Irbesartan/Hydrochloorthiazide Xiromed (Hydrochlorothiazide, Irbesartan)

Irbesartan blocks the AT1 receptors for angiotensin II, preventing the hormone from causing blood vessels to narrow and reducing aldosterone‑mediated sodium retention. This leads to vasodilation and lower blood pressure, complementing the diuretic effect of hydrochlorothiazide.

The appropriate dose is determined by the prescribing clinician based on the patient’s blood‑pressure readings, kidney function, and overall health. Dosage may be adjusted over time to achieve optimal control while minimizing side effects.

Safety in pregnancy and lactation has not been established. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and it is typically avoided unless specifically recommended by a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with monotherapy agents, the combination offers dual mechanisms—vascular relaxation from the ARB and fluid removal from the thiazide—often achieving better blood‑pressure control at lower individual doses. It may be preferred over separate tablets for convenience and adherence.

Store the product at temperatures below 25 °C in its original packaging. Protect it from moisture, direct sunlight and excessive heat to maintain stability and potency throughout its shelf life.

The medication is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a full glass of water and follow any specific instructions regarding timing relative to meals.

Serious adverse events include severe hypotension, acute kidney injury, hyperkalemia (especially when combined with potassium‑sparing agents), and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience symptoms like faintness, swelling of the face or throat, or sudden loss of kidney function.

The drug is contraindicated in patients with known hypersensitivity to irbesartan, hydrochlorothiazide, or any component of the formulation, as well as in individuals with severe renal impairment, anuria, or those taking aliskiren in combination with diabetes. Clinicians must evaluate each patient’s medical history before prescribing.