Product image of Irbesartán Alter (Irbesartan) supplied by GNH India

Irbesartán Alter

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartán Alter (Irbesartan)

Irbesartan, the active ingredient in Irbesartán Alter, is an Angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It is employed to manage hypertension and diabetic nephropathy in adult patients.

GNH India supplies Irbesartán Alter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Alter, S.A.

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Indications & Clinical Uses

Irbesartan belongs to the ARB class and is used to treat conditions related to the renin‑angiotensin system.

  • Hypertension: lowers elevated blood pressure and reduces the risk of cardiovascular complications.
  • Diabetic nephropathy: slows progression of kidney damage in patients with type 2 diabetes by decreasing intraglomerular pressure.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors on vascular smooth muscle and adrenal tissue. By preventing angiotensin II binding, it inhibits vasoconstriction and aldosterone secretion, leading to reduced peripheral resistance, lower blood pressure, and decreased renal pressure that helps protect kidney function.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Headache: mild to moderate pain in the head region.
  • Fatigue: feeling unusually tired or weak.
  • Nasal congestion: blockage or runny nose.
  • Diarrhea: loose stools occurring intermittently.
  • Elevated potassium: mild increase in serum potassium levels.

Serious or Rare Side Effects

  • Angioedema: swelling of the face, lips, tongue, or throat that may impair breathing.
  • Acute renal failure: sudden loss of kidney function, indicated by reduced urine output.
  • Hyperkalemia: significant rise in blood potassium that can affect heart rhythm.
  • Hepatic injury: abnormal liver enzyme elevations or hepatitis.
  • Severe hypotension: abrupt, dangerous drop in blood pressure.

Precautions & Warnings

Patients should be monitored for safety and appropriate use.

  • Monitor blood pressure: check regularly to ensure therapeutic control.
  • Assess renal function: evaluate serum creatinine and eGFR before and during therapy.
  • Check electrolytes: especially potassium levels, to avoid hyperkalemia.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Avoid in pregnancy: drug may harm the fetus; discontinue if pregnancy is confirmed.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture.

Avoid Interactions

Irbesartan can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Aliskiren (in diabetic patients): combined use may increase renal risk.
  • Potassium‑sparing diuretics: may cause dangerous hyperkalemia.
  • ACE inhibitors: concurrent use raises the chance of angioedema and renal impairment.
  • Lithium: increased lithium concentrations can lead to toxicity.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may enhance antihypertensive effect, requiring dose adjustment.
  • NSAIDs: can reduce antihypertensive efficacy and affect renal function.
  • CYP2C9 inhibitors (e.g., fluconazole): may modestly increase irbesartan plasma levels.

Frequently Asked Questions

Irbesartán Alter contains irbesartan, an angiotensin II receptor blocker indicated for the management of hypertension and for slowing the progression of diabetic nephropathy in adult patients.

Irbesartan selectively blocks AT1 receptors, preventing angiotensin II from causing vasoconstriction and aldosterone release. This results in relaxed blood vessels, lower blood pressure, and reduced pressure within the kidneys, helping protect renal function.

The specific dose of Irbesartán Alter is determined by the prescribing clinician based on the patient’s blood pressure, kidney function, and overall health status. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Irbesartan is classified as contraindicated in pregnancy because it may cause fetal harm, especially in the second and third trimesters. Safety during breastfeeding has not been established, so use is generally avoided unless the benefits outweigh the risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Irbesartan belongs to the ARB class, which offers blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough and angioedema. Compared with calcium‑channel blockers, ARBs act on the renin‑angiotensin system rather than directly relaxing vascular smooth muscle.

Store Irbesartán Alter at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly sealed until use.

Irbesartán Alter is taken orally, usually with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.

The most serious risks include angioedema, which can compromise breathing, acute renal failure, and severe hyperkalemia that may affect heart rhythm. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden loss of kidney function, or marked weakness and palpitations.

Irbesartán Alter should be avoided in patients with known hypersensitivity to irbesartan or any ARB component, in those with severe hepatic impairment, and in pregnant women. Caution is also advised for individuals with existing renal dysfunction or elevated potassium levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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