Product image of Ipratropio Bromuro/Salbutamol Cipla (Salbutamol, Ipratropium Bromide Monohydrate) supplied by GNH India

Ipratropio Bromuro/Salbutamol Cipla

Active Ingredient:
Salbutamol, Ipratropium Bromide Monohydrate
Origin:
EU

Ipratropio Bromuro/Salbutamol Cipla (Salbutamol, Ipratropium Bromide Monohydrate)

Ipratropium bromide and salbutamol, the active ingredients in Ipratropio Bromuro/Salbutamol Cipla, are bronchodilators presented as an inhalation solution for inhalation use. It treats bronchospasm associated with chronic obstructive pulmonary disease (COPD) and acute asthma in adult patients.

GNH India supplies Ipratropio Bromuro/Salbutamol Cipla as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cipla Europe Nv

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Indications & Clinical Uses

Ipratropium bromide/salbutamol is indicated for conditions involving airway bronchoconstriction.

  • Chronic obstructive pulmonary disease (COPD): provides bronchodilation to relieve bronchospasm and improve airflow.
  • Acute asthma: rapidly relaxes airway smooth muscle to ease breathing during an asthma attack.
  • Bronchospasm associated with COPD: reduces airway resistance and helps maintain ventilation.

How It Works

  • Ipratropium bromide acts as a muscarinic antagonist, blocking acetylcholine‑mediated bronchoconstriction, while salbutamol is a short‑acting β2‑adrenergic agonist that stimulates β2 receptors on airway smooth muscle, increasing cyclic AMP and causing muscle relaxation. The combined action results in synergistic bronchodilation and improved airway patency.

Side Effects

The inhalation product may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Cough or throat irritation.
  • Dry mouth or hoarseness.
  • Tremor or shakiness.
  • Palpitations or increased heart rate.
  • Headache.
  • Nausea.

Serious or Rare Side Effects

  • Paradoxical bronchospasm.
  • Severe tachycardia or arrhythmia.
  • Hypokalemia.
  • Allergic reactions such as rash, angioedema, or anaphylaxis.
  • Elevated blood pressure.
  • Acute respiratory distress.

Precautions & Warnings

Before using this inhalation product, consider the following safety measures.

  • Contraindicated in patients with known hypersensitivity to either component.
  • Use with caution in individuals with cardiovascular disease, especially arrhythmias.
  • Monitor blood potassium levels in patients at risk of hypokalemia.
  • Assess for potential paradoxical bronchospasm, particularly after the first dose.
  • Avoid use in patients with severe narrow‑angle glaucoma.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Ipratropium bromide/salbutamol may interact with other medications, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Non‑selective β‑blockers: can diminish bronchodilator response and precipitate bronchospasm.
  • Monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants: may increase risk of cardiovascular side effects.

Moderate Interactions (Monitor Closely)

  • Diuretics or corticosteroids: may potentiate hypokalemia.
  • Other bronchodilators (e.g., long‑acting β2‑agonists): risk of additive tachycardia.
  • Anticholinergic drugs: may enhance anticholinergic effects such as dry mouth.
  • Theophylline: possible increase in theophylline serum levels.
  • Antihistamines: may increase anticholinergic burden.

Frequently Asked Questions

Ipratropio Bromuro/Salbutamol Cipla is prescribed to relieve bronchospasm in chronic obstructive pulmonary disease (COPD) and to provide rapid bronchodilation during acute asthma attacks. The combination targets airway narrowing by two complementary mechanisms, helping patients improve breathing and reduce symptoms.

Ipratropium bromide blocks muscarinic receptors, preventing acetylcholine‑induced bronchoconstriction, while salbutamol stimulates β2‑adrenergic receptors, increasing cyclic AMP and relaxing airway smooth muscle. Together they produce a synergistic bronchodilatory effect that opens the airways more effectively than either agent alone.

The prescribed dose of Ipratropio Bromuro/Salbutamol Cipla is determined by the treating physician based on the patient’s clinical condition, severity of bronchospasm, and response to therapy. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety data for ipratropium bromide and salbutamol during pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers should evaluate each case individually and discuss possible risks with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with single‑agent inhalers, the ipratropium/salbutamol combination offers dual mechanisms—anticholinergic and β2‑agonist—providing broader bronchodilation. This can result in faster symptom relief and improved lung function, especially in patients who do not respond adequately to monotherapy.

Store the inhalation product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct sunlight, and ensure the canister is tightly closed when not in use to maintain drug stability.

The medication is delivered via a metered‑dose inhaler or nebulizer, depending on the formulation supplied. The patient inhales the prescribed number of puffs or nebulized doses as instructed by the prescriber, typically using a spacer or face mask for optimal drug deposition in the lungs.

Serious adverse events include paradoxical bronchospasm, severe tachycardia or arrhythmia, significant hypokalemia, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden worsening of breathing, chest pain, rapid heartbeat, or signs of an allergic response.

Individuals with a known hypersensitivity to ipratropium bromide, salbutamol, or any excipients in the formulation should avoid this product. It is also contraindicated in patients with severe narrow‑angle glaucoma and should be used with caution in those with significant cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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