Product image of Irabel (Irbesartan) supplied by GNH India

Irabel

Active Ingredient:
Irbesartan
Origin:
EU

Irabel (Irbesartan)

Irbesartan, the active ingredient in Irabel, is an angiotensin II receptor blocker presented as an oral tablet for oral use. It is used to lower blood pressure and protect kidney function in patients with hypertension, diabetic nephropathy, or heart failure.

GNH India supplies Irabel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Clients benefit from consistent batch release, comprehensive documentation, and responsive technical support.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Irabel (irbesartan) acts on the renin‑angiotensin‑aldosterone system to manage several cardiovascular and renal conditions.

  • Hypertension: Reduces systolic and diastolic blood pressure, decreasing risk of stroke and heart attack.
  • Diabetic nephropathy: Slows progression of kidney damage in patients with type 2 diabetes.
  • Heart failure: Improves symptoms and reduces hospitalisation in patients with chronic heart failure.
  • Left ventricular hypertrophy: Contributes to regression of cardiac remodeling in hypertensive patients.

How It Works

  • Irbesartan selectively blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from binding and activating the receptor. This inhibition reduces vasoconstriction, aldosterone secretion, and sympathetic activation, leading to vasodilation, decreased sodium and water retention, and lower systemic vascular resistance. The net effect is a reduction in blood pressure and attenuation of pathological cardiac and renal remodeling.

Side Effects

Irabel may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Cough
  • Hyperkalaemia
  • Increased serum creatinine

Serious or Rare Side Effects

  • Angioedema
  • Severe hypotension
  • Acute renal failure
  • Hepatic injury
  • Neutropenia
  • Anaphylactoid reaction

Precautions & Warnings

Before initiating Irabel, several safety considerations should be observed.

  • Blood pressure monitoring: Check regularly to avoid excessive hypotension.
  • Renal function assessment: Evaluate serum creatinine and eGFR before initiation and during therapy.
  • Electrolyte surveillance: Monitor potassium levels, especially in patients with renal impairment or on potassium‑sparing agents.
  • Pregnancy consideration: Use only if potential benefit justifies risk; avoid in second and third trimester.
  • Drug discontinuation: Do not stop abruptly in patients with heart failure; taper under medical supervision.
  • Store at ambient temperature: Keep below 25 °C, in original container, protected from moisture and light.

Avoid Interactions

Irabel can interact with several medicines; awareness of the interaction level helps guide clinical decisions.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or supplements: May cause dangerous hyperkalaemia.
  • Aliskiren in diabetic patients: Increases risk of renal impairment and hyperkalaemia.
  • Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): Can raise irbesartan plasma levels.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or other ARBs: Additive blood pressure lowering, risk of hypotension.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): May reduce antihypertensive effect and impair renal function.
  • Lithium: May increase lithium levels, requiring monitoring.

Frequently Asked Questions

Irabel contains irbesartan, an angiotensin II receptor blocker indicated for the treatment of hypertension, diabetic nephropathy and chronic heart failure. By lowering blood pressure and reducing renal stress, it helps prevent cardiovascular events and slows kidney disease progression in eligible patients.

Irbesartan selectively blocks the AT1 subtype of the angiotensin II receptor. This prevents angiotensin II‑mediated vasoconstriction, aldosterone release, and sympathetic activation, resulting in vasodilation, reduced sodium and water retention, and ultimately lower systemic blood pressure.

The appropriate dose of Irabel is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and renal function. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Safety data for irbesartan in pregnancy are limited, and the drug is generally avoided in the second and third trimesters because of potential fetal harm. Breastfeeding mothers should consult their healthcare provider, as irbesartan may be excreted in breast milk.

To order Irabel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irabel belongs to the ARB class, offering similar blood‑pressure‑lowering efficacy to ACE inhibitors but with a lower incidence of cough and angioedema. Compared with other ARBs, irbesartan has a long half‑life and is often chosen for its renal‑protective profile in diabetic patients.

Irabel tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Irabel is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious adverse events include angioedema, severe hypotension, acute renal failure, and significant hyperkalaemia. Patients should seek immediate medical attention if they experience swelling of the face or throat, dizziness, rapid loss of blood pressure, or marked changes in kidney function.

Irabel is contraindicated in patients with known hypersensitivity to irbesartan or any component of the formulation, and in those with severe hepatic impairment. Caution is advised for individuals with bilateral renal artery stenosis, pregnant women in later trimesters, and patients on concurrent potassium‑raising therapies.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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