Product image of Ipratropiumbromide 40 Cyclocaps Teva (Ipratropium Bromide) supplied by GNH India

Ipratropiumbromide 40 Cyclocaps Teva

Active Ingredient:
Ipratropium Bromide
Origin:
EU

Ipratropiumbromide 40 Cyclocaps Teva (Ipratropium Bromide)

Ipratropium bromide, the active ingredient in Ipratropiumbromide 40 Cyclocaps Teva, is an anticholinergic (muscarinic antagonist) presented as a 40 µg cyclocaps for inhalation use. It treats chronic obstructive pulmonary disease, asthma (as add‑on therapy) and nasal congestion by relaxing airway smooth muscle and reducing secretions.

GNH India supplies Ipratropiumbromide 40 Cyclocaps Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Ipratropium bromide is an anticholinergic bronchodilator used in respiratory and nasal conditions.

  • Chronic obstructive pulmonary disease (COPD): improves airflow and reduces exacerbations.
  • Asthma (add‑on therapy): provides additional bronchodilation when combined with other agents.
  • Nasal congestion: decreases nasal secretions and eases blockage.
  • Rhinorrhea: reduces watery nasal discharge associated with allergic or non‑allergic rhinitis.

How It Works

  • Ipratropium bromide competitively blocks muscarinic (M1, M2, M3) acetylcholine receptors on airway smooth muscle and submucosal glands. This inhibition prevents intracellular calcium rise, leading to relaxation of bronchial smooth muscle and suppression of glandular secretions, thereby producing bronchodilation and reducing nasal secretions.

Side Effects

Ipratropium bromide may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Dry mouth: sensation of oral dryness.
  • Cough: transient irritation of the airway.
  • Throat irritation: mild soreness after inhalation.
  • Nasal irritation: burning or stinging in the nose.
  • Headache: mild to moderate intensity.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Urinary retention: difficulty emptying the bladder.
  • Glaucoma exacerbation: increased intra‑ocular pressure.
  • Paradoxical bronchospasm: worsening of breathing difficulty.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Angioedema: swelling of lips, tongue or face.
  • Tachycardia: rapid heart rate in susceptible individuals.

Precautions & Warnings

Before prescribing ipratropium bromide, consider patient‑specific factors and monitor for potential complications.

  • Renal impairment: dose may need adjustment in severe renal dysfunction.
  • Glaucoma: avoid in patients with narrow‑angle glaucoma due to anticholinergic effect.
  • Urinary retention: monitor patients with prostatic hypertrophy.
  • Pregnancy: safety category unknown; use only if benefit outweighs risk.
  • Elderly: increased sensitivity to anticholinergic effects; monitor closely.
  • Store at ambient temperature: keep capsules in the original container, protect from moisture and heat.

Avoid Interactions

Ipratropium bromide can interact with other medications that affect the cholinergic system or bronchodilation.

Major Interactions (Avoid)

  • Other anticholinergic agents (e.g., tiotropium, atropine): additive anticholinergic burden.
  • Antihistamines with anticholinergic properties: increased dryness and urinary retention.
  • Potent CYP inhibitors: may alter metabolism of concomitant drugs.

Moderate Interactions (Monitor Closely)

  • Beta‑agonists (e.g., albuterol): additive bronchodilation may cause tachycardia.
  • Diuretics: may exacerbate dry mouth.
  • MAO inhibitors: monitor for hypertensive episodes.

Frequently Asked Questions

Ipratropiumbromide 40 Cyclocaps Teva contains ipratropium bromide, an anticholinergic bronchodilator indicated for chronic obstructive pulmonary disease (COPD), as an add‑on therapy for asthma, and for relief of nasal congestion and rhinorrhea associated with allergic or non‑allergic rhinitis.

Ipratropium bromide blocks muscarinic acetylcholine receptors (M1, M2, M3) on airway smooth muscle and submucosal glands. By preventing acetylcholine binding, it reduces intracellular calcium, leading to relaxation of bronchial smooth muscle and inhibition of glandular secretions, which produces bronchodilation and decreases nasal mucus production.

The prescribed dose of Ipratropiumbromide 40 µg Cyclocaps is determined by the treating physician based on the individual’s condition, severity, and response to therapy. Patients should follow the dosing instructions provided on the prescription label and by their healthcare professional.

The pregnancy safety category for ipratropium bromide is unknown. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Limited data are available for breastfeeding; mothers should discuss potential risks and benefits with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ipratropium bromide is an anticholinergic bronchodilator, differing from β2‑agonists such as albuterol, which stimulate β2‑adrenergic receptors. It provides a complementary mechanism of action, often used as add‑on therapy to improve lung function when β2‑agonists alone are insufficient, and has a lower risk of tachycardia.

Store the cyclocaps at ambient temperature, below 25 °C, in the original packaging. Keep the capsules away from moisture, direct sunlight and excessive heat to maintain product stability and potency.

The capsules are intended for inhalation using a compatible dry‑powder inhaler device. The patient inhales the powdered medication deeply into the lungs or through the nasal route as directed by the prescriber, following the inhaler’s specific technique instructions.

Serious adverse events, although rare, include urinary retention, exacerbation of narrow‑angle glaucoma, paradoxical bronchospasm, severe allergic reactions such as anaphylaxis, and angioedema. Patients should seek immediate medical attention if they experience symptoms such as difficulty urinating, eye pain, worsening breathing, swelling of the face or throat, or rash.

Ipratropium bromide is contraindicated in patients with a known hypersensitivity to ipratropium bromide or any of the capsule excipients. Caution is advised in individuals with severe urinary retention, uncontrolled narrow‑angle glaucoma, or those who have experienced paradoxical bronchospasm with anticholinergic therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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