Product image of Irbesartan/Hydrochlorothiazide Axcount (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Irbesartan/Hydrochlorothiazide Axcount

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Irbesartan/Hydrochlorothiazide Axcount (Hydrochlorothiazide, Irbesartan)

Irbesartan/Hydrochlorothiazide, the active ingredient in Irbesartan/Hydrochlorothiazide Axcount, is an angiotensin II receptor blocker; thiazide diuretic presented as a tablet for oral use. It treats hypertension in adult patients.
GNH India supplies Irbesartan/Hydrochlorothiazide Axcount as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Axcount Generika Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Irbesartan/Hydrochlorothiazide is used to manage high blood pressure within the antihypertensive drug class.

  • Essential hypertension: lowers systolic and diastolic blood pressure to reduce cardiovascular risk.
  • Secondary hypertension: provides blood‑pressure control when hypertension is caused by another condition.
  • Hypertension in patients with diabetes: helps achieve target blood pressure while offering renal protective benefits.

How It Works

  • Irbesartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, increasing urinary excretion of water and electrolytes, which reduces plasma volume and peripheral resistance, together lowering arterial pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue or weakness
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)
  • Mild gastrointestinal upset

Serious or Rare Side Effects

  • Severe dehydration or electrolyte imbalance
  • Acute kidney injury
  • Hyperkalemia
  • Angioedema (swelling of face, lips, tongue)
  • Severe hypotension
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Blood pressure monitoring: ensure adequate control and avoid excessive drops.
  • Renal function assessment: check serum creatinine and eGFR regularly.
  • Electrolyte surveillance: monitor potassium and sodium levels, especially with concomitant drugs.
  • Pregnancy: contraindicated in pregnancy (Category D) due to fetal risk.
  • Elderly patients: start at lower dose and monitor for orthostatic hypotension.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan/Hydrochlorothiazide may interact with several medicines.

Major Interactions (Avoid)

  • Aliskiren: combined use can cause renal impairment and hyperkalemia.
  • Potassium‑sparing diuretics or supplements: risk of dangerous hyperkalemia.
  • Lithium: thiazide component can increase lithium levels and toxicity.
  • ACE inhibitors: additive effect on potassium and renal function.
  • NSAIDs: may blunt antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • CYP2C9 inhibitors (e.g., fluconazole): may increase irbesartan plasma concentrations.
  • Other antihypertensives: additive blood‑pressure lowering effect, monitor for hypotension.
  • Antidiabetic agents: diuretic‑induced changes in glucose may require dose adjustment.

Frequently Asked Questions

Irbesartan/Hydrochlorothiazide Axcount is an oral combination tablet used to treat hypertension. It combines an angiotensin II receptor blocker with a thiazide diuretic to lower blood pressure and reduce the risk of cardiovascular events in adult patients.

Irbesartan blocks AT1 receptors, preventing angiotensin II from causing vasoconstriction and aldosterone release. This leads to relaxation of blood vessels and reduced fluid retention, contributing to lower blood pressure.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s condition, response, and other medical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Irbesartan/Hydrochlorothiazide is classified as Pregnancy Category D, indicating evidence of fetal risk. It should not be used during pregnancy. Safety during breastfeeding has not been established, and a healthcare professional should be consulted before use.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with single‑agent therapies, the Irbesartan/Hydrochlorothiazide combination offers dual mechanisms—blocking the renin‑angiotensin system and promoting diuresis—often achieving better blood‑pressure control with a single tablet, which can improve adherence.

Store the tablets below 25 °C in their original packaging, protecting them from moisture and direct sunlight. Do not expose the product to excessive heat or humidity to maintain potency.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew it.

Serious risks include severe dehydration, electrolyte imbalance (especially low potassium), acute kidney injury, hyperkalemia, and rare cases of angioedema. Patients should report sudden swelling, severe dizziness, or marked changes in urine output to a healthcare professional promptly.

The combination should be avoided in patients with known hypersensitivity to irbesartan, hydrochlorothiazide, or any component of the formulation, in those with severe renal impairment, and in pregnant women. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Hydrochlorothiazide, Irbesartan

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT