Product image of Irbesartan/Hydrocholorthiazide Teva (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Irbesartan/Hydrocholorthiazide Teva

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Irbesartan/Hydrocholorthiazide Teva (Hydrochlorothiazide, Irbesartan)

Irbesartan, the active ingredient in Irbesartan/Hydrochlorothiazide Teva, is an angiotensin II receptor blocker presented as a combined tablet for oral use. It treats hypertension in adults, often together with hydrochlorothiazide.

GNH India supplies Irbesartan/Hydrochlorothiazide Teva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Irbesartan/Hydrochlorothiazide is used in the management of cardiovascular conditions, primarily hypertension.
  • Hypertension: lowers systolic and diastolic blood pressure, helping to control essential high blood pressure.

How It Works

  • Irbesartan selectively blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release, which reduces peripheral resistance. Hydrochlorothiazide acts on the distal convoluted tubule to inhibit Na⁺/Cl⁻ reabsorption, promoting natriuresis and diuresis, which further lowers blood volume and pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue or weakness
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)
  • Mild gastrointestinal upset

Serious or Rare Side Effects

  • Severe dehydration or electrolyte imbalance
  • Acute kidney injury or worsening renal function
  • Hyperkalemia or severe hyponatremia
  • Angioedema or severe allergic reaction
  • Significant hypotension
  • Pancreatitis (rare)

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Blood pressure monitoring: ensure adequate control and avoid excessive lowering.
  • Renal function assessment: check serum creatinine and eGFR, especially in patients with pre‑existing kidney disease.
  • Electrolyte surveillance: monitor potassium and sodium levels regularly.
  • Diabetes mellitus: watch for changes in blood glucose as diuretics may affect glycemic control.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit evaluation.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Irbesartan/Hydrochlorothiazide may interact with several medicines.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.
  • Lithium: increased lithium levels leading to toxicity.
  • ACE inhibitors or other ARBs: additive effect on blood pressure and renal function.
  • NSAIDs: may reduce antihypertensive efficacy and impair renal function.

Moderate Interactions (Monitor Closely)

  • Other antihypertensives: may cause excessive hypotension.
  • Antidiabetic agents: diuretic‑induced changes in glucose may require dose adjustment.
  • Corticosteroids: can increase sodium retention counteracting diuretic effect.
  • Antimicrobials such as trimethoprim‑sulfamethoxazole: may raise potassium levels.

Frequently Asked Questions

Irbesartan/Hydrochlorothiazide is prescribed to lower high blood pressure (hypertension) in adults. The combination works by relaxing blood vessels and increasing the excretion of excess fluid, helping to achieve better blood‑pressure control.

Irbesartan blocks angiotensin II type 1 (AT1) receptors, preventing the hormone from causing blood‑vessel constriction and aldosterone release. This leads to vasodilation and reduced sodium‑water retention, lowering blood pressure.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and other individual factors. Patients should follow the prescriber’s instructions exactly.

Safety in pregnancy and lactation has not been fully established. The medication should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request this product, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent therapies, the Irbesartan/Hydrochlorothiazide combo offers dual mechanisms—vascular relaxation and diuresis—in a single tablet, which can improve adherence and provide more consistent blood‑pressure reduction than using either agent alone.

Store the tablets at room temperature, below 25 °C, in the original packaging. Keep them away from moisture and direct sunlight to maintain stability and potency.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.

Serious risks include severe dehydration, electrolyte imbalances (especially low potassium), acute kidney injury, marked hypotension, and rare cases of angioedema. Patients should report symptoms such as faintness, rapid weight loss, swelling of the face or throat, or decreased urine output promptly.

The combination should be avoided in patients with known hypersensitivity to either component, severe renal impairment, anuria, or in those who are pregnant unless the benefits outweigh the risks. Clinicians should also exercise caution in patients with electrolyte disorders or severe liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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