Product image of Iperten (Manidipine Dihydrochloride) supplied by GNH India

Iperten

Active Ingredient:
Manidipine Dihydrochloride
Origin:
EU

Iperten (Manidipine Dihydrochloride)

Manidipine Dihydrochloride, the active ingredient in Iperten, is a calcium channel blocker presented as an oral tablet for oral use. It works by relaxing arterial smooth muscle, thereby lowering blood pressure in adults with primary hypertension.

GNH India supplies Iperten as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and reliable global distribution.

Manufacturer / TM Owner

Chiesi Farmaceutici S.P.A.

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Indications & Clinical Uses

  • Manidipine, a dihydropyridine calcium channel blocker, is used in the management of arterial hypertension.
  • Hypertension: reduces systolic and diastolic blood pressure in patients with essential hypertension.

How It Works

  • Manidipine Dihydrochloride selectively blocks L‑type calcium channels in vascular smooth muscle, inhibiting calcium influx. This leads to arterial vasodilation, decreased peripheral vascular resistance, and ultimately a reduction in systemic blood pressure.

Side Effects

Manidipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate pain often occurring early in therapy.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness: sensation of light‑headedness, especially when standing.
  • Tachycardia: increased heart rate.
  • Nausea: mild gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Myocardial infarction: rare occurrence of heart attack.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Allergic reactions: rash, itching, or hives.
  • Angioedema: swelling of face, lips, or throat.
  • Cardiac arrhythmias: irregular heart rhythms.

Precautions & Warnings

Before initiating therapy with Manidipine, several safety considerations should be observed.

  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Hepatic impairment: use with caution; dose adjustment may be required.
  • Concomitant antihypertensives: evaluate risk of additive blood‑pressure lowering effects.
  • Renal function: assess in patients with renal disease.
  • Abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Manidipine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels.
  • Grapefruit juice: can elevate drug concentration.
  • Other potent vasodilators: risk of severe hypotension.
  • Non‑dihydropyridine calcium channel blockers: additive cardiac effects.
  • Alpha‑blockers: may cause excessive blood‑pressure drop.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce effectiveness.

  • Diuretics: monitor electrolytes and blood pressure.
  • Beta‑blockers: watch for bradycardia.
  • NSAIDs: may blunt antihypertensive response.
  • Antidiabetic agents: monitor glucose control.

Frequently Asked Questions

Iperten contains the active ingredient manidipine dihydrochloride, which is prescribed to lower high blood pressure in adult patients. It belongs to the calcium‑channel blocker class and is indicated for the treatment of essential (primary) hypertension.

Manidipine selectively blocks L‑type calcium channels in the smooth muscle of arteries. By preventing calcium entry, it causes arterial vasodilation, reduces peripheral vascular resistance, and consequently lowers systemic blood pressure.

The dosage of Iperten is individualized by a qualified prescriber based on the patient’s clinical condition, response to therapy, and any co‑existing medical issues. Patients should follow the prescribing information provided by their healthcare professional.

The safety of manidipine during pregnancy or lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a healthcare provider.

To request Iperten, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Iperten (manidipine) is a dihydropyridine calcium‑channel blocker, offering potent arterial vasodilation with a relatively favorable side‑effect profile compared with some beta‑blockers or ACE inhibitors. Choice of therapy depends on patient characteristics, comorbidities and physician preference.

Iperten should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keeping the product in a dry, temperature‑controlled environment helps maintain its stability and potency.

Iperten is taken orally, usually as a tablet, with or without food as directed by the prescribing clinician. Patients should swallow the tablet whole with a glass of water and avoid crushing or chewing unless specifically instructed.

Serious adverse events, although rare, can include severe hypotension, myocardial infarction, hepatic dysfunction, allergic reactions such as angio‑edema, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience symptoms like fainting, chest pain, or swelling of the face or throat.

Iperten is contraindicated in patients with known hypersensitivity to manidipine or any component of the formulation, and should be used with caution in individuals with severe hepatic impairment, unstable angina, or a history of serious cardiac arrhythmias. A healthcare professional must evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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