Product image of Ipertrofan (Mepartricin) supplied by GNH India

Ipertrofan

Active Ingredient:
Mepartricin
Origin:
EU

Ipertrofan (Mepartricin)

Mepartricin, the active ingredient in Ipertrofan, is an anthelmintic presented as an oral tablet for oral use. It belongs to the macrocyclic lactone class and exhibits broad‑spectrum activity against intestinal nematodes and cestodes, treating infections in both adult and pediatric patients.

GNH India supplies Ipertrofan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Prospa - Laboratórios Farmacêuticos, S.A.

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Indications & Clinical Uses

Mepartricin is an anthelmintic that targets parasitic helminths in the gastrointestinal tract.

  • Ascariasis: eradicates Ascaris lumbricoides infection, reducing worm burden and associated symptoms.
  • Hookworm infection: eliminates Ancylostoma duodenale and Necator americanus, improving anemia and gastrointestinal discomfort.
  • Trichuriasis: clears Trichuris trichiura infestation, alleviating abdominal pain and dysentery.
  • Chronic prostatitis/chronic pelvic pain syndrome: may reduce inflammatory symptoms and improve quality of life in affected males.

How It Works

  • Mepartricin binds to glutamate‑gated chloride channels on the membranes of nematodes and cestodes, causing uncontrolled chloride influx that leads to parasite paralysis and death. It also interferes with prostaglandin synthesis and other inflammatory mediators, contributing to its anti‑inflammatory effect in the prostate.

Side Effects

Mepartricin may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Nausea: mild stomach upset or queasiness.
  • Abdominal pain: cramping or discomfort in the abdomen.
  • Diarrhea: loose stools occurring during or after treatment.
  • Headache: transient mild to moderate headache.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or jaundice indicating liver injury.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis in susceptible individuals.
  • Severe neutropenia: marked reduction in white blood cells, increasing infection risk.

Precautions & Warnings

Before prescribing Mepartricin, clinicians should consider several precautionary measures to ensure safe use.

  • Hypersensitivity: avoid use in patients with known allergy to mepartricin or related macrocyclic lactones.
  • Liver disease: use with caution in patients with hepatic impairment; monitor liver function tests.
  • Pregnancy: insufficient data; avoid unless potential benefit justifies potential risk.
  • Pediatric use: dosage and safety not established for children under 2 years; use only under specialist supervision.
  • Drug interactions: review concomitant medications for potential interactions (see interaction section).
  • Store at ambient temperature: keep below 25 °C, protect from moisture and direct sunlight in original packaging.

Avoid Interactions

Mepartricin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Concurrent anthelmintics: combined use may increase neurotoxicity and risk of severe adverse reactions.
  • Warfarin: may potentiate anticoagulant effect, increasing bleeding risk.

Moderate Interactions (Monitor Closely)

  • CYP450 substrates: mepartricin may inhibit certain enzymes, altering plasma levels of drugs metabolized by CYP3A4.
  • Antacids containing aluminum or magnesium: may reduce absorption of mepartricin, decreasing therapeutic effect.
  • CNS depressants: additive sedative effects possible; monitor patient for excessive drowsiness.

Frequently Asked Questions

Ipertrofan contains the active ingredient mepartricin, an anthelmintic used to treat a variety of intestinal helminth infections such as ascariasis, hookworm, and trichuriasis. It may also be prescribed for inflammatory conditions of the prostate in some clinical settings.

Mepartricin acts by binding to glutamate‑gated chloride channels on parasitic worms, causing an uncontrolled influx of chloride ions that leads to paralysis and death of the parasite. It also modulates inflammatory pathways, which can help reduce prostate inflammation in certain cases.

The dosage of Ipertrofan is determined by the prescribing clinician based on the specific infection, patient age, weight, and overall health. Dosage instructions are provided on the prescription label and should be followed exactly as directed by a healthcare professional.

Safety data for mepartricin in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers should evaluate each case individually and discuss possible alternatives.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and necessary import documentation.

Ipertrofan (mepartricin) offers a broad spectrum of activity against both nematodes and cestodes, similar to other macrocyclic lactones. Compared with some benzimidazole agents, it may have a different safety profile and can be useful when resistance to other classes is suspected.

Ipertrofan tablets should be stored at ambient temperature, below 25 °C, in their original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain potency and stability.

Ipertrofan is taken orally, usually with a glass of water. The tablet should be swallowed whole unless otherwise instructed by a healthcare professional. Food may be taken with the dose, but patients should follow any specific guidance on timing relative to meals.

Serious risks include hepatotoxicity, severe allergic reactions such as anaphylaxis, and rare cases of neutropenia. Patients should be monitored for signs of liver dysfunction, rash, swelling, or unexplained infections, and seek medical attention promptly if these occur.

Ipertrofan should not be used by individuals with a known hypersensitivity to mepartricin or related macrocyclic lactones. Caution is advised in patients with significant liver disease, and it is generally avoided in pregnant or breastfeeding women unless clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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