Product image of Ipratropio Bromuro Cipla (Ipratropium Bromide Monohydrate) supplied by GNH India

Ipratropio Bromuro Cipla

Active Ingredient:
Ipratropium Bromide Monohydrate
Origin:
EU

Ipratropio Bromuro Cipla (Ipratropium Bromide Monohydrate)

Ipratropium bromide, the active ingredient in Ipratropio Bromuro Cipla, is an anticholinergic presented as an inhalation solution for inhalation use. It produces bronchodilation by blocking muscarinic receptors, helping to control symptoms of chronic obstructive pulmonary disease (COPD) and asthma in adult patients.

GNH India supplies Ipratropio Bromuro Cipla as a licensed, GMP‑certified, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, and clinics worldwide under strict quality and regulatory standards. The company’s global logistics network ensures timely delivery and compliance with import regulations across multiple regions.

Manufacturer / TM Owner

Cipla Europe Nv

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Indications & Clinical Uses

Ipratropium bromide is an anticholinergic bronchodilator used in the management of obstructive airway diseases.

  • Chronic obstructive pulmonary disease (COPD): improves airflow and reduces the frequency of exacerbations.
  • Asthma: provides additional bronchodilation as add‑on therapy to improve symptom control.
  • Chronic bronchitis: helps relieve bronchospasm and enhances breathing comfort.

How It Works

  • Ipratropium bromide acts as a competitive antagonist at muscarinic (M3) receptors on airway smooth muscle. By blocking acetylcholine binding, it prevents calcium‑mediated contraction, leading to relaxation of bronchial smooth muscle and bronchodilation. The drug remains largely in the pulmonary tract, providing a localized effect with minimal systemic absorption.

Side Effects

Ipratropium bromide may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Dry mouth: sensation of reduced salivation.
  • Cough: irritation of the throat during inhalation.
  • Throat irritation: mild soreness or discomfort.
  • Headache: transient mild headache.
  • Dizziness: occasional light‑headed feeling.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Paradoxical bronchospasm: sudden worsening of breathing.
  • Urinary retention: difficulty emptying the bladder.
  • Exacerbation of narrow‑angle glaucoma: increased intra‑ocular pressure.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Tachycardia: rapid heart rate in susceptible individuals.

Precautions & Warnings

Before prescribing ipratropium bromide, clinicians should consider several safety aspects.

  • Assess renal function: adjust use in severe renal impairment.
  • Monitor for anticholinergic effects: watch for dry mouth, constipation, or blurred vision.
  • Avoid use in patients with narrow‑angle glaucoma: may worsen intra‑ocular pressure.
  • Use with caution in patients with urinary retention: may exacerbate symptoms.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ipratropium bromide can interact with other medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent use with other anticholinergic agents: may increase anticholinergic burden.
  • Combination with beta‑agonists: may cause additive bronchodilation and potential tachycardia.
  • Use with MAO inhibitors: limited data, avoid unless necessary.

Moderate Interactions (Monitor Closely)

  • Inhaled corticosteroids: monitor for local irritation.
  • Diuretics: may increase risk of dry mouth.
  • Ophthalmic anticholinergics: monitor intra‑ocular pressure in glaucoma patients.

Frequently Asked Questions

Ipratropio Bromuro Cipla contains ipratropium bromide, an anticholinergic bronchodilator indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD) and as an add‑on therapy for asthma. It helps open the airways, reducing breathlessness and improving airflow.

Ipratropium bromide works by competitively blocking muscarinic (M3) receptors on airway smooth muscle. This inhibition prevents acetylcholine‑induced calcium influx, leading to relaxation of bronchial smooth muscle and bronchodilation, thereby easing airflow obstruction.

The prescribed dose of Ipratropio Bromuro Cipla is determined by the treating physician based on the patient’s condition, severity, and response to therapy. Typical regimens involve inhalation several times daily, but exact dosing must follow the prescriber’s instructions.

Safety data for ipratropium bromide in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit justifies any possible risk, and a healthcare professional should be consulted.

To order Ipratropio Bromuro Cipla, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and required import documentation.

Ipratropio Bromuro Cipla (ipratropium) is a short‑acting anticholinergic, whereas beta‑agonists such as albuterol provide rapid bronchodilation via a different receptor pathway. Long‑acting anticholinergics like tiotropium have a longer duration of action. Ipratropium is often used as add‑on therapy to achieve complementary bronchodilation.

Store the inhalation solution at room temperature, preferably below 25 °C, in the original container. Protect it from moisture, direct sunlight, and extreme temperatures. Keep the product out of reach of children and do not use after the expiration date.

The product is administered by inhalation, typically using a nebulizer or a metered‑dose inhaler as directed by a healthcare professional. The patient inhales the prescribed dose through the mouthpiece, ensuring proper technique to maximize drug delivery to the lungs.

Serious risks include paradoxical bronchospasm, urinary retention, exacerbation of narrow‑angle glaucoma, and severe allergic reactions such as anaphylaxis. Patients should be instructed to seek immediate medical attention if they experience sudden worsening of breathing, eye pain, difficulty urinating, or signs of an allergic reaction.

Ipratropio Bromuro Cipla should not be used by individuals with known hypersensitivity to ipratropium bromide or any excipients, patients with narrow‑angle glaucoma, significant urinary retention, or those experiencing a severe COPD exacerbation that requires systemic therapy. Contraindications must be confirmed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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