Product image of Irbesartan Basi (Irbesartan) supplied by GNH India

Irbesartan Basi

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Basi (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Basi, is a Angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It treats hypertension and related cardiovascular conditions in adults.

GNH India supplies Irbesartan Basi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratórios Basi – Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

  • Irbesartan is an angiotensin II receptor blocker that acts on the renin‑angiotensin system to manage several cardiovascular and renal conditions.
  • Hypertension: lowers blood pressure and reduces risk of cardiovascular events.
  • Diabetic nephropathy: slows progression of kidney damage in patients with type 2 diabetes.
  • Heart failure: improves symptoms and decreases hospitalizations in chronic heart failure patients.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors on vascular smooth muscle, adrenal gland and renal tubular cells. By preventing angiotensin II binding, it inhibits vasoconstriction, aldosterone release and sympathetic activation, leading to vasodilation, reduced sodium and water retention, and lower systemic blood pressure. The blockade also attenuates pathological remodeling of the heart and kidneys.

Side Effects

Irbesartan may cause adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Nasal congestion
  • Diarrhea

Serious or Rare Side Effects

  • Angioedema (swelling of face, lips, tongue)
  • Severe hypotension (marked drop in blood pressure)
  • Acute kidney injury (sudden decline in renal function)
  • Elevated liver enzymes (signs of hepatic injury)

Precautions & Warnings

When prescribing Irbesartan, clinicians should consider several precautionary measures to ensure safe use.

  • Monitor blood pressure: check regularly to assess therapeutic response.
  • Assess renal function: evaluate serum creatinine and eGFR before and during treatment.
  • Check serum potassium: watch for hyperkalaemia, especially with concomitant potassium‑sparing agents.
  • Use cautiously in hepatic impairment: dose adjustment may be required.
  • Avoid use in pregnancy: drug is contraindicated due to risk of fetal toxicity.
  • Store at ambient temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Irbesartan can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Aliskiren in patients with diabetes: combined use may increase risk of renal dysfunction, hyperkalaemia, and hypotension.
  • Potassium‑sparing diuretics (e.g., spironolactone): may cause dangerous elevations in serum potassium.
  • ACE inhibitors: concurrent use can lead to additive renal impairment and hyperkalaemia.

Moderate Interactions (Monitor Closely)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase Irbesartan plasma concentrations.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce Irbesartan effectiveness.

Frequently Asked Questions

Irbesartan Basi contains the ARB Irbesartan and is prescribed to lower high blood pressure, to slow the progression of kidney disease in patients with type 2 diabetes (diabetic nephropathy), and to improve symptoms and outcomes in chronic heart failure.

Irbesartan blocks the angiotensin II type 1 (AT1) receptors, preventing angiotensin II from causing blood vessels to narrow and from stimulating aldosterone release. This results in vasodilation, reduced fluid retention, and lower systemic blood pressure, while also limiting harmful cardiac and renal remodeling.

The exact dose of Irbesartan Basi is determined by the prescribing clinician based on the individual’s blood pressure, kidney function, and other medical factors. The prescriber will select an appropriate strength and dosing schedule that best fits the patient’s therapeutic needs.

Irbesartan is contraindicated in pregnancy because it can cause fetal toxicity, including renal failure and death. Limited data are available for breastfeeding; therefore, the drug is generally not recommended for nursing mothers unless the potential benefit justifies the potential risk.

To order Irbesartan Basi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irbesartan belongs to the ARB class, which offers blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough and angioedema. Compared with calcium‑channel blockers or diuretics, ARBs provide additional renal protection in diabetic patients and are often combined with those agents for synergistic effect.

Irbesartan Basi tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Irbesartan Basi is taken orally, usually once daily. The tablet should be swallowed whole with a glass of water and can be taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare professional.

The most serious adverse events include hyperkalaemia (elevated potassium levels), acute kidney injury, severe hypotension, and angioedema. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, or a marked decrease in urine output.

Irbesartan Basi should not be used by individuals who are pregnant, have known hypersensitivity to Irbesartan or any ARB, or have severe hepatic impairment. Caution is also advised for patients with existing renal dysfunction, high potassium levels, or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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