Product image of Irbesartan/Hydrochloorthiazide Stada (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Irbesartan/Hydrochloorthiazide Stada

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Irbesartan/Hydrochloorthiazide Stada (Hydrochlorothiazide, Irbesartan)

Irbesartan, the active ingredient in Irbesartan/Hydrochloorthiazide Stada, is an Angiotensin II receptor blocker (ARB) presented as a fixed‑dose oral tablet for oral use. It treats hypertension in adult patients by lowering elevated blood pressure.

GNH India supplies Irbesartan/Hydrochloorthiazide Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Irbesartan/Hydrochlorothiazide is used in the management of hypertension, a condition characterized by chronically elevated arterial pressure.

  • Hypertension: reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications.
  • Essential hypertension: provides combined ARB and thiazide diuretic action for better blood‑pressure control.
  • High blood pressure: improves overall vascular resistance and fluid balance.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release, while hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, promoting diuresis. The combined effect lowers peripheral vascular resistance and reduces plasma volume, resulting in decreased blood pressure.

Side Effects

Common Side Effects

  • Dizziness: feeling light‑headed, especially after standing.
  • Headache: mild to moderate pain in the head region.
  • Fatigue: general tiredness or lack of energy.
  • Increased urination: more frequent bathroom visits due to diuretic action.
  • Electrolyte imbalance: mild reductions in potassium or sodium levels.
  • Mild gastrointestinal discomfort: occasional nausea or abdominal pain.

Serious or Rare Side Effects

  • Severe dehydration: marked fluid loss requiring medical attention.
  • Acute kidney injury: sudden decline in renal function.
  • Hyperkalemia: dangerously high potassium levels.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Blood disorders: leukopenia, thrombocytopenia, or agranulocytosis.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Blood pressure monitoring: regularly check to ensure therapeutic targets are met.
  • Renal function assessment: evaluate serum creatinine and eGFR, especially in patients with pre‑existing kidney disease.
  • Electrolyte surveillance: monitor potassium and sodium levels during treatment.
  • Caution in elderly: dose adjustments may be needed due to altered pharmacokinetics.
  • Avoid in severe hepatic impairment: limited data support safe use.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan/Hydrochlorothiazide may interact with several medicines. Review the following groups:

Major Interactions (Avoid)

  • Aliskiren: combined use can increase risk of renal dysfunction and hyperkalemia.
  • Potassium‑sparing diuretics: may cause dangerous elevations in serum potassium.
  • NSAIDs: can blunt antihypertensive effect and impair renal function.
  • Lithium: increased lithium levels leading to toxicity.
  • ACE inhibitors: additive risk of hyperkalemia and renal impairment.

Moderate Interactions (Monitor Closely)

  • Other thiazide diuretics: may enhance diuretic‑related electrolyte loss.
  • Antihypertensive agents: may require dose adjustment to avoid excessive hypotension.
  • Antidiabetic drugs: diuretic effect can alter glucose control.
  • Antidepressants (SSRIs): potential for increased hyponatremia.
  • Rifampin: may reduce plasma concentrations of irbesartan.

Frequently Asked Questions

Irbesartan/Hydrochlorothiazide is a fixed‑dose combination medication used to treat hypertension. By combining an angiotensin II receptor blocker with a thiazide diuretic, it helps lower blood pressure more effectively than either component alone, reducing the risk of cardiovascular events in patients with high blood pressure.

Irbesartan blocks the angiotensin II type 1 (AT1) receptors, preventing angiotensin II from causing vasoconstriction and stimulating aldosterone release. This leads to relaxation of blood vessels and reduced sodium and water retention, contributing to lower blood pressure.

The specific dose of Irbesartan/Hydrochlorothiazide is determined by the prescribing healthcare professional based on the patient’s clinical condition, blood pressure response, and renal function. Patients should follow the dosage instructions provided by their prescriber and not adjust the dose on their own.

Safety of Irbesartan/Hydrochlorothiazide during pregnancy has not been established, and it is generally avoided because of potential risks to the fetus. Limited data are available for breastfeeding; therefore, the medication should only be used if the benefits outweigh potential risks, under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Compared with monotherapy agents, the Irbesartan/Hydrochlorothiazide combination offers dual mechanisms—vascular relaxation and diuresis—in a single tablet, often achieving better blood‑pressure control and improving patient adherence. It is frequently preferred over separate prescriptions of an ARB and a thiazide diuretic.

Store the tablets at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep them out of reach of children and do not use if the packaging is damaged.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew it unless specifically instructed.

Serious risks include severe dehydration, acute kidney injury, hyperkalemia, and allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like rapid weight loss, swelling, difficulty breathing, or a sudden drop in urine output.

Individuals with known hypersensitivity to irbesartan, hydrochlorothiazide, or any component of the formulation should avoid this medication. It is also contraindicated in patients with severe renal impairment, anuria, or those taking potassium‑sparing diuretics without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Hydrochlorothiazide, Irbesartan

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT