Product image of Ipratropium Bromide Accord Healthcare (Ipratropium Bromide) supplied by GNH India

Ipratropium Bromide Accord Healthcare

Active Ingredient:
Ipratropium Bromide
Origin:
EU

Ipratropium Bromide Accord Healthcare (Ipratropium Bromide)

Ipratropium bromide, the active ingredient in Ipratropium Bromide Accord Healthcare, is an anticholinergic bronchodilator presented as an inhalation solution for inhalation use. It is used to relieve bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD) and asthma.
GNH India supplies Ipratropium Bromide Accord Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Limited

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Indications & Clinical Uses

Ipratropium bromide is a bronchodilator that acts on the muscarinic receptors of the airway smooth muscle, helping to manage obstructive airway diseases.

  • Chronic obstructive pulmonary disease (COPD): improves airflow and reduces symptoms of breathlessness.
  • Asthma: provides additional bronchodilation as part of a maintenance regimen.
  • Exercise‑induced bronchospasm: can be used to prevent bronchoconstriction during physical activity.

How It Works

  • Ipratropium bromide competitively blocks muscarinic (M3) receptors on airway smooth muscle, inhibiting the action of acetylcholine. This prevents calcium‑mediated contraction, reduces bronchoconstriction, and promotes bronchodilation, thereby improving airflow in obstructive lung conditions.

Side Effects

Ipratropium bromide may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Dry mouth: reduced salivary secretion.
  • Cough: irritation of the airway.
  • Throat irritation: mild soreness after inhalation.
  • Hoarseness: temporary voice changes.
  • Headache: mild, transient.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Paradoxical bronchospasm: sudden worsening of breathing.
  • Allergic reaction: rash, itching, or angioedema.
  • Severe cough or chest tightness.
  • Respiratory distress: difficulty breathing.
  • Anaphylaxis: rare, life‑threatening hypersensitivity.
  • Acute urinary retention: especially in predisposed patients.

Precautions & Warnings

Before prescribing ipratropium bromide, clinicians should consider several safety aspects.

  • Assess respiratory status: evaluate severity of COPD or asthma before initiation.
  • Monitor for paradoxical bronchospasm: discontinue if symptoms worsen.
  • Avoid in patients with known hypersensitivity to ipratropium or atropine derivatives.
  • Use with caution in narrow‑angle glaucoma: anticholinergic effects may increase intra‑ocular pressure.
  • Use with caution in patients with urinary retention or prostatic hypertrophy.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Ipratropium bromide can interact with other medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent use with other anticholinergic agents: may increase anticholinergic side‑effects such as dry mouth and urinary retention.
  • Use with potent cholinergic antagonists: risk of additive bronchodilation leading to tachycardia.

Moderate Interactions (Monitor Closely)

  • Beta‑2 agonists (e.g., albuterol): monitor for additive bronchodilation and potential tachycardia.
  • Theophylline: may require serum level monitoring.
  • Antihistamines: increased anticholinergic load may enhance dry mouth.
  • Diuretics: watch for urinary retention in susceptible individuals.

Frequently Asked Questions

Ipratropium Bromide Accord Healthcare is an inhaled anticholinergic bronchodilator indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD) and for adjunctive therapy in asthma. It helps to open the airways by reducing bronchoconstriction, thereby improving breathing in patients with these obstructive lung conditions.

Ipratropium bromide works by competitively blocking muscarinic (M3) receptors on airway smooth muscle. This inhibition prevents acetylcholine‑mediated calcium influx, which reduces muscle contraction and bronchoconstriction. The resulting bronchodilation improves airflow and eases symptoms of breathlessness in COPD and asthma.

The dose of ipratropium bromide is individualized by the prescribing healthcare professional based on the patient’s condition, severity, and response to therapy. The prescriber determines the appropriate number of inhalations per day and the specific device to be used.

Safety data for ipratropium bromide in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers will assess each case and make an informed decision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Ipratropium bromide is an anticholinergic bronchodilator that provides longer‑lasting airway relaxation, especially useful in COPD. Albuterol is a short‑acting β2‑agonist that acts quickly to relieve acute bronchospasm. Clinicians often combine both agents to achieve complementary bronchodilation, with ipratropium offering a steadier effect and albuterol providing rapid relief.

The inhalation solution should be stored below 25 °C, in its original container, protected from moisture and direct light. Do not freeze the product. Keep the device out of reach of children and follow any additional handling instructions provided with the packaging.

The medication is delivered via a metered‑dose inhaler or nebulizer, as directed by the prescriber. Patients should inhale the prescribed number of puffs or nebulized doses, typically using a spacer or mouthpiece to ensure optimal deposition in the lungs. Proper inhalation technique should be reviewed with a healthcare professional.

The most serious risks include paradoxical bronchospasm, which can worsen breathing, and severe allergic reactions such as anaphylaxis. Patients should be monitored for sudden worsening of respiratory symptoms, rash, swelling, or difficulty breathing, and the medication should be discontinued immediately if these occur.

Ipratropium bromide is contraindicated in individuals with a known hypersensitivity to ipratropium, atropine, or any component of the formulation. Caution is also advised for patients with narrow‑angle glaucoma, urinary retention, or prostatic hypertrophy, as anticholinergic effects may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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