Product image of Irbesartan/Hct Al (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Irbesartan/Hct Al

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Irbesartan/Hct Al (Hydrochlorothiazide, Irbesartan)

Irbesartan/Hydrochlorothiazide, the active ingredient in Irbesartan/Hct Al, is an angiotensin II receptor blocker (ARB) and thiazide diuretic presented as an oral tablet for oral use. It lowers elevated blood pressure and is prescribed for adults with hypertension.

GNH India supplies Irbesartan/Hct Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Irbesartan/Hct Al is used to manage high blood pressure within the antihypertensive drug class.

  • Essential hypertension: provides additive blood‑pressure reduction when monotherapy is insufficient.
  • Secondary hypertension: assists in controlling blood pressure caused by identifiable underlying conditions.
  • Hypertension with fluid retention: combines vasodilation and diuresis to improve overall pressure control.

How It Works

  • Irbesartan selectively blocks the angiotensin II type 1 (AT1) receptor, preventing vasoconstriction and aldosterone release, which leads to vessel relaxation and reduced sodium‑water retention. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, promoting diuresis and decreasing plasma volume. The complementary actions produce an additive antihypertensive effect.

Side Effects

Common side effects are generally mild and may resolve with continued therapy.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)
  • Mild gastrointestinal upset

Serious or Rare Side Effects

  • Severe dehydration or electrolyte imbalance
  • Acute kidney injury
  • Hyperuricemia or gout flare
  • Angioedema
  • Hepatic dysfunction
  • Severe hypotension

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Pregnancy: Category D – avoid use unless clearly needed.
  • Renal impairment: monitor kidney function and adjust dose if required.
  • Hepatic disease: use with caution; monitor liver enzymes.
  • Electrolyte balance: check serum potassium and sodium regularly.
  • Concomitant diuretics: assess risk of excessive diuresis.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan/Hct Al may interact with several medicines; categorize the risk level.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.
  • Lithium: increased lithium levels, potential toxicity.
  • NSAIDs: may reduce antihypertensive efficacy and affect renal function.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or other ARBs: additive blood‑pressure effect, monitor for hypotension.
  • Antidiabetic agents: may enhance hypoglycemic response.
  • CYP2C9 inhibitors (e.g., fluconazole): may increase irbesartan concentrations.

Frequently Asked Questions

Irbesartan/Hct Al is a fixed‑dose combination of irbesartan and hydrochlorothiazide indicated for the treatment of hypertension. It is prescribed when blood‑pressure control requires both an angiotensin II receptor blocker and a thiazide diuretic to achieve target levels.

Irbesartan blocks the angiotensin II type 1 (AT1) receptor, preventing the hormone from causing vasoconstriction and aldosterone release. This results in relaxed blood vessels and reduced sodium‑water retention, helping to lower blood pressure.

The specific dose of Irbesartan/Hct Al is determined by the prescribing clinician based on the patient’s blood‑pressure readings, renal function, and overall health status. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Irbesartan/Hct Al is classified as Pregnancy Category D, indicating potential risk to the fetus and should be avoided unless the benefit outweighs the risk. It is also not recommended for breastfeeding mothers because it may pass into breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with monotherapy agents, the Irbesartan/Hct Al combination offers additive blood‑pressure reduction by pairing an ARB with a thiazide diuretic. This can simplify regimens, improve adherence, and achieve better control than using either component alone, especially in patients who need multiple mechanisms of action.

Store Irbesartan/Hct Al tablets at room temperature, below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed to maintain stability.

Irbesartan/Hct Al is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.

Serious risks include severe dehydration, electrolyte imbalances (especially low potassium), acute kidney injury, and rare cases of angioedema. Patients should be monitored for signs of these conditions, and any sudden symptoms should prompt immediate medical evaluation.

Irbesartan/Hct Al should be avoided in patients with known hypersensitivity to irbesartan, hydrochlorothiazide, or any component of the formulation. It is also contraindicated in individuals with severe renal impairment, anuria, or those who are pregnant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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