Product image of Ipratropiumbromid/Salbutamol "neutec" (Ipratropium Bromide, Salbutamol) supplied by GNH India

Ipratropiumbromid/Salbutamol "neutec"

Active Ingredient:
Ipratropium Bromide, Salbutamol
Origin:
EU

Ipratropiumbromid/Salbutamol "neutec" (Ipratropium Bromide, Salbutamol)

Ipratropium bromide, the active ingredient in Ipratropiumbromid/Salbutamol \"neutec\", is a short‑acting muscarinic antagonist presented as an inhalation aerosol (metered‑dose inhaler) for inhalation use. Combined with salbutamol, a short‑acting β2‑agonist, the product provides bronchodilation for chronic obstructive pulmonary disease and rapid relief of asthma symptoms.

GNH India supplies Ipratropiumbromid/Salbutamol \"neutec\" as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU regulatory standards and is available for export to multiple regions, ensuring quality and consistency across shipments.

Manufacturer / TM Owner

Neutec Inhaler Ireland Ltd

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Indications & Clinical Uses

Ipratropium bromide/salbutamol inhalation aerosol is used to manage airway obstruction in chronic respiratory diseases.

  • Chronic obstructive pulmonary disease (COPD): improves lung function and reduces breathlessness during stable disease and exacerbations.
  • Asthma: delivers fast‑acting bronchodilation to relieve acute symptoms or exercise‑induced bronchospasm.
  • Acute bronchospasm: provides rapid airway opening when sudden constriction occurs.

How It Works

  • Ipratropium bromide competitively blocks muscarinic (M3) receptors on airway smooth muscle, preventing acetylcholine‑mediated bronchoconstriction. Salbutamol stimulates β2‑adrenergic receptors, increasing cyclic AMP and causing relaxation of airway smooth muscle. The combined antagonistic and agonistic actions produce additive bronchodilation, improving airflow in obstructive airway diseases.

Side Effects

The inhaler may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Throat irritation or dryness
  • Cough
  • Tremor of the hands or fingers
  • Headache
  • Palpitations
  • Dry mouth

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Significant tachycardia or arrhythmia
  • Angioedema or severe allergic reaction
  • Hyperglycaemia in susceptible individuals
  • Acute hypertension
  • Severe hypokalaemia

Precautions & Warnings

Use of this combination inhaler requires careful clinical assessment and monitoring.

  • Assess patient history: check for hypersensitivity to anticholinergics or β2‑agonists.
  • Monitor cardiovascular status: use cautiously in patients with tachyarrhythmias or coronary disease.
  • Avoid excessive dosing: follow prescriber instructions to prevent systemic anticholinergic or adrenergic effects.
  • Use with caution in patients with narrow‑angle glaucoma, urinary retention, or prostatic hypertrophy.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and heat, store in original container.

Avoid Interactions

Drug interactions may modify the therapeutic effect or increase adverse risk.

Major Interactions (Avoid)

  • Beta‑blockers: may blunt bronchodilator response.
  • Monoamine oxidase inhibitors: can increase cardiovascular stimulation.
  • Diuretics: may potentiate hypokalaemia when combined with salbutamol.

Moderate Interactions (Monitor Closely):\n- Theophylline: additive risk of tachycardia and tremor.

  • Inhaled corticosteroids: may enhance bronchodilator efficacy.
  • Other anticholinergic agents: additive anticholinergic load may increase dry mouth or urinary retention.

Frequently Asked Questions

Ipratropiumbromid/Salbutamol "neutec" is a prescription inhalation aerosol that combines a short‑acting muscarinic antagonist with a short‑acting β2‑agonist. It is indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD) and as a rescue bronchodilator for rapid relief of asthma symptoms.

Ipratropium bromide blocks muscarinic receptors on airway smooth muscle, preventing acetylcholine‑induced constriction. Salbutamol activates β2‑adrenergic receptors, increasing cyclic AMP and causing smooth‑muscle relaxation. The dual mechanism provides additive bronchodilation, improving airflow in obstructive airway conditions.

The prescribed dose of Ipratropiumbromid/Salbutamol "neutec" is determined by the treating clinician based on the patient’s disease severity, response, and overall treatment plan. Patients should follow the specific inhalation instructions provided by their healthcare professional.

Safety data for Ipratropiumbromid/Salbutamol "neutec" in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To request a supply, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

When used separately, ipratropium provides anticholinergic bronchodilation while salbutamol offers β2‑adrenergic stimulation. The combination inhaler delivers both mechanisms simultaneously, often achieving faster and more complete airway opening than either agent alone, especially in patients who need dual pathway relief.

Store the inhaler at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct heat, and ensure the canister is upright when not in use to maintain dose consistency.

The device is a metered‑dose inhaler (MDI). After shaking the canister, the patient exhales fully, places the mouthpiece in the mouth, and actuates a puff while inhaling slowly and deeply. The prescribed number of puffs is then repeated, followed by a breath hold of a few seconds.

Serious adverse events include paradoxical bronchospasm, significant tachycardia or arrhythmia, angioedema, and severe hypertension. If any of these occur, the inhaler should be discontinued immediately and medical attention sought.

Patients with known hypersensitivity to ipratropium bromide, salbutamol, or any excipients in the formulation should avoid this product. Caution is also advised for individuals with narrow‑angle glaucoma, severe urinary retention, or uncontrolled cardiac arrhythmias, and the decision should be guided by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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