Product image of Irbesartan Accord (Irbesartan) supplied by GNH India

Irbesartan Accord

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Accord (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Accord, is an angiotensin II receptor blocker presented as a tablet for oral use. It treats hypertension and helps protect kidney function in patients with diabetic nephropathy.
GNH India supplies Irbesartan Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Irbesartan is an ARB that acts on the renin‑angiotensin system to control blood pressure and renal outcomes.

  • Hypertension: lowers systolic and diastolic blood pressure in adult patients.
  • Diabetic nephropathy: slows the progression of kidney damage in type 2 diabetes.
  • Cardiovascular risk reduction: contributes to lower incidence of cardiovascular events in patients with hypertension.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors, preventing angiotensin II from causing vasoconstriction and aldosterone release. This inhibition leads to relaxation of vascular smooth muscle, reduced peripheral resistance, and decreased sodium‑water retention, thereby lowering blood pressure and providing renal protective effects.

Side Effects

Common side effects are generally mild and reversible.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Headache: mild to moderate intensity.
  • Fatigue: feeling of tiredness without exertion.
  • Hyperkalemia: elevated blood potassium levels.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or throat requiring emergency care.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Acute renal failure: sudden loss of kidney function.
  • Hepatic injury: abnormal liver enzymes or jaundice.

Precautions & Warnings

Before initiating therapy, clinicians should assess individual risk factors and monitor relevant parameters.

  • Blood pressure monitoring: check regularly to avoid excessive hypotension.
  • Renal function: assess serum creatinine and eGFR before and during treatment.
  • Electrolytes: monitor potassium levels, especially with concomitant potassium‑sparing agents.
  • Pregnancy: avoid use in pregnancy due to potential fetal toxicity.
  • Hepatic impairment: use with caution and adjust if liver disease is present.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan may interact with several medicines, requiring attention to dosage and monitoring.

Major Interactions (Avoid)

  • Aliskiren in diabetic patients: combined use can increase renal risk.
  • Dual therapy with ACE inhibitors or other ARBs: may cause excessive potassium rise and renal impairment.
  • Potassium supplements or potassium‑sparing diuretics: risk of hyperkalemia.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may enhance antihypertensive effect, watch for hypotension.
  • Lithium: increased lithium levels, monitor for toxicity.
  • Cyclosporine: may raise serum creatinine, adjust dose as needed.
  • NSAIDs: can blunt blood‑pressure‑lowering effect, monitor response.

Frequently Asked Questions

Irbesartan Accord is prescribed to lower high blood pressure (hypertension) and to slow the progression of kidney damage in patients with diabetic nephropathy. It belongs to the angiotensin II receptor blocker class, which helps relax blood vessels and reduce fluid retention.

Irbesartan blocks the angiotensin II type 1 (AT1) receptors, preventing angiotensin II from causing blood‑vessel constriction and aldosterone release. This results in vasodilation, reduced peripheral resistance, and decreased sodium‑water retention, thereby lowering blood pressure and offering renal protection.

The specific dose of Irbesartan Accord is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and other individual factors. Dosage adjustments are made according to blood‑pressure targets and renal function.

Irbesartan is generally contraindicated during pregnancy because it may harm the developing fetus. Safety during breastfeeding has not been established, so the drug should only be used if the potential benefit outweighs the risk and after consulting a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irbesartan, as an ARB, offers blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough and angioedema. Compared with calcium‑channel blockers or diuretics, ARBs provide additional renal protection, especially in patients with diabetes, making them a preferred option in such populations.

Irbesartan Accord should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve the tablet’s stability and potency throughout its shelf life.

Irbesartan Accord is taken orally, usually once daily, with or without food. Patients should follow the prescribing clinician’s instructions regarding timing and whether the tablet should be swallowed whole or can be taken with a glass of water.

Serious risks include angioedema (swelling of the face, lips, tongue, or throat), severe hypotension, acute renal failure, and significant hyperkalemia. Patients should seek immediate medical attention if they experience any signs of these conditions.

Irbesartan Accord should be avoided in patients with known hypersensitivity to irbesartan or any ARB component, in pregnant women, and in individuals with severe hepatic impairment unless specifically directed by a physician. Caution is also advised for patients with existing renal dysfunction or high potassium levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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