Product image of Ipramol Steri-Neb (Ipratropium Bromide, Salbutamol) supplied by GNH India

Ipramol Steri-Neb

Active Ingredient:
Ipratropium Bromide, Salbutamol
Origin:
EU

Ipramol Steri-Neb (Ipratropium Bromide, Salbutamol)

Ipratropium bromide and salbutamol, the active ingredients in Ipramol Steri-Neb, are a combination bronchodilator presented as an inhalation solution for inhalation use. It treats bronchospasm associated with chronic obstructive pulmonary disease and asthma in adult patients.

GNH India supplies Ipramol Steri-Neb as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Nederland B.V.

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Indications & Clinical Uses

Ipramol Steri-Neb, a combination bronchodilator, is used to manage airway obstruction in obstructive lung diseases.

  • COPD: reduces bronchospasm and improves airflow during acute exacerbations.
  • Asthma: provides rapid relief of bronchoconstriction in acute asthma attacks.
  • Acute bronchospasm: offers prompt bronchodilation to alleviate sudden airway narrowing.

How It Works

  • Ipratropium bromide blocks muscarinic receptors on airway smooth muscle, preventing acetylcholine‑mediated bronchoconstriction, while salbutamol stimulates β2‑adrenergic receptors, leading to relaxation of bronchial smooth muscle and bronchodilation. The combined actions produce additive improvement in airway caliber.

Side Effects

Adverse reactions to Ipramol Steri-Neb may vary in frequency and severity.

Common Side Effects

  • Dry mouth: sensation of dryness in the oral cavity.
  • Cough: transient irritation leading to coughing.
  • Throat irritation: discomfort or soreness in the throat.
  • Tremor: mild shaking of hands or limbs.
  • Headache: mild to moderate head pain.
  • Palpitations: awareness of heart beating faster or irregularly.

Serious or Rare Side Effects

  • Paradoxical bronchospasm: worsening of airway constriction after inhalation.
  • Tachyarrhythmia: rapid or irregular heart rhythm.
  • Angioedema: swelling of face, lips, or airway.
  • Severe hypersensitivity: rash, itching, or anaphylactic reaction.
  • Cardiac ischemia: chest pain due to reduced heart blood flow.

Precautions & Warnings

Before prescribing Ipramol Steri-Neb, clinicians should consider several safety precautions.

  • Cardiac assessment: evaluate for existing heart disease or arrhythmias.
  • Glaucoma caution: avoid in patients with narrow‑angle glaucoma.
  • Monitor paradoxical bronchospasm: watch for worsening breathing after first dose.
  • Hypersensitivity screening: ensure no known allergy to ipratropium or salbutamol.
  • Use with caution in severe COPD: adjust therapy based on response.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Ipramol Steri-Neb can interact with other medicines; some combinations require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: may diminish bronchodilator effect and provoke bronchospasm.
  • MAO inhibitors: increase risk of cardiovascular side effects when combined with salbutamol.
  • Anticholinergic overload: concurrent use of other anticholinergics can enhance dry‑mouth and urinary retention.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate hypokalemia induced by salbutamol.
  • Theophylline: combined use can increase risk of tachycardia and tremor.
  • Tricyclic antidepressants: may potentiate cardiovascular effects.
  • Digoxin: salbutamol may raise serum digoxin levels, requiring monitoring.

Frequently Asked Questions

Ipramol Steri-Neb is a prescription inhalation product that combines ipratropium bromide and salbutamol to relieve bronchospasm in patients with chronic obstructive pulmonary disease (COPD) and asthma. It provides rapid bronchodilation during acute episodes and can be used as a rescue medication to improve breathing.

Ipratropium bromide is an anticholinergic agent that blocks muscarinic (M3) receptors on airway smooth muscle. By preventing acetylcholine‑mediated contraction, it reduces bronchoconstriction and helps keep the airways open, especially in COPD where cholinergic tone is high.

Salbutamol is a short‑acting β2‑adrenergic agonist. It binds to β2 receptors on bronchial smooth muscle, activating adenylate cyclase, increasing cyclic AMP, and causing muscle relaxation. This leads to quick bronchodilation, relieving acute asthma symptoms and exercise‑induced bronchospasm.

The prescribed dose of Ipramol Steri-Neb is determined by the treating physician based on the patient’s condition, severity of symptoms, and response to therapy. Typical regimens involve one or two inhalations as needed for relief, but exact dosing must follow the clinician’s order.

Safety data for ipratropium bromide and salbutamol during pregnancy and lactation are limited, and the product is classified as “unknown” for pregnancy. Use only if the potential benefit justifies the potential risk to the fetus or infant, and discuss with a healthcare professional.

To order Ipramol Steri-Neb, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ipramol Steri-Neb combines an anticholinergic (ipratropium) with a β2‑agonist (salbutamol), offering additive bronchodilation compared with single‑agent inhalers. This dual mechanism can provide faster and more sustained relief than either component alone, making it useful for patients who need both pathways targeted.

Store Ipramol Steri-Neb at ambient temperature, preferably below 25 °C, in its original container. Protect the product from moisture, direct sunlight, and extreme temperatures. Keep the device clean according to the manufacturer’s instructions to maintain dose accuracy.

The medication is delivered by inhalation using a metered‑dose inhaler or nebulizer, as directed by the prescriber. The patient inhales the dose deeply and holds the breath for a few seconds to allow optimal drug deposition in the lower airways.

Serious risks include paradoxical bronchospasm, which can worsen breathing shortly after inhalation, and cardiovascular events such as tachyarrhythmia or angina, especially in patients with pre‑existing heart disease. Any signs of severe allergic reaction, swelling of the face or throat, or persistent chest pain require immediate medical attention.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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