Product image of Irbesartan Clonmel (Irbesartan) supplied by GNH India

Irbesartan Clonmel

Active Ingredient:
Irbesartan
Origin:
EU

Irbesartan Clonmel (Irbesartan)

Irbesartan, the active ingredient in Irbesartan Clonmel, is an Angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It is prescribed to manage high blood pressure and to protect kidney function in patients with diabetes‑related kidney disease.

GNH India supplies Irbesartan Clonmel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Clonmel Healthcare Ltd.

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Indications & Clinical Uses

  • Irbesartan is an ARB that acts on the renin‑angiotensin system to control blood pressure and renal outcomes.
  • Hypertension: lowers systolic and diastolic pressure, reducing the risk of cardiovascular events.
  • Diabetic nephropathy: slows the progression of kidney damage in patients with type 2 diabetes, helping preserve renal function.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors on vascular smooth muscle and adrenal tissue. By preventing angiotensin II binding, it inhibits vasoconstriction and aldosterone secretion, leading to vasodilation, reduced sodium‑water retention, and lower blood pressure, while also decreasing intraglomerular pressure in the kidneys.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue
  • Upper respiratory tract infection
  • Nausea

Serious or Rare Side Effects

  • Angioedema (swelling of face, lips, tongue)
  • Hyperkalemia (elevated blood potassium)
  • Acute renal impairment or failure
  • Hepatic injury (elevated liver enzymes or hepatitis)

Precautions & Warnings

Patients should be monitored for safety and appropriate use.

  • Blood pressure monitoring: check regularly to ensure therapeutic effect.
  • Renal function assessment: evaluate serum creatinine and eGFR before and during therapy.
  • Electrolyte surveillance: monitor potassium levels, especially if combined with potassium‑sparing agents.
  • Hepatic impairment: use with caution in patients with severe liver disease.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan may interact with several medicines; clinical judgment is required.

Major Interactions (Avoid)

  • Concomitant aliskiren in diabetic patients: increased risk of renal dysfunction.
  • Dual therapy with ACE inhibitors or other ARBs: heightened risk of hyperkalemia and renal impairment.
  • Potassium‑sparing diuretics (e.g., spironolactone): may cause dangerous potassium elevation.
  • High‑dose NSAIDs in patients with compromised renal function.

Moderate Interactions (Monitor Closely)

  • Lithium: may increase lithium concentrations.
  • Cyclosporine or tacrolimus: can raise serum creatinine.
  • NSAIDs (regular dose): may reduce antihypertensive effect.
  • Thiazide diuretics: may enhance hypotensive response.

Frequently Asked Questions

Irbesartan Clonmel is prescribed primarily to treat hypertension and to slow the progression of diabetic nephropathy. By lowering blood pressure and reducing kidney strain, it helps protect cardiovascular health and renal function in patients with high blood pressure or type‑2 diabetes‑related kidney disease.

Irbesartan blocks the angiotensin II type 1 (AT1) receptors on blood vessels and adrenal glands. This inhibition prevents angiotensin II‑induced vasoconstriction and aldosterone release, leading to vessel relaxation, reduced sodium‑water retention, lower blood pressure, and decreased pressure within the kidney’s filtering units.

The appropriate dose of Irbesartan Clonmel is determined by the prescribing clinician based on the individual’s blood pressure, kidney function, and overall health status. Dosage adjustments are made according to therapeutic response and tolerability, following local prescribing guidelines.

Safety of Irbesartan in pregnancy has not been established, and it is generally avoided because of potential fetal toxicity. Limited data exist for breastfeeding; therefore, the drug should be used only if the potential benefit outweighs the risk, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Irbesartan belongs to the ARB class, offering blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough and angioedema. Compared with calcium‑channel blockers or diuretics, ARBs specifically target the renin‑angiotensin system, making them especially useful in patients with diabetic kidney disease.

Irbesartan Clonmel tablets should be stored at room temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Irbesartan Clonmel is taken orally, usually once daily, with or without food. Patients should swallow the tablet whole with a glass of water and follow the dosing schedule prescribed by their healthcare professional.

Serious risks include angioedema, which can cause swelling of the face, lips, tongue or throat, and hyperkalemia, a potentially life‑threatening rise in blood potassium. Acute renal impairment may also occur, especially when combined with other nephrotoxic agents. Prompt medical attention is required if any of these symptoms develop.

Irbesartan Clonmel is contraindicated in patients with known hypersensitivity to irbesartan or any component of the formulation. It should also be avoided in individuals with severe hepatic impairment and in those taking dual renin‑angiotensin system blockers (e.g., ACE inhibitor plus ARB) unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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