reactions: angioedema, anaphylaxis.
  • Hepatotoxicity: elevated liver enzymes.
  • Renal impairment: reduced kidney function.
  • Cardiovascular events: increased risk of thrombotic events.
  • Hematologic abnormalities: thrombocytopenia or anemia.

Precautions & Warnings

Before using Ipaflex, consider the following safety measures:

  • Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
  • Evaluate cardiovascular status: use cautiously in patients with heart disease or hypertension.
  • Monitor renal function: adjust use in patients with impaired kidney function.
  • Review concomitant medications: avoid combining with other NSAIDs or anticoagulants without medical advice.
  • Pregnancy and lactation: discuss risks with a healthcare professional before use.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: may reduce renal perfusion.
  • Lithium: naproxen can increase lithium serum levels.
  • Methotrexate: reduced clearance leading to toxicity.
  • Corticosteroids: additive risk of GI ulceration.
  • Antihypertensives: possible attenuation of blood‑pressure‑lowering effect.

Frequently Asked Questions

Ipaflex contains naproxen sodium, an NSAID that is commonly prescribed to relieve mild to moderate pain, reduce inflammation in osteoarthritis and rheumatoid arthritis, and lower fever associated with infections or inflammatory processes.

Naproxen sodium works by blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. By lowering prostaglandin levels, it diminishes pain signals, inflammation, and fever responses.

The exact dose of Ipaflex is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and overall health. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of naproxen sodium in pregnancy and lactation depends on the trimester and individual risk factors. It is generally advised to discuss use with a qualified healthcare provider, as the drug may be contraindicated in certain stages of pregnancy and may pass into breast milk.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Compared with other NSAIDs, naproxen sodium has a relatively long half‑life, allowing less frequent dosing for sustained pain relief. Its efficacy in reducing inflammation is similar to ibuprofen and diclofenac, but individual tolerance, gastrointestinal risk, and cardiovascular profile may differ among patients.

Ipaflex should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture, heat, and direct sunlight to maintain stability and potency.

Ipaflex is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce stomach upset. The exact administration schedule is set by the prescriber.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, kidney impairment, and increased cardiovascular events like heart attack or stroke. Patients should seek immediate medical attention if they experience symptoms such as vomiting blood, severe abdominal pain, or sudden swelling.

Ipaflex should be avoided in individuals with known hypersensitivity to naproxen or other NSAIDs, active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment unless specifically directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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