Product image of Irbesartan Accord (Irbesartan) supplied by GNH India

Irbesartan Accord

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Accord (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Accord, is an angiotensin II receptor blocker presented as an oral tablet for systemic use. It is indicated for the management of hypertension and for protecting kidney function in patients with diabetic nephropathy, as well as for use in certain cases of heart failure in adults.

GNH India supplies Irbesartan Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for each batch.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Irbesartan is used to treat conditions related to the renin‑angiotensin system and cardiovascular health.

  • Hypertension: lowers blood pressure and reduces the risk of cardiovascular events.
  • Diabetic nephropathy: slows progression of kidney damage in patients with type 2 diabetes.
  • Heart failure: improves symptoms and may reduce hospitalisation in patients with reduced ejection fraction.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors, preventing angiotensin II‑mediated vasoconstriction and aldosterone release. This results in vasodilation, reduced sodium and water retention, and decreased peripheral vascular resistance, thereby lowering blood pressure and alleviating cardiac workload.

Side Effects

Common side effects are generally mild and may resolve with continued therapy.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Headache: mild to moderate pain in the head region.
  • Fatigue: feeling unusually tired or weak.
  • Nausea: upset stomach or urge to vomit.
  • Hyperkalemia (mild): slight increase in serum potassium levels.

Serious or Rare Side Effects

  • Angioedema: swelling of the face, lips, tongue or throat that may compromise breathing.
  • Severe hyperkalemia: marked elevation of potassium that can affect heart rhythm.
  • Acute renal impairment: sudden decline in kidney function.
  • Hepatic injury: signs of liver dysfunction such as jaundice.
  • Hypotension: significant drop in blood pressure causing faintness.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Monitor blood pressure: adjust dosage if target levels are not achieved.
  • Assess renal function: avoid use in patients with severe renal impairment.
  • Check serum potassium: risk of hyperkalemia, especially with potassium‑sparing agents.
  • Contraindicated in pregnancy: fetal toxicity has been reported.
  • Review concomitant medications: potential interactions may require dose adjustments.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Irbesartan may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Aliskiren in patients with diabetes: combined use can increase risk of renal dysfunction.
  • Potassium‑sparing diuretics or supplements: may cause dangerous hyperkalemia.
  • Concurrent ACE inhibitors or other ARBs: dual blockade of the renin‑angiotensin system is discouraged.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect and affect renal function.
  • Lithium: irbesartan can raise lithium concentrations, necessitating level monitoring.
  • Cyclosporine: may increase irbesartan plasma levels, requiring dose evaluation.

Frequently Asked Questions

Irbesartan Accord contains the ARB irbesartan and is prescribed to lower high blood pressure, to protect kidney function in patients with diabetic kidney disease, and to improve outcomes in certain forms of chronic heart failure.

Irbesartan blocks the angiotensin II type 1 (AT1) receptors, preventing angiotensin II from causing blood vessels to narrow and from stimulating aldosterone release. This leads to vessel relaxation, reduced fluid retention, and lower blood pressure.

The dose of Irbesartan Accord is individualized by the prescribing clinician based on the patient’s blood pressure, kidney function, and overall health. The prescriber determines the appropriate strength and dosing schedule.

Irbesartan is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as it may pass into breast milk and affect the infant. Alternative therapies should be considered.

To place an order, submit an enquiry on the Irbesartan Accord product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irbesartan belongs to the angiotensin II receptor blocker class, offering blood‑pressure control similar to other ARBs but with a lower incidence of cough compared with ACE inhibitors. It is often chosen when patients cannot tolerate ACE‑inhibitor‑related cough or angioedema.

Irbesartan Accord tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Irbesartan Accord is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless otherwise directed by a healthcare professional.

The most serious risks include angioedema, severe hyperkalemia, acute kidney injury, and significant drops in blood pressure (hypotension). Patients should seek immediate medical attention if they experience swelling of the face or throat, rapid heartbeat, or unexplained weakness.

Irbesartan Accord should not be used by individuals who are pregnant, have known hypersensitivity to irbesartan or any ARB component, or have severe renal impairment. Caution is also advised for patients with high potassium levels or those taking potassium‑increasing medicines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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