Product image of Irbesartan Aurobindo (Irbesartan) supplied by GNH India

Irbesartan Aurobindo

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Aurobindo (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Aurobindo, is an angiotensin II receptor blocker presented as an oral tablet for oral use. It works by selectively blocking the AT₁ receptor, thereby reducing vasoconstriction and aldosterone release, which helps to lower elevated blood pressure and slow the progression of kidney damage in patients with diabetic nephropathy.

GNH India supplies Irbesartan Aurobindo as a licensed, GMP‑qualified product sourced from the European Union, providing a GDP‑compliant solution to hospitals, pharmacies and clinics worldwide and health‑care networks.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

  • Irbesartan belongs to the angiotensin II receptor blocker class and is used to manage conditions related to the renin‑angiotensin system.
  • Hypertension: lowers systolic and diastolic blood pressure in adults.
  • Diabetic nephropathy: slows decline of renal function in patients with type 2 diabetes.
  • Proteinuria in diabetic kidney disease: reduces urinary protein excretion, contributing to renal protection.

How It Works

  • Irbesartan selectively antagonizes the AT₁ subtype of the angiotensin II receptor, preventing angiotensin II‑mediated vasoconstriction, aldosterone secretion, and sympathetic activation. This blockade leads to vasodilation, reduced sodium and water retention, and ultimately lower systemic blood pressure while offering renal protective effects in diabetic patients.

Side Effects

Irbesartan is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Headache: mild to moderate pain in the head region.
  • Fatigue: feeling unusually tired or weak.
  • Hyperkalemia: elevated blood potassium detected on laboratory testing.

Serious or Rare Side Effects

  • Angioedema: swelling of the face, lips, tongue, or throat that may compromise breathing.
  • Severe hypotension: marked drop in blood pressure causing faintness or shock.
  • Acute renal impairment: sudden worsening of kidney function, indicated by rising creatinine levels.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Monitor blood pressure: ensure adequate control without excessive lowering.
  • Assess renal function: check serum creatinine and eGFR at baseline and periodically.
  • Check serum potassium: avoid hyperkalemia, especially when combined with potassium‑sparing agents.
  • Use caution in hepatic impairment: dose adjustments may be required.
  • Pregnancy warning: contraindicated in pregnancy (Category D) due to fetal toxicity.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Irbesartan may interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Aliskiren in diabetic patients: combined use can increase risk of renal dysfunction and hyperkalemia.
  • ACE inhibitors or other ARBs: concurrent therapy may cause excessive potassium rise and renal impairment.
  • Potassium‑sparing diuretics or supplements: heightened risk of hyperkalemia.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect and affect renal function.
  • Thiazide diuretics: additive blood‑pressure lowering, requiring dose titration.
  • Lithium: irbesartan can raise lithium concentrations, increasing toxicity risk.

Frequently Asked Questions

Irbesartan Aurobindo is an oral angiotensin II receptor blocker prescribed to lower high blood pressure and to protect kidney function in patients with diabetic nephropathy. It helps reduce cardiovascular risk associated with hypertension and slows the progression of renal disease in diabetes.

Irbesartan selectively blocks the AT₁ receptor for angiotensin II, preventing the hormone from causing blood‑vessel constriction and aldosterone release. This results in vasodilation, reduced sodium and water retention, and lower systemic blood pressure, while also offering renal protective effects.

The dose of Irbesartan Aurobindo is individualized by the prescribing clinician based on the patient’s blood‑pressure targets, renal function, and overall health status. The prescriber determines the appropriate strength and dosing schedule.

Irbesartan is classified as pregnancy Category D because it can cause fetal harm, especially in the second and third trimesters. It is not recommended for use during pregnancy. Limited data exist for breastfeeding, so the drug should be avoided unless the benefits clearly outweigh the risks.

To order Irbesartan Aurobindo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Irbesartan belongs to the ARB class, which offers blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough and angioedema. Compared with calcium‑channel blockers, ARBs primarily affect the renin‑angiotensin system, making them especially useful for patients with diabetic kidney disease.

Irbesartan Aurobindo tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect from moisture and light. Keep the product out of reach of children and do not use after the expiry date printed on the label.

Irbesartan Aurobindo is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing instructions provided by their healthcare professional.

Serious risks include angioedema, which can cause swelling of the face or throat and threaten breathing, severe hypotension leading to fainting or shock, and acute renal impairment indicated by a rapid rise in serum creatinine. Prompt medical attention is required if any of these occur.

Irbesartan Aurobindo should not be used by patients with known hypersensitivity to irbesartan or any ARB, those with bilateral renal artery stenosis, or women who are pregnant. Caution is also advised in individuals with severe hepatic impairment or advanced kidney disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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