Product image of Ipramol (Ipratropium Bromide, Salbutamol) supplied by GNH India

Ipramol

Active Ingredient:
Ipratropium Bromide, Salbutamol
Origin:
EU

Ipramol (Ipratropium Bromide, Salbutamol)

Ipratropium bromide / Salbutamol, the active ingredients in Ipramol, constitute a bronchodilator (combination anticholinergic and β2‑agonist) presented as a combination formulation for inhalation and oral administration. It helps relieve bronchoconstriction and improve airflow in patients with asthma and chronic obstructive pulmonary disease (COPD).

GNH India supplies Ipramol as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide from its EU‑origin market. The company adheres to stringent quality standards and supports global distribution networks. All shipments are accompanied by full regulatory documentation.

Manufacturer / TM Owner

Teva Pharma – Produtos Farmacêuticos Lda

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Indications & Clinical Uses

Ipramol, a combination bronchodilator, is used to manage obstructive airway diseases by relaxing airway smooth muscle.

  • Asthma: improves airflow and reduces symptoms such as wheezing and shortness of breath.
  • Chronic obstructive pulmonary disease (COPD): alleviates chronic bronchoconstriction and enhances exercise tolerance.
  • Acute bronchospasm: provides rapid bronchodilation during sudden airway narrowing episodes.

How It Works

  • Ipramol combines ipratropium bromide, an anticholinergic that competitively blocks muscarinic (M3) receptors on airway smooth muscle, preventing acetylcholine‑mediated bronchoconstriction, with salbutamol, a selective β2‑adrenergic agonist that stimulates adenylate cyclase via β2 receptors, increasing cAMP and causing relaxation of airway smooth muscle. The complementary actions produce additive bronchodilation, improving airflow in obstructive airway conditions.

Side Effects

Ipramol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dry mouth.
  • Tremor or shakiness.
  • Headache.
  • Throat irritation or cough.
  • Palpitations.

Serious or Rare Side Effects

  • Paradoxical bronchospasm.
  • Significant tachycardia or arrhythmia.
  • Allergic reactions such as rash, angioedema, or anaphylaxis.

Precautions & Warnings

Use Ipramol with clinical caution and monitor patients for specific concerns.

  • Dose adjustment in renal impairment: monitor for accumulation and possible increased anticholinergic effects.
  • Cardiovascular disease: use carefully as the β2‑agonist component may raise heart rate and blood pressure.
  • Narrow‑angle glaucoma: anticholinergic action can increase intra‑ocular pressure; avoid in susceptible patients.
  • Pregnancy and breastfeeding: safety not established; prescribe only if benefit outweighs potential risk.
  • Drug interactions: review concomitant β‑agonists or anticholinergics to prevent additive effects.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat, and store below 25 °C.

Avoid Interactions

Ipramol can interact with several medicines; some combinations require avoidance while others need monitoring.

Major Interactions (Avoid)

  • MAO inhibitors: may precipitate hypertensive crisis.
  • Non‑selective beta‑blockers: can diminish bronchodilator efficacy and provoke bronchospasm.
  • Tricyclic antidepressants: increased anticholinergic load may exacerbate dry mouth and urinary retention.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypokalemia when combined with β2‑agonist.
  • Theophylline: additive tachycardia and tremor risk.
  • Other anticholinergic agents: may increase dryness of mucous membranes.

Frequently Asked Questions

Ipramol is a combination bronchodilator containing ipratropium bromide and salbutamol. It is prescribed to relieve bronchoconstriction and improve airflow in patients with asthma, chronic obstructive pulmonary disease (COPD), and acute bronchospasm episodes.

Ipratropium bromide blocks muscarinic (M3) receptors on airway smooth muscle, preventing acetylcholine‑induced tightening. Salbutamol stimulates β2‑adrenergic receptors, raising cyclic AMP levels and causing smooth‑muscle relaxation. The dual action yields additive bronchodilation, easing breathing in obstructive airway conditions.

The dose of Ipramol is determined by the prescribing clinician based on the patient’s age, disease severity, and response to therapy. Healthcare professionals select the appropriate strength, frequency, and route of administration according to clinical guidelines.

Safety data for ipratropium bromide and salbutamol in pregnancy and lactation are limited. The product should be used only if the potential benefit justifies any potential risk to the fetus or infant, and under the guidance of a qualified healthcare provider.

To order Ipramol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Ipramol combines an anticholinergic (ipratropium) with a β2‑agonist (salbutamol), offering broader bronchodilation than either component alone. Compared with single‑agent inhalers, the combination can provide faster symptom relief and may reduce the need for higher doses of individual agents, though cost and device preference also influence choice.

Store Ipramol at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, heat and direct sunlight, and ensure the container is tightly closed when not in use.

Ipramol is delivered by inhalation using a metered‑dose inhaler or nebulizer, and may also be available in oral form for specific formulations. Patients should follow the inhalation technique instructed by their healthcare provider to ensure optimal drug deposition in the lungs.

Serious adverse events include paradoxical bronchospasm, significant tachycardia or arrhythmias, and severe allergic reactions such as anaphylaxis or angioedema. Patients should seek immediate medical attention if they experience worsening breathing, rapid heartbeat, or signs of an allergic response.

Ipramol is contraindicated in individuals with known hypersensitivity to ipratropium, salbutamol, or any excipients. It should also be avoided in patients with narrow‑angle glaucoma, severe cardiovascular disease, or those who have experienced a prior paradoxical bronchospasm with similar agents.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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