Product image of Ipertrofan (Mepartricin) supplied by GNH India

Ipertrofan

Active Ingredient:
Mepartricin
Origin:
EU

Ipertrofan (Mepartricin)

Mepartricin, the active ingredient in Ipertrofan, is an anthelmintic presented as an oral formulation for oral use. It is employed to treat intestinal helminth infections and to alleviate symptoms of chronic prostatitis in adult patients. The product conforms to European Union pharmaceutical standards and is marketed for use in adult populations.

GNH India supplies Ipertrofan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide, ensuring quality assurance, regulatory compliance, and reliable logistics for global distribution, and provides comprehensive post‑sale support.

Manufacturer / TM Owner

Spa – Società Prodotti Antibiotici S.P.A.

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Indications & Clinical Uses

  • Mepartricin is used to manage parasitic infections and related urological conditions.
  • Intestinal helminth infections: eliminates nematodes such as Ascaris, hookworm, and pinworm, reducing gastrointestinal symptoms.
  • Chronic prostatitis: alleviates pelvic pain and inflammation associated with non‑bacterial prostatitis.
  • Parasitic gastrointestinal disorders: controls worm burden in mixed infections, supporting overall gut health.

How It Works

  • Mepartricin exerts its antiparasitic effect by binding to parasite‑specific ion channels, particularly glutamate‑gated chloride channels, which increases chloride ion influx, hyperpolarizes the neuronal membrane, and leads to paralysis and death of the worm. In the prostate, the compound modulates inflammatory pathways, reducing cytokine production and smooth‑muscle spasm, which contributes to symptom relief in chronic prostatitis. The drug’s selective affinity for parasite receptors minimizes impact on human host cells.

Side Effects

Mepartricin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate feeling of sickness.
  • Abdominal discomfort: cramps or pain in the stomach area.
  • Diarrhea: loose stools occurring after dosing.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): difficulty breathing, swelling, rash.
  • Hepatotoxicity: marked increase in liver enzymes, jaundice.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.

Precautions & Warnings

Before prescribing Mepartricin, consider the following precautions to ensure safe use.

  • Pregnancy: use only if potential benefit justifies the risk; data are limited.
  • Breastfeeding: caution advised as drug may be excreted in milk.
  • Liver impairment: assess hepatic function and monitor enzymes during therapy.
  • Renal impairment: adjust dosage if severe renal dysfunction is present.
  • Drug interactions: review concomitant medications for potential additive toxicity.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture and light.

Avoid Interactions

Mepartricin can interact with other medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Co‑administration with other anthelmintics: may increase neurotoxicity.
  • Strong CYP450 inducers (e.g., rifampicin): may reduce Mepartricin plasma levels.
  • Anticholinergic agents: can exacerbate gastrointestinal side effects.

Moderate Interactions (Monitor Closely)

  • Antibiotics altering gut flora (e.g., broad‑spectrum penicillins): may affect parasite load and drug efficacy.
  • Antifungal azoles (e.g., ketoconazole): potential to modify metabolism.
  • NSAIDs: increased risk of gastrointestinal irritation.

Frequently Asked Questions

Ipertrofan contains the anthelmintic mepartricin and is used to treat intestinal helminth infections such as ascariasis, hookworm and pinworm, as well as to relieve symptoms of chronic non‑bacterial prostatitis in adult patients.

Mepartricin binds to parasite‑specific ion channels, especially glutamate‑gated chloride channels, causing an influx of chloride ions that hyperpolarizes the worm’s nerve and muscle cells, leading to paralysis and death. In the prostate, it modulates inflammatory pathways, reducing cytokine release and smooth‑muscle spasm.

The dosage of Ipertrofan is determined by the prescribing healthcare professional based on the specific infection, patient weight, age, and renal or hepatic function. Patients should follow the exact regimen provided by their doctor and not adjust the dose on their own.

Safety data for mepartricin in pregnancy are limited; it should only be used if the potential benefit outweighs any possible risk to the fetus. During breastfeeding, caution is advised because the drug may be secreted in breast milk, and a healthcare provider should evaluate the risk‑benefit balance.

To request Ipertrofan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older anthelmintics such as albendazole, mepartricin offers a broader spectrum against certain nematodes and may provide additional anti‑inflammatory benefits in chronic prostatitis. However, choice of therapy depends on the parasite species, resistance patterns, patient tolerance and clinical guidelines.

Ipertrofan should be stored at ambient temperature, preferably below 25 °C, in its original container to protect it from moisture, light and excessive heat. Keeping the product in a dry place helps maintain its potency throughout its shelf life.

Ipertrofan is taken orally, usually with a glass of water. The tablet or capsule should be swallowed whole unless the prescriber advises otherwise. Administration timing relative to meals may be specified by the healthcare provider to optimise absorption.

The most serious adverse reactions include severe allergic responses such as anaphylaxis, hepatotoxicity indicated by marked liver enzyme elevations, and rare skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience breathing difficulty, jaundice, or extensive skin blistering.

Ipertrofan is contraindicated in individuals with known hypersensitivity to mepartricin or any excipients, in patients with severe hepatic or renal impairment unless dose adjustments are made, and in pregnant women unless the potential benefit justifies the risk. Children under the approved age limit should also avoid use unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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