Product image of Ipsoflog (Piroxicam) supplied by GNH India

Ipsoflog

Active Ingredient:
Piroxicam
Origin:
EU

Ipsoflog (Piroxicam)

Piroxicam, the active ingredient in Ipsoflog, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It is commonly employed to relieve pain and inflammation associated with rheumatic disorders and acute musculoskeletal conditions throughout the body in adult patients.

GNH India supplies Ipsoflog as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with capabilities to meet bulk and custom order requirements, and to provide comprehensive documentation for import and distribution across EU, Asia and Africa.

Manufacturer / TM Owner

Tecnopharma S.R.L.

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Indications & Clinical Uses

  • Piroxicam is indicated for several inflammatory and musculoskeletal conditions where it reduces pain and swelling.
  • Rheumatoid arthritis: reduces joint pain, swelling and stiffness in adult patients.
  • Osteoarthritis: alleviates chronic joint discomfort and improves mobility.
  • Ankylosing spondylitis: diminishes spinal inflammation and associated pain.
  • Acute pain and inflammation: provides rapid relief of short‑term musculoskeletal pain and inflammatory swelling.

How It Works

  • Piroxicam exerts its therapeutic effect by non‑selectively inhibiting cyclooxygenase enzymes COX‑1 and COX‑2, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, pain signalling and fever generation in affected tissues. By limiting prostaglandin‑mediated vasodilation and leukocyte infiltration, piroxicam also stabilizes cell membranes and diminishes the sensitization of nociceptors, contributing to its analgesic and antipyretic properties.

Side Effects

Piroxicam may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo: transient episodes.
  • Skin rash: mild erythema or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding: potentially life‑threatening hemorrhage.
  • Hepatic injury: elevated liver enzymes or hepatitis.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before prescribing piroxicam, clinicians should evaluate patient risk factors and monitor for potential complications.

  • Assess renal function: monitor serum creatinine and adjust use in renal impairment.
  • Evaluate hepatic status: avoid in patients with active liver disease.
  • Review gastrointestinal history: contraindicated in active peptic ulcer disease.
  • Use caution in elderly: increased susceptibility to adverse effects.
  • Avoid concurrent anticoagulants: heightened bleeding risk unless clinically justified.
  • Store at room temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Piroxicam can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • Corticosteroids: heightened ulceration risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible reduction in renal function.
  • Diuretics: may exacerbate renal impairment.
  • Lithium: piroxicam can raise lithium serum concentrations.

Frequently Asked Questions

Ipsoflog contains piroxicam, an NSAID that is prescribed to manage pain and inflammation in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and short‑term acute musculoskeletal pain. It helps reduce swelling, stiffness and discomfort associated with these inflammatory disorders.

Piroxicam works by non‑selectively blocking the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it diminishes inflammation, pain signaling, and fever responses in the affected tissues.

The specific dose of Ipsoflog is determined by the prescribing healthcare professional based on the patient’s condition, severity, age, renal and hepatic function, and other individual factors. Patients should follow the exact regimen provided by their prescriber and not adjust the dose on their own.

The safety of piroxicam in pregnancy and lactation has not been definitively established, and it is generally classified as contraindicated or used only when the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To request Ipsoflog, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ipsoflog (piroxicam) has a relatively long half‑life, allowing once‑daily dosing in many cases, which can be convenient compared with shorter‑acting NSAIDs such as ibuprofen. However, its gastrointestinal and renal risk profile is similar to other non‑selective NSAIDs, so risk‑benefit assessment remains essential.

Ipsoflog should be stored at room temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, direct sunlight and excessive heat to maintain stability and potency throughout the shelf life.

Ipsoflog is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with meals may reduce mild gastrointestinal discomfort. Patients should swallow the tablet whole and not crush or chew it unless instructed otherwise.

The most serious adverse events linked to piroxicam include gastrointestinal ulceration or bleeding, severe hepatic injury, renal impairment, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if any signs of these conditions appear.

Ipsoflog is contraindicated in patients with known hypersensitivity to piroxicam or other NSAIDs, active peptic ulcer disease, severe hepatic or renal impairment, and those on anticoagulant therapy where bleeding risk is unacceptable. It should also be avoided in the third trimester of pregnancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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