Product image of Ipinzan (Metformin Hydrochloride, Vildagliptin) supplied by GNH India

Ipinzan

Active Ingredient:
Metformin Hydrochloride, Vildagliptin
Origin:
EU

Ipinzan (Metformin Hydrochloride, Vildagliptin)

Metformin Hydrochloride and Vildagliptin, the active ingredients in Ipinzan, are a Biguanide and DPP‑4 inhibitor presented as an oral tablet for oral administration. They are used to treat type 2 diabetes mellitus in adult patients by lowering elevated blood glucose levels.

GNH India supplies Ipinzan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows stringent quality‑assurance protocols and provides full regulatory documentation to facilitate global procurement and distribution, including batch release certificates and stability data for each shipment.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Ipinzan, containing metformin and vildagliptin, is employed in the management of type 2 diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia.

  • Type 2 diabetes mellitus: improves overall glycemic control when diet and exercise alone are insufficient.
  • Hyperglycemia: reduces fasting and post‑prandial blood glucose levels.
  • Adjunct therapy: can be combined with other antidiabetic agents to achieve target HbA1c.

How It Works

  • Metformin decreases hepatic gluconeogenesis and enhances peripheral insulin sensitivity, thereby lowering glucose production. Vildagliptin selectively inhibits the enzyme dipeptidyl peptidase‑4 (DPP‑4), which prolongs the activity of endogenous incretin hormones (GLP‑1 and GIP). The increased incretin effect stimulates glucose‑dependent insulin secretion and suppresses glucagon release, together providing complementary glucose‑lowering actions. These mechanisms act synergistically to achieve better glycemic control than either agent alone.

Side Effects

Ipinzan may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or diarrhea.
  • Headache: mild to moderate headache episodes.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Lactic acidosis: rare but potentially fatal metabolic complication.
  • Severe hypoglycemia: especially when combined with insulin or sulfonylureas.
  • Pancreatitis: inflammation of the pancreas presenting with abdominal pain.
  • Skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

When prescribing Ipinzan, several precautionary measures should be observed to minimize risk.

  • Renal function assessment: evaluate eGFR before initiation and periodically thereafter.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Risk of lactic acidosis: avoid in patients with severe renal or hepatic dysfunction.
  • Hypoglycemia monitoring: educate patients on signs, especially if combined with other glucose‑lowering drugs.
  • Elderly patients: start at lower dose and titrate slowly.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Ipinzan can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast media: may precipitate lactic acidosis; discontinue metformin before use.
  • Cimetidine: can increase metformin plasma levels, raising risk of adverse effects.
  • Alcohol: potentiates risk of lactic acidosis when combined with metformin.

Moderate Interactions (Monitor Closely)

  • Sulfonylureas or insulin: increased risk of hypoglycemia; adjust dose as needed.
  • Beta‑blockers: may mask hypoglycemia symptoms.
  • Diuretics: can affect renal function, influencing metformin clearance.
  • NSAIDs: may impair renal function and increase metformin exposure.

Frequently Asked Questions

Ipinzan is indicated for the treatment of type 2 diabetes mellitus in adult patients. It helps lower elevated blood glucose levels when diet, exercise, and lifestyle measures alone are insufficient to achieve glycemic targets.

Metformin reduces hepatic glucose production and improves peripheral insulin sensitivity, while Vildagliptin inhibits the DPP‑4 enzyme, prolonging the action of incretin hormones that increase insulin secretion and suppress glucagon release. Together they provide complementary glucose‑lowering effects.

The appropriate dose of Ipinzan is individualized by the prescribing healthcare professional based on the patient’s renal function, glycemic control, concomitant medications, and overall clinical condition. No fixed dosing regimen is provided here.

Safety of Ipinzan in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made in consultation with a qualified healthcare provider.

To request Ipinzan, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ipinzan combines a Biguanide (metformin) with a DPP‑4 inhibitor (vildagliptin), offering dual mechanisms that can achieve better glycemic control than metformin alone and with a lower risk of hypoglycemia compared with sulfonylureas. It is an alternative to fixed‑dose combinations of metformin with other DPP‑4 inhibitors.

Ipinzan tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children.

Ipinzan is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets are swallowed whole with a glass of water. The exact timing and frequency are determined by the prescribing clinician.

The most serious adverse events include lactic acidosis, which is rare but potentially fatal, severe hypoglycemia when used with insulin or sulfonylureas, and acute pancreatitis. Patients should be educated to recognize symptoms and seek immediate medical attention if they occur.

Ipinzan should be avoided in patients with severe renal impairment (eGFR <30 mL/min/1.73 m²), known hypersensitivity to metformin, vildagliptin, or any component of the formulation, and in individuals with a history of lactic acidosis. Caution is also advised in patients with significant hepatic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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