Product image of Ipren (Ibuprofen) supplied by GNH India

Ipren

Active Ingredient:
Ibuprofen
Origin:
EU

Ipren (Ibuprofen)

Ibuprofen, the active ingredient in Ipren, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a rectal dosage form for rectal use. It provides pain relief, reduces fever, and alleviates inflammation in adults and children when appropriate.

GNH India supplies Ipren as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mcneil Sweden Ab

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Indications & Clinical Uses

  • Ipren (ibuprofen) acts on the cyclooxygenase pathway to manage several common conditions.
  • Pain: reduces mild to moderate pain such as headache, dental or musculoskeletal discomfort.
  • Fever: lowers elevated body temperature associated with infections or inflammatory states.
  • Inflammation: decreases swelling and tenderness in conditions like arthritis or soft‑tissue injury.

How It Works

  • Ibuprofen inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis leads to diminished inflammation, analgesia, and antipyresis by limiting the mediators that sensitize nerve endings and regulate body temperature.

Side Effects

Adverse reactions may range from mild to severe and should be monitored.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia
  • Nausea or vomiting
  • Headache
  • Dizziness
  • Mild skin rash
  • Elevated blood pressure

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation
  • Acute renal impairment or failure
  • Severe allergic reactions such as anaphylaxis
  • Hepatic injury or elevated liver enzymes
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Cardiovascular events like myocardial infarction or stroke

Precautions & Warnings

  • Before using Ipren, consider the following safety measures.
  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
  • Evaluate renal function: avoid use in severe renal impairment.
  • Use lowest effective dose: limit duration to the shortest necessary period.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Caution with anticoagulants: monitor for increased bleeding risk.
  • Store at room temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Ibuprofen can interact with several medicines; awareness helps prevent complications.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened risk of ulceration.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: possible reduction in renal function.

  • Lithium: increased lithium serum levels.
  • Methotrexate: reduced clearance leading to toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding tendency.
  • Diuretics: potential for reduced renal perfusion.

Frequently Asked Questions

Ipren contains ibuprofen, an NSAID that is commonly used to relieve mild to moderate pain, lower fever, and reduce inflammation. It is appropriate for conditions such as headaches, dental pain, musculoskeletal aches, fever associated with infections, and inflammatory disorders like arthritis when administered via the rectal route.

Ibuprofen works by blocking the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. Prostaglandins promote inflammation, pain signaling, and fever. By reducing their synthesis, ibuprofen lessens these symptoms, providing analgesic, antipyretic, and anti‑inflammatory effects.

The specific dose of Ipren is determined by a qualified healthcare professional based on the patient’s age, weight, condition being treated, and overall health status. Prescribers set the appropriate amount and frequency to achieve therapeutic benefit while minimizing risk.

Safety of ibuprofen during pregnancy and lactation depends on the trimester and individual risk factors. Generally, ibuprofen is avoided in the third trimester and used with caution earlier in pregnancy. Breastfeeding mothers should consult a healthcare provider, as ibuprofen does pass into milk in small amounts.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Both ibuprofen (Ipren) and naproxen belong to the NSAID class and share similar mechanisms of COX inhibition. Ibuprofen generally has a shorter half‑life, requiring more frequent dosing, while naproxen has a longer duration of action. Choice between them depends on the clinical scenario, dosing convenience, and individual tolerance.

Ipren should be stored at room temperature, below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ipren is supplied as a rectal formulation, typically a suppository. The suppository is inserted gently into the rectum, where it dissolves and releases ibuprofen for systemic absorption. Administration should follow the instructions provided by a healthcare professional.

The most serious adverse events include gastrointestinal bleeding or ulcer perforation, acute kidney injury, severe allergic reactions such as anaphylaxis, and cardiovascular events like heart attack or stroke. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, blood in stool, sudden loss of kidney function, or signs of an allergic reaction.

Ipren should not be used by individuals with a known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulcers, severe renal or hepatic impairment, and patients in the third trimester of pregnancy. Caution is also advised for patients on anticoagulant therapy or with uncontrolled hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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