Product image of Ipramol Steri-Neb (Ipratropium Bromide, Salbutamol) supplied by GNH India

Ipramol Steri-Neb

Active Ingredient:
Ipratropium Bromide, Salbutamol
Origin:
EU

Ipramol Steri-Neb (Ipratropium Bromide, Salbutamol)

Ipratropium bromide and Salbutamol, the active ingredients in Ipramol Steri‑Neb, are a combination bronchodilator presented as a nebulizer solution for inhalation use. They relieve bronchospasm in patients with chronic obstructive pulmonary disease (COPD) and asthma by relaxing airway smooth muscle. The formulation provides rapid onset of action and is indicated for acute episodes of bronchoconstriction.

GNH India supplies Ipramol Steri‑Neb as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Ipramol Steri‑Neb, a combination bronchodilator, acts on the airway smooth muscle to alleviate bronchospasm in obstructive lung diseases.

  • COPD: reduces bronchoconstriction and improves airflow during acute exacerbations.
  • Asthma: relieves acute bronchospasm and facilitates breathing in asthma attacks.
  • Other respiratory bronchospasm: helps open airways in various conditions causing bronchoconstriction.

How It Works

  • Ipramol Steri‑Neb combines ipratropium bromide, a muscarinic antagonist that blocks acetylcholine receptors in bronchial smooth muscle, with salbutamol, a selective β2‑adrenergic agonist that stimulates β2 receptors to increase cyclic AMP and relax airway smooth muscle, resulting in bronchodilation.

Side Effects

Ipramol Steri‑Neb may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Cough or throat irritation: mild discomfort during inhalation.
  • Dry mouth: reduced salivation after use.
  • Tremor: fine shaking of hands or limbs.
  • Headache: mild to moderate pain.
  • Palpitations: sensation of rapid heartbeat.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Paradoxical bronchospasm: worsening of breathing difficulty.
  • Severe tachycardia or arrhythmia: rapid or irregular heart rhythm.
  • Angioedema or anaphylaxis: swelling of face, lips, or throat requiring emergency care.

Precautions & Warnings

When using Ipramol Steri‑Neb, certain precautions should be observed to ensure safe administration.

  • Cardiac assessment: monitor heart rate and blood pressure in patients with cardiovascular disease.
  • Glaucoma caution: avoid use in patients with narrow‑angle glaucoma due to anticholinergic effects.
  • Diabetes monitoring: observe blood glucose levels as salbutamol may raise glucose.
  • Concomitant beta‑blockers: be aware that non‑selective beta‑blockers can diminish bronchodilator effect.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Ipramol Steri‑Neb can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: may antagonize the bronchodilator effect and precipitate bronchospasm.
  • MAO inhibitors: combined use can increase the risk of severe hypertension.
  • Other anticholinergic agents: may enhance anticholinergic side effects.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypokalemia caused by salbutamol.
  • Theophylline: concurrent use can increase risk of cardiac arrhythmias.
  • ACE inhibitors: may increase cough and bronchial irritation.

Frequently Asked Questions

Ipramol Steri‑Neb is a nebulized combination of ipratropium bromide and salbutamol indicated for the relief of bronchospasm in patients with chronic obstructive pulmonary disease (COPD) and asthma. It works by relaxing airway smooth muscle, providing rapid improvement in breathing during acute episodes.

Ipratropium bromide is a muscarinic antagonist that blocks acetylcholine receptors in the bronchial smooth muscle, preventing cholinergic‑mediated bronchoconstriction. By inhibiting this pathway, it helps keep the airways open and reduces mucus secretion.

Salbutamol is a selective β2‑adrenergic agonist that stimulates β2 receptors on airway smooth muscle, leading to increased cyclic AMP and relaxation of the bronchial muscles. This produces rapid bronchodilation and eases breathing.

The dosage of Ipramol Steri‑Neb is determined by the prescribing healthcare professional based on the patient’s age, severity of bronchospasm, and clinical response. The prescriber will specify the volume to be nebulized, frequency, and duration of each treatment session.

Safety data for ipratropium bromide and salbutamol during pregnancy or lactation are limited, and the product should only be used if the potential benefit justifies any potential risk to the fetus or infant. Consultation with a physician is essential before use in pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Compared with single‑agent bronchodilators, the ipratropium‑salbutamol combination offers complementary mechanisms—anticholinergic and β2‑agonist—resulting in enhanced bronchodilation and reduced need for higher doses of either agent alone. This can improve symptom control in COPD and asthma.

Store the nebulizer solution below 25 °C in its original container, protected from moisture and direct light. Do not freeze the product, and keep it out of reach of children.

The solution is placed in a compatible nebulizer device, attached to a compressor, and inhaled through a mouthpiece or mask as directed by the prescriber. The typical session lasts several minutes, delivering the medication directly to the lungs.

Serious adverse reactions can include paradoxical bronchospasm, severe tachycardia or arrhythmias, and hypersensitivity reactions such as angioedema or anaphylaxis. Patients experiencing these symptoms should discontinue use and seek immediate medical attention.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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