Product image of Ipsoflog (Piroxicam) supplied by GNH India

Ipsoflog

Active Ingredient:
Piroxicam
Origin:
EU

Ipsoflog (Piroxicam)

Piroxicam, the active ingredient in Ipsoflog, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular use. It treats rheumatoid arthritis, osteoarthritis, musculoskeletal pain and other inflammatory conditions in adult patients. It is indicated for the management of inflammatory and painful musculoskeletal disorders, providing symptomatic relief and reducing swelling.

GNH India supplies Ipsoflog as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to European Union quality standards and is manufactured under strict Good Manufacturing Practice (GMP) conditions.

Manufacturer / TM Owner

Tecnopharma S.R.L.

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Indications & Clinical Uses

Piroxicam is an NSAID that reduces inflammation by inhibiting cyclooxygenase enzymes, and it is used for several musculoskeletal and joint disorders.

  • Rheumatoid arthritis: alleviates joint pain, swelling and stiffness in chronic inflammatory disease.
  • Osteoarthritis: reduces pain and improves joint function in degenerative joint disease.
  • Musculoskeletal pain: provides rapid relief of acute pain from injuries or overuse.
  • Inflammatory conditions: diminishes inflammation in soft‑tissue disorders such as bursitis or tendinitis.

How It Works

  • Piroxicam exerts its anti‑inflammatory and analgesic actions by non‑selectively inhibiting cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, which decreases the synthesis of prostaglandins and thromboxanes. The reduced prostaglandin levels lower vascular permeability, edema, and pain signalling in inflamed tissues, while also limiting platelet aggregation. Additionally, piroxicam may modulate leukocyte adhesion and cytokine release, contributing further to its anti‑inflammatory profile. These combined effects result in decreased inflammation and pain at the site of injury or disease.

Side Effects

Piroxicam may be associated with a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate headache.
  • Dizziness: transient vertigo or light‑headedness.
  • Injection site reactions: pain, erythema or swelling at the intramuscular site.

Serious or Rare Side Effects

  • Severe gastrointestinal ulceration or bleeding.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

When using piroxicam injectable, clinicians should consider several precautionary measures to minimize risks.

  • Assess renal function: evaluate kidney status before initiating therapy.
  • Monitor hepatic function: check liver enzymes periodically during treatment.
  • Use lowest effective dose: limit exposure to reduce gastrointestinal and cardiovascular risk.
  • Avoid in patients with active peptic ulcer disease: contraindicated due to ulcer risk.
  • Caution in elderly patients: increased susceptibility to adverse effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Piroxicam can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • ACE inhibitors or diuretics: may reduce renal function.

Moderate Interactions (Monitor Closely)

  • Lithium: piroxicam may raise lithium levels.
  • Methotrexate: possible increased toxicity.
  • Cyclosporine: enhanced nephrotoxic effect.

Frequently Asked Questions

Ipsoflog contains piroxicam, an NSAID indicated for the treatment of rheumatoid arthritis, osteoarthritis, musculoskeletal pain and other inflammatory conditions. It helps reduce pain, swelling and stiffness associated with these disorders, providing symptomatic relief for adult patients.

Piroxicam works by non‑selectively inhibiting the cyclo‑oxygenase enzymes COX‑1 and COX‑2, which reduces the production of prostaglandins that mediate inflammation, pain and fever. Lower prostaglandin levels lead to decreased vascular permeability, edema and pain signalling in affected tissues.

The specific dose of Ipsoflog is determined by the prescribing clinician based on the patient’s condition, severity, age, renal and hepatic function, and other individual factors. Healthcare professionals set the appropriate dosage and frequency according to current clinical guidelines.

Safety data for piroxicam in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk, and a healthcare provider should be consulted before use in pregnant or nursing women.

To order Ipsoflog, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including cold‑chain if required) and any necessary import documentation.

Ipsoflog (piroxicam) has a relatively long half‑life compared with many NSAIDs such as ibuprofen or diclofenac, allowing once‑daily dosing in some formulations. Its anti‑inflammatory potency is comparable, but the risk profile for gastrointestinal and cardiovascular events is similar to other non‑selective NSAIDs, requiring the same precautionary measures.

Ipsoflog should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging to maintain stability and prevent contamination. If refrigeration is unavailable, consult the supplier for alternative storage guidance.

Ipsoflog is supplied as an injectable solution for intramuscular injection. A qualified healthcare professional administers the dose into a suitable muscle, typically the gluteal or deltoid region, using aseptic technique. The injection site should be monitored for pain, redness or swelling after administration.

The most serious risks include severe gastrointestinal ulceration or bleeding, hepatotoxicity manifested by elevated liver enzymes or hepatitis, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should be instructed to seek immediate medical attention if they experience signs of these conditions.

Ipsoflog should be avoided in patients with known hypersensitivity to piroxicam or other NSAIDs, active peptic ulcer disease, severe hepatic or renal impairment, and in those receiving anticoagulant therapy where bleeding risk is high. Caution is also advised for the elderly and for individuals with cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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