Product image of Irbesartán Almus (Irbesartan) supplied by GNH India

Irbesartán Almus

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartán Almus (Irbesartan)

Irbesartan, the active ingredient in Irbesartán Almus, is a angiotensin II receptor blocker presented as an oral dosage form for oral use. It is employed to treat hypertension and to protect kidney function in patients with diabetic nephropathy.

GNH India supplies Irbesartán Almus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Almus Farmaceutica S.A.

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Indications & Clinical Uses

  • Irbesartan is an angiotensin II receptor blocker that acts on the renin‑angiotensin system to control blood pressure and renal disease progression.
  • Hypertension: lowers systolic and diastolic blood pressure, reducing cardiovascular risk.
  • Diabetic nephropathy: slows the decline of renal function in patients with type 2 diabetes.

How It Works

  • Irbesartan selectively antagonizes angiotensin II type 1 (AT1) receptors on vascular smooth muscle and adrenal tissue. By blocking AT1 activation, it prevents vasoconstriction and aldosterone release, leading to vasodilation, reduced sodium‑water retention, and ultimately lower systemic blood pressure and decreased renal workload.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness, especially after the first dose.
  • Headache.
  • Fatigue or mild weakness.
  • Upper respiratory tract infection symptoms.
  • Mild gastrointestinal discomfort.

Serious or Rare Side Effects

  • Angioedema involving face, lips, tongue or airway.
  • Acute renal impairment or rise in serum creatinine.
  • Hyperkalemia, particularly in patients with renal dysfunction.
  • Hepatic injury presenting with jaundice or elevated liver enzymes.

Precautions & Warnings

Irbesartan should be used with clinical monitoring and patient education.

  • Blood pressure monitoring: check regularly to avoid hypotension.
  • Renal function assessment: evaluate serum creatinine and eGFR before and during therapy.
  • Serum potassium: monitor for hyperkalemia, especially when combined with potassium‑sparing agents.
  • Hepatic impairment: use with caution and adjust dose if needed.
  • Pregnancy: avoid use; teratogenic risk is unknown.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan may interact with several medicines that affect renal function or electrolyte balance.

Major Interactions (Avoid)

  • Concomitant use with aliskiren in diabetic patients.
  • Dual therapy with ACE inhibitors or other ARBs.
  • Potassium‑sparing diuretics (e.g., spironolactone) increasing hyperkalemia risk.
  • Lithium: may raise lithium serum levels.
  • High‑dose NSAIDs: can precipitate renal failure.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may enhance antihypertensive effect.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole) modestly increase irbesartan exposure.

Frequently Asked Questions

Irbesartán Almus contains irbesartan, an angiotensin II receptor blocker indicated for the treatment of hypertension and for slowing the progression of diabetic nephropathy in patients with type 2 diabetes.

Irbesartan blocks the angiotensin II type 1 (AT1) receptors on blood vessels and adrenal glands, preventing vasoconstriction and aldosterone release. This results in vessel relaxation, reduced sodium‑water retention, and lower blood pressure, while also decreasing stress on the kidneys.

The appropriate dose of Irbesartán Almus is determined by the prescribing clinician based on the patient’s blood pressure, kidney function, and overall health status. Dosage adjustments are made according to clinical response and tolerability.

Safety of irbesartan in pregnancy has not been established, and it is generally avoided because of potential fetal risk. Limited data exist for breastfeeding; therefore, use should be considered only if the potential benefit outweighs the possible risk to the infant.

To place an order, submit an enquiry on the Irbesartán Almus product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irbesartan belongs to the ARB class, offering blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough and angioedema. Compared with calcium‑channel blockers, ARBs act on the renin‑angiotensin system rather than directly on vascular smooth‑muscle calcium channels, providing a complementary mechanism.

Irbesartán Almus should be stored at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and do not store in humid or excessively hot environments.

Irbesartán Almus is taken orally, usually once daily with or without food. The tablet should be swallowed whole with a glass of water and not crushed or chewed, unless otherwise directed by a healthcare professional.

The most serious risks include angioedema, which can affect breathing, acute renal impairment, and significant hyperkalemia. Patients should seek immediate medical attention if they experience swelling of the face, lips, tongue, or difficulty breathing, as well as sudden changes in kidney function or elevated potassium levels.

Irbesartán Almus is contraindicated in patients with known hypersensitivity to irbesartan or any component of the formulation. It should also be avoided in individuals with severe hepatic impairment and in pregnant women, as the safety profile in these groups is not established.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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