Product image of Irbesartan + Hidroclorotiazida Beapy Bluemed Unipessoal, Lda (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Irbesartan + Hidroclorotiazida Beapy Bluemed Unipessoal, Lda

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Irbesartan + Hidroclorotiazida Beapy Bluemed Unipessoal, Lda (Hydrochlorothiazide, Irbesartan)

Irbesartan, the active ingredient in Irbesartan + Hydrochlorothiazide, is an Angiotensin II receptor blocker presented as a combined tablet for oral use. It is employed to lower blood pressure in adults with essential hypertension, often when additional control beyond monotherapy is required.

GNH India supplies Irbesartan + Hydrochlorothiazide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance through its global distribution network. The company adheres to stringent manufacturing standards and provides reliable logistics for timely delivery to healthcare providers.

Manufacturer / TM Owner

Bluemed Unipessoal, Lda

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Indications & Clinical Uses

  • Irbesartan/Hydrochlorothiazide is an antihypertensive combination that lowers blood pressure by blocking the renin‑angiotensin system and enhancing diuresis.
  • Essential hypertension: reduces systolic and diastolic pressure in patients with primary high blood pressure.
  • Resistant hypertension: provides additional blood‑pressure control when a single agent is insufficient.
  • Hypertension with fluid retention: helps manage blood pressure while decreasing excess extracellular fluid.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction, aldosterone release, and sympathetic activation. Hydrochlorothiazide acts on the distal convoluted tubule, inhibiting NaCl reabsorption, which promotes natriuresis and diuresis, reducing plasma volume. This dual mechanism allows for synergistic reduction of arterial pressure and improves control in patients who do not achieve target values with monotherapy.

Side Effects

Like all antihypertensive agents, Irbesartan/Hydrochlorothiazide may cause adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Increased urination

Serious or Rare Side Effects

  • Severe dehydration
  • Acute kidney injury
  • Angioedema

Precautions & Warnings

  • Precautions for Irbesartan/Hydrochlorothiazide focus on renal function, electrolyte balance, and specific patient populations.
  • Monitor renal function: assess serum creatinine and eGFR before initiation and periodically during therapy.
  • Check electrolytes: watch for sodium and potassium abnormalities, especially hypokalemia.
  • Avoid use in pregnancy: contraindicated in the second and third trimesters due to fetal risk.
  • Use cautiously in elderly: increased susceptibility to hypotension and electrolyte shifts.
  • Review concomitant medications: NSAIDs, lithium, and other diuretics may amplify adverse effects.
  • Store at ambient temperature: keep tablets in original container, protect from moisture and light.

Avoid Interactions

Irbesartan/Hydrochlorothiazide can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • ACE inhibitor or ARB combination: risk of hyperkalemia and renal dysfunction.
  • Potassium‑sparing diuretics: may cause dangerous potassium elevation.
  • Lithium: increased lithium concentrations leading to toxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: can reduce antihypertensive effect and affect kidney function.
  • CYP2C9 inhibitors (e.g., fluconazole): may raise irbesartan levels.

Frequently Asked Questions

Irbesartan + Hydrochlorothiazide is prescribed to treat hypertension, particularly when a single antihypertensive agent does not achieve target blood‑pressure levels. The combination leverages an angiotensin II receptor blocker and a thiazide diuretic to provide additive blood‑pressure reduction.

Irbesartan blocks angiotensin II type 1 (AT1) receptors, preventing the hormone from causing vasoconstriction and stimulating aldosterone release. This leads to relaxed blood vessels and reduced fluid retention, contributing to lower systemic blood pressure.

The appropriate dose is individualized by the prescribing clinician based on the patient’s blood‑pressure response, renal function, and other medical considerations. Physicians select the tablet strength and dosing frequency that best meet the therapeutic goal.

The combination is classified as pregnancy category D, indicating evidence of fetal risk. It should not be used during the second or third trimester, and breastfeeding mothers should avoid it unless the benefits outweigh the potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other ARB‑thiazide combos such as Losartan/HCTZ, Irbesartan offers similar blood‑pressure lowering efficacy but may have a slightly different side‑effect profile, particularly regarding potassium balance. Choice often depends on patient tolerance, comorbid conditions and physician preference.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf life.

The medication is taken orally, usually once daily, with a full glass of water. It may be taken with or without food, but consistent timing each day helps maintain stable blood‑pressure control.

Serious adverse events include severe dehydration, acute kidney injury, and angioedema, which can be life‑threatening. Patients should seek immediate medical attention if they experience rapid weight loss, swelling of the face or throat, or a sudden decline in kidney function.

The combination is contraindicated in patients with known hypersensitivity to either component, those with severe renal impairment, and pregnant women in the second or third trimester. Caution is also advised for individuals with electrolyte disorders such as hyperkalemia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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