Product image of Irbesartán Stada (Irbesartan) supplied by GNH India

Irbesartán Stada

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartán Stada (Irbesartan)

Irbesartan, the active ingredient in Irbesartán Stada, is an Angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It is employed to manage high blood pressure and to protect kidney function in patients with diabetes‑related kidney disease.

GNH India supplies Irbesartán Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Customers benefit from reliable supply chains, on‑time delivery, and technical support throughout the procurement process.

Manufacturer / TM Owner

Laboratorio Stada, S.L.

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Indications & Clinical Uses

Irbesartan is indicated for conditions related to the renin‑angiotensin system, primarily hypertension and diabetic kidney disease.

  • Hypertension: reduces systolic and diastolic blood pressure, lowering cardiovascular risk.
  • Diabetic nephropathy: slows progression of renal impairment in type 2 diabetes.
  • Proteinuria: decreases urinary protein excretion, supporting kidney protection.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors on vascular smooth‑muscle cells, adrenal cortex, and renal tubular cells. By preventing angiotensin II binding, it inhibits vasoconstriction, aldosterone secretion, and sympathetic activation, leading to vasodilation, reduced sodium and water retention, and lowered blood pressure. The blockade also attenuates pathogenic signaling that contributes to renal fibrosis in diabetic nephropathy.

Side Effects

Irbesartan may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Nausea
  • Elevated blood potassium

Serious or Rare Side Effects

  • Angioedema
  • Acute kidney injury
  • Hepatic dysfunction

Precautions & Warnings

When prescribing Irbesartan, clinicians should observe several precautionary measures to ensure patient safety.

  • Monitor blood pressure: adjust dose if hypotension occurs.
  • Assess renal function: check serum creatinine and eGFR before and during therapy.
  • Check electrolytes: especially potassium levels to avoid hyperkalaemia.
  • Avoid use in pregnancy: drug is contraindicated due to fetal risk.
  • Use caution in elderly: start with lower dose and monitor for orthostatic symptoms.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Irbesartan can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • ACE inhibitors + Irbesartan: increased risk of hyperkalaemia and renal impairment.
  • Aliskiren (in diabetics): heightened risk of hypotension, renal dysfunction, and hyperkalaemia.
  • Potassium‑sparing diuretics: additive hyperkalaemia.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect and affect renal function.
  • Loop or thiazide diuretics: can alter volume status and potassium balance.
  • Lithium: increased lithium concentrations, risk of toxicity.
  • CYP2C9 inhibitors (e.g., fluconazole): may raise Irbesartan plasma levels.

Frequently Asked Questions

Irbesartán Stada contains irbesartan, an angiotensin II receptor blocker that is prescribed to lower high blood pressure and to protect kidney function in patients with diabetic nephropathy. It helps reduce cardiovascular risk and slows the progression of renal disease associated with diabetes.

Irbesartan works by selectively blocking the angiotensin II type 1 (AT1) receptors on blood vessels, adrenal glands, and kidney cells. This inhibition prevents angiotensin II‑mediated vasoconstriction and aldosterone release, leading to vessel relaxation, reduced sodium‑water retention, and lower blood pressure.

The dose of Irbesartán Stada is individualized by the prescribing clinician based on the patient’s blood pressure, kidney function, and overall health status. The prescriber determines the appropriate starting dose and any subsequent adjustments.

Irbesartan is classified as Pregnancy Category D, indicating evidence of fetal risk and it is contraindicated during pregnancy. Limited data are available for breastfeeding; therefore, the drug should be used only if the potential benefit justifies the potential risk to the infant.

To order Irbesartán Stada, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irbesartan belongs to the ARB class, which offers similar blood‑pressure‑lowering efficacy to ACE inhibitors but with a lower incidence of cough and angioedema. Both classes block the renin‑angiotensin system, yet ARBs act downstream at the AT1 receptor, providing an alternative when ACE inhibitors are not tolerated.

Irbesartán Stada tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Irbesartán Stada is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and any specific dietary considerations.

The most serious adverse reactions include angioedema (swelling of the face, lips, tongue or throat), acute kidney injury, and severe liver dysfunction. Patients should seek immediate medical attention if they experience swelling, sudden loss of kidney function, or signs of liver trouble such as jaundice.

Irbesartán Stada should not be used by individuals who are pregnant, have known hypersensitivity to irbesartan or any ARB component, or have severe hepatic impairment. Caution is also advised for patients with bilateral renal artery stenosis or those on concurrent high‑dose potassium‑sparing agents.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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