Product image of Irbesartan Comp. Abz (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Irbesartan Comp. Abz

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Irbesartan Comp. Abz (Hydrochlorothiazide, Irbesartan)

Irbesartan, the active ingredient in Irbesartan Comp. Abz, is an Angiotensin II receptor blocker presented as an oral tablet formulation for oral use. It is combined with hydrochlorothiazide to treat hypertension in adult patients, helping to lower elevated blood pressure. It is indicated for patients who require combined antihypertensive therapy to achieve target blood pressure levels.

GNH India supplies Irbesartan Comp. Abz as a licensed, GDP‑compliant international pharmaceutical supplier, adhering to EU quality standards and providing the product to hospitals, pharmacies and clinics worldwide through regulated distribution channels.

Manufacturer / TM Owner

Abz-Pharma Gmbh

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Indications & Clinical Uses

Irbesartan/Hydrochlorothiazide is used in the management of hypertension, a condition characterized by elevated arterial pressure.

  • Hypertension: lowers systolic and diastolic blood pressure to reduce cardiovascular risk.
  • Hypertension in type 2 diabetes: assists in blood pressure control while offering renal protective effects.
  • Hypertension with fluid retention: combines vasodilation and diuresis to reduce excess fluid and improve blood pressure control.

How It Works

  • Irbesartan selectively blocks AT1 angiotensin II receptors, preventing vasoconstriction and aldosterone release, which leads to relaxed blood vessels and reduced sodium retention. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, increasing urinary excretion of water and electrolytes, thereby decreasing plasma volume and further lowering blood pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness.
  • Headache.
  • Increased urination.
  • Electrolyte disturbances, such as low potassium.
  • Mild gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe allergic reactions (rash, swelling, difficulty breathing).
  • Acute kidney injury or worsening renal function.
  • Significant hypotension (dangerously low blood pressure).
  • Hyperkalemia (high potassium levels).
  • Pancreatitis.
  • Blood dyscrasias (e.g., agranulocytosis).

Precautions & Warnings

Patients should be monitored regularly while taking this medication.

  • Monitor blood pressure: ensure therapeutic targets are reached without excessive lowering.
  • Assess renal function: check serum creatinine and eGFR before initiation and periodically thereafter.
  • Check electrolytes: especially potassium and sodium levels during therapy.
  • Avoid use in pregnancy: the drug is contraindicated due to fetal risk.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan/Hydrochlorothiazide may interact with several medicines.

Major Interactions (Avoid)

  • Aliskiren in patients with diabetes: increased risk of renal impairment.
  • Potassium‑sparing diuretics or potassium supplements: may cause hyperkalemia.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): can diminish antihypertensive effect and affect kidney function.

Moderate Interactions (Monitor Closely)

  • Other antihypertensive agents: additive blood pressure‑lowering effect.
  • Lithium: may increase lithium concentrations.
  • Cyclosporine: can raise serum creatinine levels.

Frequently Asked Questions

Irbesartan Comp. Abz is prescribed to lower high blood pressure in adults. It combines the angiotensin II receptor blocker irbesartan with the thiazide diuretic hydrochlorothiazide, providing both vasodilation and increased urine output to achieve better blood‑pressure control.

Irbesartan blocks AT1 receptors for angiotensin II, preventing the hormone from narrowing blood vessels and stimulating aldosterone release. This results in relaxed arteries and reduced fluid retention, helping to lower systemic blood pressure.

The specific dose of Irbesartan Comp. Abz is determined by the prescribing clinician based on the patient’s blood‑pressure readings, overall health, and other medications. Only a qualified health professional should set the appropriate dosage.

Irbesartan Comp. Abz is classified as Pregnancy Category D, indicating evidence of fetal risk. It should not be used during pregnancy. Limited data are available for breastfeeding; the decision to use it while nursing should be made by a physician after weighing potential benefits and risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with single‑agent ARBs or ACE inhibitors, Irbesartan Comp. Abz adds a thiazide diuretic, which can improve blood‑pressure reduction in patients who need additional control. It offers a convenient fixed‑dose combination, reducing pill burden, but may carry a higher risk of electrolyte changes than monotherapy.

Store the tablets at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Irbesartan Comp. Abz is taken orally, usually once daily, with or without food, as directed by a healthcare professional. Swallow the tablet whole with a glass of water; do not crush or split it unless instructed by a pharmacist.

Serious risks include severe allergic reactions, significant drops in blood pressure, kidney impairment, hyperkalemia, and rare blood disorders. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, sudden weakness, or unusual bruising.

Individuals with known hypersensitivity to irbesartan, hydrochlorothiazide, or any component of the formulation should avoid the product. It is also contraindicated in pregnancy, and caution is advised for patients with severe renal impairment, hyperkalemia, or those taking interacting medications such as aliskiren in diabetes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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