Product image of Irbesartan Hctz Fair-Med (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Irbesartan Hctz Fair-Med

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Irbesartan Hctz Fair-Med (Hydrochlorothiazide, Irbesartan)

Irbesartan, the active ingredient in Irbesartan Hctz Fair-Med, is an angiotensin II receptor blocker presented as a combination tablet for oral use. It treats hypertension in adult patients by relaxing blood vessels and reducing fluid retention.

GNH India supplies Irbesartan Hctz Fair-Med as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fairmed Healthcare Gmbh

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Indications & Clinical Uses

Irbesartan/Hydrochlorothiazide acts on the renin‑angiotensin‑aldosterone system and renal sodium handling to lower blood pressure in hypertensive patients.

  • Essential hypertension: reduces systolic and diastolic pressure to target levels.
  • Hypertension with fluid retention: improves control by adding diuretic‑induced natriuresis.
  • Patients needing combination therapy: achieves blood‑pressure goals when monotherapy is insufficient.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone‑mediated sodium retention. Hydrochlorothiazide inhibits the Na⁺/Cl⁻ symporter in the distal convoluted tubule, promoting urinary excretion of sodium and water, which together lower systemic vascular resistance and plasma volume, resulting in reduced arterial pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue or weakness
  • Increased urinary frequency
  • Electrolyte disturbances (e.g., low potassium)
  • Mild rise in serum creatinine

Serious or Rare Side Effects

  • Severe dehydration or electrolyte imbalance
  • Acute kidney injury or significant rise in creatinine
  • Hyperkalemia, especially with potassium‑sparing agents
  • Anaphylactic or severe allergic reactions
  • Pancreatitis
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

Before initiating therapy, clinicians should assess renal function, electrolyte status, and blood pressure response.

  • Monitor blood pressure regularly: adjust therapy if target not reached.
  • Check renal function and serum electrolytes: especially potassium and creatinine.
  • Use caution in patients with hepatic impairment: dose may need adjustment.
  • Avoid in severe dehydration or volume depletion: may worsen hypotension.
  • Counsel diabetic patients: diuretic effect can affect glucose control.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan/HCTZ can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Concomitant use with aliskiren in diabetic patients: increased risk of renal impairment.
  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.
  • NSAIDs (e.g., ibuprofen, naproxen): may reduce antihypertensive effect and impair renal function.
  • Lithium: thiazide component can raise lithium levels, leading to toxicity.
  • Other potent antihypertensives: additive hypotensive effect.

Moderate Interactions (Monitor Closely)

  • CYP2C9 inhibitors (e.g., fluconazole): may increase irbesartan plasma concentrations.
  • Additional thiazide or loop diuretics: risk of excessive diuresis and electrolyte loss.
  • Antidiabetic agents: thiazide may raise blood glucose, requiring dose adjustment.
  • Warfarin: monitor INR as thiazide can affect anticoagulation control.
  • Digoxin: monitor serum levels due to potential changes in renal clearance.

Frequently Asked Questions

Irbesartan Hctz Fair-Med is a prescription oral tablet that combines irbesartan and hydrochlorothiazide to treat hypertension. The irbesartan component blocks angiotensin II receptors, while the hydrochlorothiazide component promotes sodium and water excretion, together helping to lower elevated blood pressure in adult patients.

Irbesartan selectively blocks the angiotensin II type 1 (AT1) receptors, preventing the hormone from causing blood‑vessel constriction and aldosterone‑driven sodium retention. This results in vasodilation and reduced fluid volume, which together lower systemic blood pressure.

The appropriate dose of Irbesartan Hctz Fair-Med is determined by the prescribing clinician based on the patient’s blood‑pressure profile, renal function, and other individual factors. Patients should follow the dosage instructions provided by their healthcare professional and not adjust the dose on their own.

Safety of Irbesartan Hctz Fair-Med in pregnancy and lactation has not been established. Because angiotensin‑II receptor blockers may cause fetal harm, the product is generally avoided during pregnancy. Breastfeeding mothers should consult their physician, as the drug may be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with monotherapy agents, the Irbesartan/HCTZ combination offers dual mechanisms—vasodilation from irbesartan and diuresis from hydrochlorothiazide—allowing better blood‑pressure control in patients who need more than one drug class. It can reduce pill burden versus taking separate agents, but clinicians must monitor for additive side effects such as electrolyte changes.

Store the tablets at room temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat, and direct sunlight. Keep the product out of reach of children and do not use if the packaging is damaged.

Irbesartan Hctz Fair-Med is taken orally, usually once daily, with a full glass of water. It may be taken with or without food, but consistent administration with respect to meals helps maintain stable drug levels. Swallow the tablet whole; do not crush or chew it.

Serious risks include severe dehydration, acute kidney injury, hyperkalemia (especially when combined with potassium‑sparing agents), and rare allergic reactions such as anaphylaxis. Patients should report symptoms like sudden weakness, swelling, difficulty breathing, or a marked drop in urine output to their healthcare provider promptly.

The medication is contraindicated in patients with severe renal impairment, hyperkalemia, known hypersensitivity to irbesartan or hydrochlorothiazide, and in women who are pregnant. Caution is also advised for individuals with hepatic disease, severe dehydration, or those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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