Product image of Ipratropium/Salbutamol Cipla (Salbutamol, Ipratropium Bromide Monohydrate) supplied by GNH India

Ipratropium/Salbutamol Cipla

Active Ingredient:
Salbutamol, Ipratropium Bromide Monohydrate
Origin:
EU

Ipratropium/Salbutamol Cipla (Salbutamol, Ipratropium Bromide Monohydrate)

Ipratropium bromide and Salbutamol, the active ingredients in Ipratropium/Salbutamol Cipla, are bronchodilators (anticholinergic + β2‑agonist) presented as an inhalation product for inhalation use. They are indicated for the relief of bronchospasm in obstructive airway diseases such as COPD and asthma.
GNH India supplies Ipratropium/Salbutamol Cipla as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cipla Europe Nv

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Indications & Clinical Uses

Ipratropium/Salbutamol Cipla is a combination bronchodilator used in obstructive airway diseases.

  • Chronic obstructive pulmonary disease (COPD): provides rapid relief of bronchospasm and improves airflow.
  • Asthma: reduces bronchoconstriction and helps control acute symptoms.
  • Acute bronchospasm: delivers quick bronchodilation to ease breathing difficulties.

How It Works

  • The combination works by two complementary mechanisms: ipratropium bromide antagonizes muscarinic receptors on airway smooth muscle, preventing acetylcholine‑mediated bronchoconstriction, while salbutamol stimulates β2‑adrenergic receptors, causing relaxation of bronchial smooth muscle. The dual action results in enhanced bronchodilation and improved airway patency.

Side Effects

Common Side Effects

  • Cough or throat irritation: mild discomfort during inhalation.
  • Tremor: transient shaking, often of the hands.
  • Headache: mild to moderate intensity.
  • Dry mouth: reduced salivation after use.

Serious or Rare Side Effects

  • Paradoxical bronchospasm: worsening of breathing difficulty.
  • Angioedema: swelling of face, lips, or tongue.
  • Tachyarrhythmia: rapid or irregular heart rhythm.
  • Severe allergic reaction: rash, itching, or anaphylaxis.

Precautions & Warnings

Before using Ipratropium/Salbutamol Cipla, consider the following precautions:

  • Cardiac history: monitor for tachyarrhythmias in patients with heart disease.
  • Hypersensitivity: avoid if known allergy to ipratropium, salbutamol, or formulation components.
  • Cardiovascular disease: use with caution in severe hypertension or coronary artery disease.
  • Dosage limits: do not exceed the prescribed frequency; follow healthcare provider instructions.
  • Pregnancy and lactation: discuss potential risks with a qualified professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ipratropium/Salbutamol Cipla may interact with other medicines as follows:

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator effectiveness.
  • MAO inhibitors: increased risk of severe bronchospasm.
  • Tricyclic antidepressants: can heighten cardiovascular side effects.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate hypokalemia; monitor electrolyte levels.
  • Theophylline: additive bronchodilator effect; observe for toxicity.
  • Other anticholinergics: increased anticholinergic load; watch for dry mouth and urinary retention.

Frequently Asked Questions

Ipratropium/Salbutamol Cipla is an inhaled combination bronchodilator indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease (COPD) and asthma. It helps open the airways, making breathing easier during acute episodes or as part of a maintenance regimen prescribed by a healthcare professional.

Ipratropium bromide blocks muscarinic receptors on airway smooth muscle, preventing acetylcholine‑induced constriction. Salbutamol activates β2‑adrenergic receptors, causing smooth‑muscle relaxation. The simultaneous inhibition of bronchoconstriction and promotion of bronchodilation produces a synergistic effect that improves airflow in obstructive airway conditions.

The dosage of Ipratropium/Salbutamol Cipla is determined by the prescribing clinician based on the patient’s age, disease severity, and response to therapy. The prescriber will specify the number of inhalations, frequency, and duration appropriate for each individual case.

Safety data for Ipratropium/Salbutamol Cipla during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Pregnant or nursing patients should discuss use with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the team will respond with pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with monotherapy agents such as salbutamol alone or ipratropium alone, the combination provides additive bronchodilation, often resulting in faster symptom relief and improved lung function. This dual mechanism can be advantageous for patients who require both rapid and sustained airway opening, reducing the need for multiple separate inhalers.

Store Ipratropium/Salbutamol Cipla at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use to maintain potency.

The product is delivered by inhalation, typically using a nebulizer or a metered‑dose inhaler as directed by the prescriber. The patient should inhale slowly and deeply, hold the breath for a few seconds if possible, and then exhale. Proper technique ensures optimal drug deposition in the lungs.

Serious adverse events include paradoxical bronchospasm (worsening of breathing difficulty), severe allergic reactions such as angioedema or anaphylaxis, and cardiac arrhythmias, especially in patients with underlying heart disease. Any sudden worsening of symptoms or signs of an allergic reaction should prompt immediate medical attention.

The medication should be avoided in individuals with known hypersensitivity to ipratropium, salbutamol, or any excipients in the formulation. Caution is also advised for patients with severe narrow‑angle glaucoma, uncontrolled cardiovascular disease, or those taking certain interacting medications without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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