Product image of Ipv-Boostrix (Aluminium Phosphate, Diphtheria Toxoid Adsorbed On Aluminium Hydroxide, Hydrated And Aluminium Phosp) supplied by GNH India

Ipv-Boostrix

Active Ingredient:
Aluminium Phosphate, Diphtheria Toxoid Adsorbed On Aluminium Hydroxide, Hydrated And Aluminium Phosp
Origin:
EU

Ipv-Boostrix (Aluminium Phosphate, Diphtheria Toxoid Adsorbed On Aluminium Hydroxide, Hydrated And Aluminium Phosp)

Aluminium Phosphate, Diphtheria Toxoid Adsorbed On Aluminium Hydroxide, the active ingredient in Ipv-Boostrix, is a vaccine presented as an injectable vaccine for intramuscular use. The formulation contains aluminium salts as adjuvants to boost immune response and protects against diphtheria, tetanus, pertussis and poliomyelitis in children and adults.

GNH India supplies Ipv-Boostrix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution aligned to EU regulatory standards.

Manufacturer / TM Owner

Glaxosmithkline (Ireland) Limited

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Indications & Clinical Uses

Ipv-Boostrix is used in immunization programs targeting bacterial and viral diseases that affect the respiratory and nervous systems.

  • Diphtheria: induces protective antibodies against diphtheria toxin, preventing disease.
  • Tetanus: stimulates immunity to tetanus toxin, reducing risk of tetanus infection.
  • Pertussis: generates antibodies that limit Bordetella pertussis colonisation and cough severity.
  • Poliomyelitis: elicits neutralising antibodies that block poliovirus replication and paralysis.

How It Works

  • Ipv-Boostrix contains diphtheria toxoid and other antigens adsorbed onto aluminium phosphate/hydroxide particles. The aluminium salts act as adjuvants, enhancing antigen presentation and stimulating dendritic cells. This provokes a robust humoral and cellular immune response, leading to the production of specific antibodies that neutralise diphtheria toxin, tetanus toxin, pertussis bacteria and poliovirus, thereby conferring active immunity.

Side Effects

Ipv-Boostrix may cause a range of post‑vaccination reactions, most of which are mild and self‑limiting.

Common Side Effects

  • Injection site pain: soreness at the injection site.
  • Redness or swelling: localized erythema or edema.
  • Low‑grade fever: mild temperature rise within 24‑48 hours.
  • Headache: transient headache after vaccination.
  • Fatigue: temporary tiredness or malaise.
  • Muscle aches: mild myalgia around the injection area.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: rare neurologic events post‑vaccination.
  • Guillain‑Barré syndrome: extremely rare autoimmune neuropathy.
  • Severe allergic reaction: urticaria, angioedema, or bronchospasm.
  • High‑grade fever: persistent fever above 39 °C.
  • Thrombocytopenia: rare drop in platelet count.

Precautions & Warnings

Before administering Ipv-Boostrix, healthcare professionals should observe the following precautions.

  • Allergy screening: avoid use in individuals with known hypersensitivity to any vaccine component.
  • Acute illness: postpone vaccination if the patient has a moderate or severe febrile illness.
  • Immunocompromised status: consult a specialist before vaccinating patients with weakened immune systems.
  • Post‑injection monitoring: observe the recipient for at least 15 minutes for immediate adverse reactions.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ipv-Boostrix can interact with certain medical products that may alter its immunogenicity or safety profile.

Major Interactions (Avoid)

  • Immunoglobulin therapy: may diminish vaccine efficacy; avoid simultaneous administration.
  • Blood products (e.g., plasma): can interfere with immune response; schedule at least 24 hours apart.

Moderate Interactions (Monitor Closely)

  • Other inactivated vaccines given at the same visit: monitor for additive local reactions.
  • Antipyretics (acetaminophen, ibuprofen): may mask fever; assess symptom severity.
  • Systemic corticosteroids: may reduce antibody production; consider timing of dose.
  • Live vaccines administered within 4 weeks: monitor for potential immune interference.

Frequently Asked Questions

Ipv-Boostrix is a combination vaccine indicated for active immunisation against diphtheria, tetanus, pertussis (whooping cough) and poliomyelitis. It is administered to children and adults as part of routine or catch‑up vaccination schedules to provide protection from these potentially serious infectious diseases.

Aluminium phosphate acts as an adjuvant in Ipv-Boostrix. It binds the vaccine antigens and creates a depot at the injection site, enhancing antigen uptake by immune cells. This promotes a stronger and longer‑lasting antibody response, improving the overall effectiveness of the vaccine.

The dose and schedule of Ipv-Boostrix are determined by the prescribing clinician based on age, immunisation history and local guidelines. Typically, a single intramuscular injection is given, with additional doses recommended according to national immunisation programmes.

Safety data for Ipv-Boostrix in pregnancy are limited, and the vaccine is generally administered only when the benefits outweigh potential risks. Breastfeeding is not a contraindication, but mothers should discuss vaccination with their healthcare provider to assess individual circumstances.

To order Ipv-Boostrix, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Ipv-Boostrix contains the same core antigens as other DTP‑IPV combination vaccines but uses aluminium phosphate as its adjuvant, which may influence reactogenicity and immune response. Comparative clinical data suggest similar efficacy, while the safety profile may differ slightly in terms of local injection‑site reactions.

Ipv-Boostrix must be stored in a refrigerated environment between 2 °C and 8 °C. It should be kept in the original packaging, protected from light, and must never be frozen or shaken. Maintaining the cold chain is essential to preserve vaccine potency.

Ipv-Boostrix is given as a single intramuscular injection, usually into the deltoid muscle of adults or the anterolateral thigh of infants and young children. The injection should be performed by a qualified healthcare professional using aseptic technique.

The most serious adverse events associated with Ipv-Boostrix are severe allergic reactions such as anaphylaxis, which require immediate medical attention. Rare neurological complications like Guillain‑Barré syndrome have also been reported. Recipients should be observed for at least 15 minutes post‑injection.

Ipv-Boostrix is contraindicated in individuals with a known severe allergy to any vaccine component, including aluminium salts. It should also be avoided in persons who have experienced a previous severe reaction to a diphtheria‑tetanus‑pertussis‑polio vaccine. Clinical judgment is required for immunocompromised patients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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