Product image of Ipstyl Autogel (Lanreotide) supplied by GNH India

Ipstyl Autogel

Active Ingredient:
Lanreotide
Origin:
EU

Ipstyl Autogel (Lanreotide)

Lanreotide, the active ingredient in Ipstyl Autogel, is a somatostatin analog presented as a long‑acting injectable for subcutaneous use. It treats acromegaly and hormone‑secreting neuroendocrine tumors in adult patients.

GNH India supplies Ipstyl Autogel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Institut Produits Synthèse (Ipsen) Ab

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Indications & Clinical Uses

  • Lanreotide is used to manage conditions driven by excess growth hormone or hormone secretion from neuroendocrine tumors.
  • Acromegaly: reduces serum IGF‑1 levels and controls tumor growth.
  • Neuroendocrine tumors (carcinoid syndrome): alleviates flushing, diarrhea and other hormone‑related symptoms.
  • Post‑surgical residual disease in acromegaly: maintains long‑term hormonal control.

How It Works

  • Lanreotide is a synthetic analogue of somatostatin that binds with high affinity to somatostatin receptors, primarily SSTR2 and SSTR5. Receptor activation inhibits adenylate cyclase activity, reduces cyclic AMP formation, and suppresses secretion of growth hormone, insulin, glucagon and various peptide hormones, thereby controlling hormone‑driven disease processes.

Side Effects

Lanreotide may cause a range of adverse reactions, most of which are mild to moderate in severity.

Common Side Effects

  • Injection site pain or erythema
  • Nausea or vomiting
  • Diarrhea or abdominal cramps
  • Headache
  • Hyperglycemia or altered glucose tolerance
  • Fatigue

Serious or Rare Side Effects

  • Gallstone formation or biliary colic
  • Acute pancreatitis
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Cardiac arrhythmias
  • Severe hyperglycemia leading to ketoacidosis
  • Pituitary apoplexy (rare)

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor for known safety concerns.
  • Monitor glucose: patients with diabetes may experience worsening glycemic control.
  • Assess gallbladder: risk of gallstone development warrants periodic imaging.
  • Screen for hypersensitivity: avoid use in individuals with known allergy to lanreotide or formulation excipients.
  • Pregnancy: prescribe only when potential benefit justifies potential risk to the fetus.
  • Renal or hepatic impairment: consider closer monitoring and possible dose adjustment.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide can interact with other medications that affect hormone levels or metabolic pathways.

Major Interactions (Avoid)

  • Co‑administration with other somatostatin analogues (e.g., octreotide) may amplify hormonal suppression and hyperglycemia.
  • Concomitant cyclosporine can increase lanreotide plasma concentrations.
  • Use with investigational agents that target the same receptors should be avoided.

Moderate Interactions (Monitor Closely)

  • Antidiabetic drugs (insulin, sulfonylureas) may require dose adjustments due to altered glucose homeostasis.
  • Warfarin: potential effect on coagulation parameters warrants INR monitoring.
  • Oral contraceptives: somatostatin analogues may reduce steroid hormone levels, affecting efficacy.
  • Antifungal azoles (e.g., ketoconazole) may modify lanreotide metabolism.
  • Beta‑blockers: monitor for additive effects on heart rate and blood pressure.

Frequently Asked Questions

Ipstyl Autogel, containing lanreotide, is indicated for the management of acromegaly and for control of hormone‑related symptoms in patients with neuroendocrine tumors, such as carcinoid syndrome. It helps lower excess growth hormone and other peptide hormones that drive these diseases.

Lanreotide mimics the natural hormone somatostatin and binds to somatostatin receptors, especially SSTR2 and SSTR5, on target cells. This binding inhibits adenylate cyclase, reduces cyclic AMP, and suppresses the secretion of growth hormone, insulin, glucagon, and other peptide hormones, thereby controlling disease activity.

The specific dose and dosing interval of Ipstyl Autogel are determined by the prescribing clinician based on the patient’s condition, disease severity, and response to therapy. Healthcare professionals tailor the regimen to achieve optimal hormonal control while minimizing adverse effects.

Safety data for lanreotide in pregnancy and lactation are limited. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The sales team then replies with pricing, availability, shipping details (including cold‑chain handling if needed) and any required import documentation.

Ipstyl Autogel (lanreotide) and other long‑acting somatostatin analogues such as octreotide LAR share a similar mechanism of receptor binding and clinical indications. Differences lie in dosing frequency, formulation stability, and individual patient tolerability. Choice of therapy is guided by physician assessment of efficacy, convenience, and safety profile for each patient.

Ipstyl Autogel should be stored at 2‑8 °C (refrigerated). Keep the product in its original container, protect it from light, and avoid freezing or shaking the vial. Do not store at room temperature for extended periods, as this may affect product stability.

Ipstyl Autogel is given as a subcutaneous injection by a qualified healthcare professional. The formulation is a pre‑filled autoinjector or vial designed for deep subcutaneous delivery, typically administered in the abdomen, thigh or upper arm according to the prescriber’s instructions.

Serious risks include gallstone formation, acute pancreatitis, severe hyperglycemia that can lead to diabetic ketoacidosis, and rare allergic reactions such as anaphylaxis. Patients should be monitored for signs of abdominal pain, jaundice, sudden changes in blood glucose, or any hypersensitivity symptoms.

Ipstyl Autogel is contraindicated in individuals with known hypersensitivity to lanreotide or any component of the formulation. Caution is advised for patients with uncontrolled diabetes, active gallbladder disease, severe hepatic or renal impairment, and pregnant or nursing women unless the benefit justifies the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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